Patents by Inventor Thierry Pedrazzini

Thierry Pedrazzini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnostic, prognostic and therapeutic uses of long noncoding RNAs for pathologies and toxicities inducing heart disorders
    Patent number: 11667974
    Abstract: The present invention provides methods for the diagnosing, monitoring and prognostication of primary and secondary cardiac disorders in a subject based on lncRNA expression. The invention also provides methods for predicting heart failure after myocardial infarction, and differenciation of Ischemic versus non-ischemic Heart Failure. The assessment/quantification of these lncRNAs may also be used as a marker for monitoring drug-induced cardiac toxicities and for the assessment of cardiac involvement during systemic diseases and others disorders/toxicities impacting cardiac function. These lncRNAs are cardiac tissue enriched and may be involved in different cardiac pathophysiological events and represent a potential target for therapeutical approaches.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: June 6, 2023
    Assignees: FIRALIS SA, LUXEMBOURG INSTITUTE OF HEALTH, THE UNIVERSITY HOSPITAL OF LAUSANNE, THE CARDINAL STEFA WUSZYNSKI INSTITUTE OF CARDIOLOGY
    Inventors: Hueseyin Firat, Sabrina Danilin, Yvan Devaux, Lu Zhang, Przemyslaw Leszek, Eric Schordan, Samir Ounzain, Thierry Pedrazzini
  • Diagnostic, Prognostic And Therapeutic Uses Of Long Noncoding RNAs For Heart Disease And Regenerative Medicine
    Publication number: 20220136054
    Abstract: This invention generally relates to lncRNAs and methods for diagnosing cardiac pathologies in a subject. The invention also provides methods for treating a cardiac pathology in a subject comprising administering to said subject an effective amount of a modulator of one or more lncRNAs of the invention.
    Type: Application
    Filed: October 19, 2021
    Publication date: May 5, 2022
    Inventors: Samir OUNZAIN, Thierry PEDRAZZINI
  • Diagnostic, prognostic and therapeutic uses of long noncoding RNAS for heart disease and regenerative medicine
    Patent number: 11193171
    Abstract: This invention generally relates to lncRNAs and methods for diagnosing cardiac pathologies in a subject. The invention also provides methods for treating a cardiac pathology in a subject comprising administering to said subject an effective amount of a modulator of one or more lncRNAs of the invention.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: December 7, 2021
    Assignee: UNIVERSITÉ DE LAUSANNE
    Inventors: Samir Ounzain, Thierry Pedrazzini
  • DIAGNOSTIC, PROGNOSTIC AND THERAPEUTIC USES OF LONG NONCODING RNAs FOR PATHOLOGIES AND TOXICITIES INDUCING HEART DISORDERS
    Publication number: 20210189491
    Abstract: The present invention provides methods for the diagnosing, monitoring and prognostication of primary and secondary cardiac disorders in a subject based on lncRNA expression. The invention also provides methods for predicting heart failure after myocardial infarction, and differenciation of Ischemic versus non-ischemic Heart Failure. The assessment/quantification of these lncRNAs may also be used as a marker for monitoring drug-induced cardiac toxicities and for the assessment of cardiac involvement during systemic diseases and others disorders/toxicities impacting cardiac function. These lncRNAs are cardiac tissue enriched and may be involved in different cardiac pathophysiological events and represent a potential target for therapeutical approaches.
    Type: Application
    Filed: June 12, 2018
    Publication date: June 24, 2021
    Inventors: Hueseyin FIRAT, Sabrina DANILIN, Yvan DEVAUX, Lu ZHANG, Przemyslaw LESZEK, Eric SCHORDAN, Samir OUNZAIN, Thierry PEDRAZZINI
  • Methods And Compositions For Controlling Cardiac Fibrosis And Remodeling
    Publication number: 20200197432
    Abstract: The present invention provides methods and compositions for controlling cardiac fibrosis and heart remodeling in a subject via modulating the expression of one or more lncRNA associated with cardiac-specific super-enhancers (SEs).
    Type: Application
    Filed: June 19, 2018
    Publication date: June 25, 2020
    Inventors: Samir OUNZAIN, Thierry PEDRAZZINI
  • DIAGNOSTIC, PROGNOSTIC AND THERAPEUTIC USES OF LONG NONCODING RNAS FOR HEART DISEASE AND REGENERATIVE MEDICINE
    Publication number: 20160312283
    Abstract: This invention generally relates to lncRNAs and methods for diagnosing cardiac pathologies in a subject. The invention also provides methods for treating a cardiac pathology in a subject comprising administering to said subject an effective amount of a modulator of one or more lncRNAs of the invention.
    Type: Application
    Filed: December 19, 2014
    Publication date: October 27, 2016
    Inventors: Samir OUNZAIN, Thierry PEDRAZZINI
  • Transgenic mice with disrupted NPY Y1 receptor genes
    Patent number: 5817912
    Abstract: The present invention is directed to transgenic animals which have been engineered by homologous recombination to be deficient in the expression of the neuropeptide Y Y1 receptor. The invention encompasses the DNA constructs and engineered embryonic stem cells used to produce the animals, the transgenic animals themselves, and assays which utilize either the animals or tissues derived from the animals.
    Type: Grant
    Filed: January 16, 1997
    Date of Patent: October 6, 1998
    Assignee: B.M.R.A. Corporation B.V.
    Inventors: Thierry Pedrazzini, Hans R. Brunner