Patents by Inventor Thierry F. Calandra

Thierry F. Calandra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITION OF MIGRATION INHIBITORY FACTOR IN THE TREATMENT OF DISEASES INVOLVING CYTOKINE-MEDIATED TOXICITY
    Publication number: 20120149044
    Abstract: The present invention relates to diagnostic methods for determining migration inhibitory factor (MIF) mRNA content in a sample, wherein MIF is human MIF polypeptide having a molecular weight of approximately 12.5 kDa and kits for detecting MIF.
    Type: Application
    Filed: February 24, 2012
    Publication date: June 14, 2012
    Applicants: Baxter Healthcare S.A., Baxter International Inc.
    Inventors: Richard J. Bucala, Robert A. Mitchell, Jurgen Bernhagen, Thierry F. Calandra, Anthony Cerami
  • INHIBITION OF MIGRATION INHIBITORY FACTOR IN THE TREATMENT OF DISEASES INVOLVING CYTOKINE-MEDIATED TOXICITY
    Publication number: 20120028281
    Abstract: The present invention relates to diagnostic methods for determining migration inhibitory factor (MIF) mRNA content in a sample, wherein MIF is human MIF polypeptide having a molecular weight of approximately 12.5 kDa and kits for detecting MIF.
    Type: Application
    Filed: July 20, 2011
    Publication date: February 2, 2012
    Inventors: Richard J. Bucala, Robert A. Mitchell, Jurgen Bernhagen, Thierry F. Calandra, Anthony Cerami
  • Method for determining MIF content
    Publication number: 20100184091
    Abstract: The present invention relates to diagnostic methods for determining migration inhibitory factor (MIF) mRNA content in a sample, wherein MIF is human MIF polypeptide having a molecular weight of approximately 12.5 kDa and kits for detecting MIF.
    Type: Application
    Filed: June 3, 2009
    Publication date: July 22, 2010
    Applicant: Cytokine PharmaSciences, Inc.
    Inventors: Richard J. Bucala, Robert A. Mitchell, Jurgen Bernhagen, Thierry F. Calandra, Anthony Cerami
  • Anti-MIF antibodies
    Patent number: 7517523
    Abstract: The present invention relates to compositions and methods for inhibiting the release and/or biological activity of migration inhibitory factor (MIF). In particular, the invention relates to the uses of such compositions and methods for the treatment of various conditions involving cytokine-mediated toxicity, which include, but are not limited to shock, inflammation, graft versus host disease, and/or autoimmune diseases.
    Type: Grant
    Filed: June 17, 2003
    Date of Patent: April 14, 2009
    Assignee: Cytokine PharmaSciences, Inc.
    Inventors: Richard Bucala, Robert A. Mitchell, Jurgen Bernhagen, Thierry F. Calandra, Anthony Cerami
  • Method for determining MIF content
    Patent number: 6998238
    Abstract: A diagnostic method for determining MIF protein content in a sample using a direct or an indirect detection technique and wherein MIF is a human MIF protein having a molecular weight of approximately 12.5 kDa.
    Type: Grant
    Filed: April 25, 2000
    Date of Patent: February 14, 2006
    Assignee: Cytokine PharmaSciences, Inc.
    Inventors: Richard J. Bucala, Robert A. Mitchell, Jurgen Bernhagen, Thierry F. Calandra, Anthony Cerami
  • Inhibition of migration inhibitory factor in the treatment of diseases involving cytokine-mediated toxicity
    Publication number: 20040053843
    Abstract: The present invention relates to compositions and methods for inhibiting the release and/or biological activity of migration inhibitory factor (MIF). In particular, the invention relates to the uses of such compositions and methods for the treatment of various conditions #involving cytokine-mediated toxicity, which include, but are not limited to shock, inflammation, graft versus host disease, and/or autoimmune diseases.
    Type: Application
    Filed: June 17, 2003
    Publication date: March 18, 2004
    Inventors: Richard J. Bucala, Robert A. Mitchell, Jurgen Bernhagen, Thierry F. Calandra, Anthony Cerami
  • Composition containing anti-MIF antibody
    Patent number: 6645493
    Abstract: The present invention relates to compositions and methods for inhibiting the release and/or biological activity of migration inhibitory factor (MIF). In particular, the invention relates to the uses of such compositions and methods for the treatment of various conditions involving cytokine-mediated toxicity, which include, but are not limited to shock, inflammation, graft versus host disease, and/or autoimmune diseases.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 11, 2003
    Assignee: The Picower Institute for Medical Research
    Inventors: Richard J. Bucala, Robert A. Mitchell, Jurgen Bernhagen, Thierry F. Calandra, Anthony Cerami
  • Inhibition of migration inhibitory factor in the treatment of diseases involving cytokine-mediated toxicity
    Publication number: 20030099653
    Abstract: The present invention relates to compositions and methods for inhibiting the release and/or biological activity of migration inhibitory factor (MIF). In particular, the invention relates to the uses of such compositions and methods for the treatment of various conditions #involving cytokine-mediated toxicity, which include, but are not limited to shock, inflammation, graft versus host disease, and/or autoimmune diseases.
    Type: Application
    Filed: April 25, 2000
    Publication date: May 29, 2003
    Inventors: Richard J. Bucala, Robert A. Mitchell, Jurgen Bernhagen, Thierry F. Calandra, Anthony Cerami
  • Diagnostic assays for MIF
    Patent number: 6080407
    Abstract: The present invention relates to compositions and methods for inhibiting the release and/or biological activity of migration inhibitory factor (MIF). In particular, the invention relates to the uses of such compositions and methods for the treatment of various conditions involving cytokine-mediated toxicity, which include, but are not limited to shock, inflammation, graft versus host disease, and/or autoimmune diseases.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 27, 2000
    Assignee: The Picower Institute for Medical Research
    Inventors: Richard J. Bucala, Robert A. Mitchell, Jurgen Bernhagen, Thierry F. Calandra, Anthony Cerami
  • Combination method for treating diseases caused by cytokine-mediated toxicity
    Patent number: 6030615
    Abstract: There is disclosed a method for treating an individual having a disease caused by cytokine-mediated toxicity comprising administering to the individual an effective amount of (a) an antibody that binds to an MIF polypeptide, wherein the MIF polypeptide has a molecular weight of about 12.5 kDa in combination with (b) anti-TNF.alpha., anti-IL1, anti-IFN-.gamma., IL-1RA, a steroid, a glucocorticoid, or IL-10.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 29, 2000
    Assignee: The Picower Institute for Medical Research
    Inventors: Richard J. Bucala, Robert A. Mitchell, Jurgen Bernhagen, Thierry F. Calandra, Anthony Cerami