Patents by Inventor Thierry Durand

Thierry Durand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo?2.2.1!heptane compound and the preparation of 2-azabicyclo?2.2.1!heptane compounds
    Patent number: 5684159
    Abstract: A method according to the invention is directed to the preparation of a 2-azadihydroxybicyclo?2.2.1!heptane compound of formula ##STR1## wherein * represents an R chirality, *' represents an S chirality, R is hydrogen or, respectively, a group of formula ##STR2## wherein R.sub.1 is alkyl and Ar is optionally substituted aryl, comprising bishydroxylating a bicyclo?2.2.1!heptene compound of formula ##STR3## wherein *, *' and R are as previously defined, in the presence of about 0.1 mol to about 5 mol % of a metal osmate compound or about 0.06 mol % to about 0.07 mol % osmium tetroxide, and an oxidizing agent capable of regenerating osmium tetroxide.The invention is also directed to the treatment of the (1R) diastereomer of the 2-azadihydroxybicyclo?2.2.1!heptane compound (I) wherein R is a group of formula II with L-tartaric acid, and the L-tartaric acid salt product thereof. Furthermore, the invention is directed to using the (1R) diastereomer of the 2-azadihydroxybicyclo?2.2.
    Type: Grant
    Filed: October 16, 1996
    Date of Patent: November 4, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Michael O'Brien, Patrick Leon, Denis Largeau, Matthew Powers, Thierry Durand