Abstract: Novel bispecific heterodimeric immunoglobulins that target both a component of the human CD47 antigen and human CD38 antigen are provided and in particular those comprising an anti-CD38 heavy chain variable region and a light chain variable region and an anti-CD47 heavy chain variable region and a light chain variable region. The present invention also relates to the use of this novel class of bispecific heterodimeric immunoglobulins to treat autoimmune and proliferative diseases and in particular cancers such as hematologic malignancies and solid tumors.

Abstract: The present invention relates to novel trispecific heterodimeric immunoglobulins. More specifically the present invention relates to trispecific heterodimeric immunoglobulins that target human CD3 antigen, human BCMA and human CD38 antigen. The present invention also relates to this novel class of trispecific heterodimeric immunoglobulins for use in the treatment of proliferative diseases and in particular cancers such as hematological cancer. The present invention relates to novel trispecific antibody for use in treating multiple myeloma.

Abstract: An optical film made from a light-permeable material includes a surface and an optical microstructure having a plurality of elevations. The elevations of the microstructure protrude from a reference plane, which is parallel to the surface. The elevations of the microstructure each have a flank section which adjoins the reference plane and forms a uniform angle with the reference plane. The uniform angle is in a range from about 33° to about 42° or in a range from about 35° to about 40°. The optical film according to the invention makes it possible to provide a light fixture with relatively strong glare suppression and at the same time to produce a preferred light distribution curve (LDC). In addition, it can be relatively flexibly moulded and cost-effectively produced.

Abstract: An optical layer made from a light-permeable material includes a surface and an optical microstructure having a plurality of elevations. The elevations of the microstructure protrude from a reference plane, which is parallel to the surface. The elevations of the microstructure each have a flank section which adjoins the reference plane and forms a uniform angle with the reference plane. The uniform angle is in a range from about 10° to about 26° or in a range from about 13° to about 23° or in a range from about 15° to about 20°. The optical layer according to the invention makes it possible for a light fixture to achieve a high light output rate (LOR) at the same time to produce a preferred light distribution curve (LDC).

Abstract: An optical layer made from a light-permeable material includes a surface and an optical microstructure having a plurality of elevations. The elevations of the microstructure protrude from a reference plane, which is parallel to the surface. The elevations of the microstructure each have a flank section which adjoins the reference plane and forms a uniform angle with the reference plane. The uniform angle is in a range from about 10° to about 26° or in a range from about 13° to about 23° or in a range from about 15° to about 20°. The optical layer according to the invention makes it possible for a light fixture to achieve a high light output rate (LOR) at the same time to produce a preferred light distribution curve (LDC).

Abstract: An optical film made from a light-permeable material includes a surface and an optical microstructure having a plurality of elevations. The elevations of the microstructure protrude from a reference plane, which is parallel to the surface. The elevations of the microstructure each have a flank section which adjoins the reference plane and forms a uniform angle with the reference plane. The uniform angle is in a range from about 33° to about 42° or in a range from about 35° to about 40°. The optical film according to the invention makes it possible to provide a light fixture with relatively strong glare suppression and at the same time to produce a preferred light distribution curve (LDC). In addition, it can be relatively flexibly moulded and cost-effectively produced.

Abstract: A process for obtaining aminopolyamide-epichlorohydrin resins with a 1,3-dichloro-2-propanol content which is undetectable by ordinary means of vapor-phase chromatography. The process consists of passing the products resulting from the successive condensation of aminopolyamides and epichlorohydrin through two columns of activated carbon. In this way, aqueous resins are obtained which are free of toxic products, and which are particularly valuable as wet strength additives in the manufacture of papers for medical, cosmetic or food contact uses.

Abstract: The present invention relates to a pressure-sensitive hot-melt adhesive composition characterized in that it includes a) at least one ethylene-alkyl acrylate copolymer, b) a tackifying resin and c) optionally a diluent and/or a stabilizer and/or a wax. Such a composition may be employed advantageously in the field of hygiene, especially for the adhesive bonding of disposable nappies and of catamenial liners.

Abstract: The invention relates to novolac resins obtained by condensation (A) of an aromatic compound containing at least two hydroxyl groups and (B) of an unconjugated diene in an (A)/(B) molar ratio of between 0.7 and 1.75 in the presence of an acidic catalyst, which are characterized in that the content of free aromatic compound is lower than 5% by weight. Also disclosed are a process for the preparation of the resins, and rubber-based compositions including from 0.5 to 20 parts by weight of the above mentioned novolac resins per 100 parts by weight of rubber. The invention also relates to the use of the resins or rubber-based compositions in the field of vulcanization, especially of tires and of conveyor belts.

Abstract: The present invention relates to a pressure-sensitive hot-melt adhesive composition characterized in that it includes a) at least one ethylene-vinyl acetate, ethylene-methyl acrylate or ethylene-butyl acrylate copolymer b) a solid tackifying resin c) a liquid tackifying resin d) an antioxidant e) and optionally a diluent. The invention also relates to the use of the pressure-sensitive hot-melt adhesive composition for the preparation of labels and adhesive tapes and more particularly of the tapes intended to come into contact with the skin.

Abstract: The invention relates to hot-melt adhesives characterized in that they include: a) 30 to 90% by weight (A) of at least one essentially amorphous poly-alpha-olefin and (B) of at least one ethylene/alkyl (meth)acrylate copolymer, the weight ratio (B)/(A)+(B) being between 0.05 and 0.55; b) 10 to 70% by weight of a tackifying resin; c) 0.1 to 3 parts by weight of an antioxidant for 100 parts by weight of the compounds under a) and b). It also relates to the use of these adhesives in the wood, bookbinding and packaging industries.

Abstract: New formaldehyde-phenol resins of the novolak type comprising aliphatic aldehyde radicals with 6 or more carbon atoms and with the molar ratio between these heavy aldehyde radicals and the phenolic structures being between 0.9 and 1.2. They are obtained by the condensation of phenols with aldehyde compounds containing at least 543% heavy aldehydes in the presence of acid catalysts in a virtually anhydrous medium. Application to the reinforcement of vulcanized rubbers.