Patents by Inventor Thiruganesh Ramasamy

Thiruganesh Ramasamy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Functionalized microbubble embodiments for ultrasound-mediated treatment and methods of making and using the same
    Patent number: 11793863
    Abstract: Disclosed herein are embodiments of a functionalized microbubble designed for treating and/or preventing vascular obstructions, including microvascular obstructions. The functionalized microbubble embodiments comprise a microbubble that can be activated upon exposure to ultrasound and further that has a lipid-based shell that is attached to an exteriorly-attached therapeutically active agent, such as a thrombolytic agent. Also disclosed herein are embodiments of a method for making and using the functionalized microbubble embodiments.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: October 24, 2023
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, UPMC
    Inventors: John J. Pacella, Xucai Chen, Francois Tchi Ho Yu, Thiruganesh Ramasamy, Stephen D'Auria
  • Nitro-Fatty Acid-Containing Microbubbles and Uses Therefor
    Publication number: 20230065014
    Abstract: Provided herein are microbubble compositions comprising nitro-fatty acids and/or esters thereof, such as amphiphilic esters or allyl esters thereof. Also provided are methods of reducing local inflammation at a site in a patient comprising delivering the microbubbles to a site of inflammation in the patient and applying ultrasound to the microbubbles. The methods may be used to treat fibrosis or cancer.
    Type: Application
    Filed: January 14, 2021
    Publication date: March 2, 2023
    Inventors: Gary Yu, Bruce A. Freeman, Flordeliza S. Villanueva, John J. Pacella, Marco Fazzari, Xucai Chen, Thiruganesh Ramasamy
  • FUNCTIONALIZED MICROBUBBLE EMBODIMENTS FOR ULTRASOUND-MEDIATED TREATMENT AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20200338172
    Abstract: Disclosed herein are embodiments of a functionalized microbubble designed for treating and/or preventing vascular obstructions, including microvascular obstructions. The functionalized microbubble embodiments comprise a microbubble that can be activated upon exposure to ultrasound and further that has a lipid-based shell that is attached to an exteriorly-attached therapeutically active agent, such as a thrombolytic agent. Also disclosed herein are embodiments of a method for making and using the functionalized microbubble embodiments.
    Type: Application
    Filed: April 24, 2020
    Publication date: October 29, 2020
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, UPMC
    Inventors: John J. Pacella, Xucai Chen, Francois Tchi Ho Yu, Thiruganesh Ramasamy, Stephen D'Auria