Patents by Inventor Thierry Brossette

Thierry Brossette has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives
    Patent number: 6998494
    Abstract: The present invention concerns processes for the preparation of each of the 4 diastereomers of formula (I) in stereochemically pure form from either of two enantiomerically pure precursors. The tetracyclic ringsystem having trans-fused five and seven membered rings is formed in an acid-catalysed cyclization reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates, the methanamine end-products, the methanamine end-products for use as a medicine, in particular as CNS active medicines.
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: February 14, 2006
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Yolande Lydia Lang, Bart Petrus Anna Maria Jozef Medaer, Georges Joseph Cornelius Hoornaert, Thierry Brossette, Frans Josef Cornelius Compernolle, Michel Joseph Maurice André Guillaume, Hua Mao, Tomasz Kozlecki
  • Preparation of trans-fused 3,3a,8,12b-tetrahydro-2H-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives
    Publication number: 20050228043
    Abstract: The present invention concerns processes for the preparation of each of the 4 diastereomers of formula (I) in stereochemically pure form from either of two enantiomerically pure precursors. The tetracyclic ringsystem having trans-fused five and seven membered rings is formed in an acid-catalysed cyclization reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates, the methanamine end-products, the methanamine end-products for use as a medicine, in particular as CNS active medicines.
    Type: Application
    Filed: May 31, 2005
    Publication date: October 13, 2005
    Inventors: Yolande Lang, Bart Petrus Anna Medaer, Georges Hoornaert, Thierry Brossette, Frans Compernolle, Michel Joseph Guillaume, Hua Mao, Tomasz Kozlecki
  • Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives
    Publication number: 20050014820
    Abstract: The present invention concerns processes for the preparation of each of the 4 diastereomers of formula (I) in stereochemically pure form from either of two enantiomerically pure precursors. The tetracyclic ringsystem having trans-fused five and seven membered rings is formed in an acid-catalysed cyclization reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates, the methanamine end-products, the methanamine end-products for use as a medicine, in particular as CNS active medicines.
    Type: Application
    Filed: December 2, 2002
    Publication date: January 20, 2005
    Inventors: Yolande Lang, Bart Petrus Medaer, George Hoornaert, Thierry Brossette, Frans Compernolle, Michel Joseph Guillaume, Hua Mao, Tomasz Kozlecki