Patents by Inventor Thimmegowda N.R.

Thimmegowda N.R. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tubulin polymerization inhibitor and method for synthesizing same
    Patent number: 9643959
    Abstract: The present invention relates to (E)-ethyl 2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate as a novel tubulin polymerization inhibitor and a method for synthesizing the same. The compound of the present invention can inhibit mitosis and induce apoptosis and thus be used as an anticancer agent, by binding to tubulin to inhibit microtube polymerization. According to the synthesis method of the present invention, the reaction is simplified and the efficiency is 60% or higher, leading to a very high yield, thereby providing an effective synthesis method.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: May 9, 2017
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Bo Yeon Kim, Thimmegowda N.R., Sun Ok Kim, Nak Kyun Soung, Krisada Sakchaisri, InJa Ryoo, Chan-Mi Park, Jong Seog Ahn, Jae-Hyuk Jang
  • NOVEL TUBULIN POLYMERIZATION INHIBITOR AND METHOD FOR SYNTHESIZING SAME
    Publication number: 20160102078
    Abstract: The present invention relates to (E)-ethyl 2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate as a novel tubulin polymerization inhibitor and a method for synthesizing the same. The compound of the present invention can inhibit mitosis and induce apoptosis and thus be used as an anticancer agent, by binding to tubulin to inhibit microtube polymerization. According to the synthesis method of the present invention, the reaction is simplified and the efficiency is 60%, or higher, leading to a very high yield, thereby providing an effective synthesis method.
    Type: Application
    Filed: April 22, 2014
    Publication date: April 14, 2016
    Inventors: Bo Yeon KIM, Thimmegowda N.R., Sun Ok KIM, Nak Kyun SOUNG, Krisada SAKCHAISRI, InJa RYOO, Chan-Mi PARK, Jong Seog AHN, Jae-Hyuk JANG