Patents by Inventor Thierry Guyon

Thierry Guyon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified erythropoietin polypeptides and uses thereof
    Publication number: 20090238789
    Abstract: Modified erythropoietin (EPO) polypeptides and other modified therapeutic polypeptides are provided. The EPO polypeptides and other therapeutic polypeptides are modified to exhibit physical properties and activities that differ from the unmodified EPO polypeptides and other unmodified therapeutic polypeptides, respectively. Nucleic acid molecules encoding these polypeptides also are provided. Also provided are methods of treatment and diagnosis using the polypeptides.
    Type: Application
    Filed: November 28, 2007
    Publication date: September 24, 2009
    Inventors: Thierry Guyon, Gilles Borrelly, Xavier Gallet, Lila Drittanti, Manuel Vega
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20090131318
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: June 6, 2008
    Publication date: May 21, 2009
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20090123974
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: April 9, 2008
    Publication date: May 14, 2009
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20090053147
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: April 9, 2008
    Publication date: February 26, 2009
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20080274081
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: February 13, 2007
    Publication date: November 6, 2008
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20080194477
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: February 7, 2007
    Publication date: August 14, 2008
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20080159977
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: July 5, 2007
    Publication date: July 3, 2008
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Novel Fluorene Derivatives, Composition Containing Said Derivatives and the Use Thereof
    Publication number: 20080153837
    Abstract: This invention relates to derivatives of 4-(benzimidazol-2-yl)fluorene and 4-(azabenzimidazol-2-yl)fluorene, to pharmaceutical compositions comprising such derivatives, and to methods of treatment of disorders related to Hsp90 protein activity, comprising administering such derivatives.
    Type: Application
    Filed: November 14, 2007
    Publication date: June 26, 2008
    Applicant: AVENTIS PHARMA S.A.
    Inventors: Patrick MAILLIET, Luc BERTIN, Fabienne THOMPSON, Jean-Marie RUXER, Fabienne PILORGE, Didier BENARD, Herve MINOUX, Chantal CARREZ, Helene GOULAOUIC, Thierry GUYON
  • Modified coagulation factor IX polypeptides and use thereof for treatment
    Publication number: 20080102115
    Abstract: Provided are modified factor IX (FIX) polypeptides and methods of generating modified FIX polypeptides. Also provided are pharmaceutical compositions, including compositions formulation for oral administration, that contain the modified FIX polypeptides, and methods of treatment using modified FIX polypeptides.
    Type: Application
    Filed: June 15, 2007
    Publication date: May 1, 2008
    Inventors: Jorge Oyhenart, Xavier Gallet, Gilles Borrelly, Thierry Guyon, Manuel Vega, Lila Drittanti
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20080075672
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: February 6, 2007
    Publication date: March 27, 2008
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Use of polypeptides obtained through systematic mutations of single amino acids of human and non-human Box-A of HMGB1 to prevent and/or antagonize pathologies induced by HMGB1
    Publication number: 20080038309
    Abstract: The present invention relates to polypeptide variants of the HMGB-1 high affinity binding domain Box-A (HMGB1 Box-A) or to a biologically active fragment of HMGB1 Box-A, which are obtained through systematic mutations of single amino acids of the wild-type HMGB1 Box-A protein and which show an increased resistance to proteases and which are therefore characterized by more favourable pharmacokinetic and pharmacodynamic profiles. Moreover, the present invention concerns the use of said polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1 and associated with RAGE.
    Type: Application
    Filed: March 5, 2007
    Publication date: February 14, 2008
    Applicant: CREABILIS THERAPEUTICS S.p.A.
    Inventors: Silvano Fumero, Luisa Bertarione Rava Rossa, Domenico Barone, Lila Drittanti, Thierry Guyon, Gilles Borrelly, Barbara Canepa, Chiara Lorenzetto
  • Modified interferon-beta (IFN-beta) polypeptides
    Publication number: 20080038224
    Abstract: Provided are modified interferon-beta polypeptides and nucleic acid molecules encoding modified interferon-beta polypeptides and formulations containing the polypeptides and/or nucleic acid molecules. The modified polypeptides exhibit increased protein stability, including increased resistance to proteases. Also provided are methods of treatment by administering modified interferon-beta polypeptides.
    Type: Application
    Filed: March 27, 2007
    Publication date: February 14, 2008
    Inventors: Thierry Guyon, Gilles Borrelly, Lila Drittanti, Manuel Vega
  • Modified growth hormones
    Publication number: 20080026993
    Abstract: Provided are modified growth hormone polypeptides, nucleic acid molecules encoding modified growth hormone polypeptides and methods of generating modified growth hormone polypeptides. Also provided are methods of treatment using modified growth hormone polypeptides.
    Type: Application
    Filed: June 26, 2006
    Publication date: January 31, 2008
    Inventors: Thierry Guyon, Gilles Borrelly, Lila Drittanti, Manuel Vega
  • Modified interferon-beta (IFN-beta) polypeptides
    Publication number: 20080003202
    Abstract: Provided are modified interferon-beta polypeptides and nucleic acid molecules encoding modified interferon-beta polypeptides and formulations containing the polypeptides and/or nucleic acid molecules. The modified polypeptides exhibit increased protein stability, including increased resistance to proteases. Also provided are methods of treatment by administering modified interferon-beta polypeptides.
    Type: Application
    Filed: March 27, 2007
    Publication date: January 3, 2008
    Inventors: Thierry Guyon, Gilles Borrelly, Lila Drittanti, Manuel Vega
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20070254838
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: January 22, 2007
    Publication date: November 1, 2007
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Modified growth hormones
    Publication number: 20070249532
    Abstract: Provided are modified growth hormone polypeptides, nucleic acid molecules encoding modified growth hormone polypeptides and methods of generating modified growth hormone polypeptides. Also provided are methods of treatment using modified growth hormone polypeptides.
    Type: Application
    Filed: November 3, 2005
    Publication date: October 25, 2007
    Inventors: Thierry Guyon, Gilles Borrelly, Lila Drittanti, Manuel Vega
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20070224665
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: February 14, 2007
    Publication date: September 27, 2007
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
    Publication number: 20070172459
    Abstract: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines.
    Type: Application
    Filed: February 13, 2007
    Publication date: July 26, 2007
    Inventors: Rene Gantier, Manuel Vega, Lila Drittanti, Thierry Guyon
  • Modified interferon-gamma polypeptides and methods for using modified interferon-gamma polypeptides
    Publication number: 20060251619
    Abstract: Provided are modified interferon-gamma (IFN-?) polypeptides and methods of generating modified interferon-gamma polypeptides. Also provided are methods of treatment using modified interferon-gamma polypeptides.
    Type: Application
    Filed: May 4, 2006
    Publication date: November 9, 2006
    Inventors: Gilles Borrelly, Thierry Guyon, Lila Drittanti
  • Modified growth hormones
    Publication number: 20060247170
    Abstract: Provided are modified growth hormone polypeptides, nucleic acid molecules encoding modified growth hormone polypeptides and methods of generating modified growth hormone polypeptides. Also provided are methods of treatment using modified growth hormone polypeptides.
    Type: Application
    Filed: June 26, 2006
    Publication date: November 2, 2006
    Inventors: Thierry Guyon, Gilles Borrelly, Lila Drittanti, Manuel Vega