Abstract: A capsule configured for collecting samples in the intestine, comprising a body delimiting at least one compartment for receiving samples and comprising at least one opening for samples intake, and a mobile mechanism for opening and/or closing the opening controlled by the dissolution of a material which is dissolvable in the intestine.

Abstract: Technology is described for improvement of a Boolean Network. The method can include applying a plurality of transformation scripts to a Boolean Network to form a plurality of levels of a transformation tree with nodes representing transformation metrics for the transformation scripts applied to the Boolean Network. The nodes in individual levels of the transformation tree can be prioritized based in part on a cost function that uses the transformation metrics to identify an improved node as compared to less improved nodes in each of the plurality of levels of the transformation tree. Another operation may be identifying a transformation script using improved nodes of the transformation tree.

Abstract: The present invention relates to novel thiazolo[5,4-f]quinazoline compounds and methods that are useful in the amelioration, treatment or control of Down's syndrome or early Alzheimer's disease or in the amelioration, treatment or control of cancers, especially solid tumors. More specifically, the invention relates to DYRK1A and/or DYRK1B inhibitors and to methods for preparing such compounds.

Abstract: The present invention relates to novel thiazolo[5,4-f]quinazoline compounds and methods that are useful in the amelioration, treatment or control of Down's syndrome or early Alzheimer's disease or in the amelioration, treatment or control of cancers, especially solid tumors. More specifically, the invention relates to DYRK1A and/or DYRK1B inhibitors and to methods for preparing such compounds.