Patents by Inventor Thirumalai Rajan Srinivasan

Thirumalai Rajan Srinivasan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STABLE N-((1R,2R)-1-(2,3-DIHYDROBENZO[B][1,4]DIOXIN-6-YL)-1-HYDROXY-3-(PYRROLIDIN-1-YL)PROPAN-2-YL) OCTANAMIDE (2R,3R)-2,3-DIHYDROXYSUCCINATE PREMIX AND PROCESS FOR PREPARATION THEREOF
    Publication number: 20200306225
    Abstract: The present invention related to stable N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl) -1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl) octanamide (2R,3R)-2,3-dihydroxysuccinate premix of formula (Ia) and its process for preparation thereof.
    Type: Application
    Filed: October 26, 2018
    Publication date: October 1, 2020
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Venkat Redby GHOJALA, Rajeshwar Reddy SAGYAM, Venkat Reddy MALLEPALLY, Ravinder reddy KOPPERA, Adilakshmi SINGAVARAPU, Srinivasulu RANGINENI
  • SOLID STATE FORMS OF 5-CHLORO-6-[(2-IMINOPYRROLIDIN-1-YL)METHYL]PYRIMIDINE-2,4-(1H,3H)-DIONE HYDROCHLORIDE AND THEIR PROCESSES FOR THE PREPARATION THEREOF
    Publication number: 20200283413
    Abstract: The present invention relates to solid state forms of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride compound of formula-1a and their processes for the preparation thereof and an improved process for the preparation of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride. The present inventors also provides an amorphous polymorph of the combination drug consisting of 2?-deoxy-5-(trifluoromethyl) uridine and 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione monohydrochloride and its process for the preparation.
    Type: Application
    Filed: September 7, 2018
    Publication date: September 10, 2020
    Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Venkat Reddy GHOJALA, Rajeshwar Reddy SAGYAM, Srinivasulu RANGINENI, Rajashekar KOMMERA, Markandeya BEKKAM
  • Process for the preparation of Trisodium (4- {[1S,3R)-1-([1,1?-biphenyl]-4-ylmethyl)-4-ethoxy-3-methyl-4-oxobutyl]amino}-4-oxobutanoate)-(N-petanoyl-N-{[2?-(1H-tetrazol-1-1D-5-yl)[1,1?-biphenyl]-4-yl]methyl}- L-valinate) and its polymorphs thereof
    Patent number: 10703731
    Abstract: The present invention relates to a process for the preparation of Trisodium (4-{[(1S.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: July 7, 2020
    Assignee: MSN LABORATORIES PRIVATE LIMITED
    Inventors: Thirumalai Rajan Srinivasan, Eswaraiah Sajja, Rajeshwar Reddy Sagyam, Rajesham Boge, Chkradhar Nandigama, Srinivasa Rao Ambati
  • PROCESS FOR THE PREPARATION OF 5-(4-CYANOPHENOXY)-1,3-DIHYDRO-1-HYDROXY-[2,1]-BENZOXABOROLE AND POLYMORPHS THEREOF
    Publication number: 20200190120
    Abstract: The present invention relates to process for the preparation of 5-(4-cyano phenoxy)- 1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole represented by the following structural formula-1 and polymorphs thereof. The present invention also relates to salts of 5-(4-cyano phenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole and process for their preparation and their use in the preparation of pure compound of the formula-1.
    Type: Application
    Filed: May 23, 2018
    Publication date: June 18, 2020
    Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Venkat Reddy GHOJALA, Markandeya BEKKAM
  • SOLID STATE FORMS OF N-[2-[(I S)-1 -(3-ETHOXY-4-METHOXYPHENYL)-2-(METHYL SULFONYL)ETHYL]-2,3-DIHYDRO-1,3-DIOXO-L H-ISOINDOL-4-YL]ACETAMIDE AND PROCESS FOR PREPARATION THEREOF
    Publication number: 20200109114
    Abstract: The present invention, relates to solid state forms of N-[2-[(1 S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide represented by the following structural formula-1 and process for their preparation. The present invention also relates to an improved process for the preparation of N-[2-[(1 S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide compound of formula-1 and intermediates thereof.
    Type: Application
    Filed: December 7, 2019
    Publication date: April 9, 2020
    Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan Srinivasan, Eswaraiah Sajja, Venkat Reddy Ghojala, Pradeep Rebelli
  • Process for the preparation of N-[4-[(3-chloro-4-fluoro phenyl) amino]-7-[[(3s-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethyl amino)-(2E)-2-butenamide (2Z)-2-butenedioate (1:2) and its polymorphs thereof
    Patent number: 10550107
    Abstract: The present invention relates to an improved process for the preparation of N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethyl amino)-(2E)-2-butenamide (2Z)-2-butenedioate (1:2) represented by the following structural formula:
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: February 4, 2020
    Assignee: MSN LABORATORIES PRIVATE LIMITED
    Inventors: Thirumalai Rajan Srinivasan, Eswaraiah Sajja, Venkata Panakala Rao Gogulapati, Rajesham Boge
  • Solid state forms of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide and process for preparation thereof
    Patent number: 10544097
    Abstract: The present invention, relates to solid state forms of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide represented by the following structural formula-1 and process for their preparation. The present invention also relates to an improved process for the preparation of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide compound of formula-1 and intermediates thereof.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: January 28, 2020
    Assignee: MSN LABORATORIES PRIVATE LIMITED
    Inventors: Thirumalai Rajan Srinivasan, Eswaraiah Sajja, Venkat Reddy Ghojala, Pradeep Rebelli
  • A PROCESS FOR THE PREPARATION OF D-GLUCITOL, 1,5-ANHYDRO-1-C-[4-CHLORO-3-[[4- [[(3S)-TETRAHYDRO-3-FURANYL]OXY]PHENYL]METHYL]PHENYL]-, ( 1 S)
    Publication number: 20200017483
    Abstract: The present invention relates to a process for the preparation of D-glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl)oxy)phenyl] methyl]phenyl]-, (IS) formula-1.
    Type: Application
    Filed: March 12, 2018
    Publication date: January 16, 2020
    Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Venkata Panakala Rao GOGULAPATI, Rajeshwar Reddy SAGYAM, Mohammad Rafee SHAIK, Srinivasuslu RANGINENI
  • PROCESSES FOR THE PREPARATION OF 7-{4-[4-(1-BENZOTHIOPHEN-4-YL) PIPERAZIN-1-YL]BUTOXY}QUINOLIN-2(1H)-ONE
    Publication number: 20190359606
    Abstract: The Present Invention of relates to process for the preparation of 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one represented by the following structural formula-1.
    Type: Application
    Filed: November 7, 2017
    Publication date: November 28, 2019
    Applicant: MSN LABORATORIES PRIVATE LIMITED
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Venkat Reddy GHOJALA, Rajashekar KOMMERA
  • PROCESS FOR THE PREPARATION OF TRISODIUM (4-{[1S,3R)-1-([1,1'-BIPHENYL]-4-YLMETHYL)-4-ETHOXY-3-METHYL-4-OXOBUTYL]AMINO}-4-OXOBUTANOATE)-(N-PETANOYL-N-{[2'-(1H-TETRAZOL-1-1D-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL}- L-VALINATE) AND ITS POLYMORPHS THEREOF
    Publication number: 20190077775
    Abstract: The present invention relates to a process for the preparation of Trisodium (4-{[(1S.
    Type: Application
    Filed: March 6, 2017
    Publication date: March 14, 2019
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Rajeshwar Reddy SAGYAM, Rajesham BOGE, Chkradhar NANDIGAMA, Srinivasa Rao AMBATI
  • PROCESS FOR THE PREPARATION OF D-GLUCITOL, 1,5-ANHYDRO-1-C-[4-CHLORO-3-[[4-[[(3S)-TETRAHYDRO-3-FURANYL] OXY]PHENYL] METHYL] PHENYL]-, (1S) AND ITS CRYSTALLINE FORMS THEREOF
    Publication number: 20190040094
    Abstract: The present invention relates to process for the preparation of D-glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl] methyl]phenyl]-, (1S) formula-1 and its crystalline forms thereof.
    Type: Application
    Filed: January 27, 2017
    Publication date: February 7, 2019
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaralah SAJJA, Venkata Panakala Rao GOGULAPATI, Rajeshwar Reddy SAGYAM, Rajesham BODGE, Mohammad Rafee SHAIK
  • PROCESS FOR THE PREPARATION OF N-[4-[(3-CHLORO-4-FLUORO PHENYL) AMINO]-7-[[(3s-TETRAHYDRO-3-FURANYL]OXY]-6-QUINAZOLINYL]-4-(DIMETHYL AMINO)-(2E)-2-BUTENAMIDE (2Z)-2-BUTENEDIOATE (1 :2) AND ITS POLYMORPHS THEREOF
    Publication number: 20180297989
    Abstract: The present invention relates to an improved process for the preparation of N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethyl amino)-(2E)-2-butenamide (2Z)-2-butenedioate (1:2) represented by the following structural formula:
    Type: Application
    Filed: May 11, 2016
    Publication date: October 18, 2018
    Applicant: MSN LABORATORIES PRIVATE LIMITED
    Inventor: Thirumalai Rajan SRINIVASAN
  • Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof
    Patent number: 7790886
    Abstract: The present invention is related to crystalline forms of ziprasidone and its hydrochloride salt and an amorphous form of ziprasidone hydrochloride and the process for the preparation thereof. The crystalline forms and amorphous form of the invention are suitable for pharmaceutical purposes in the treatment of psychosis. The processes of the invention are simple, non-hazardous and commercially suitable.
    Type: Grant
    Filed: January 5, 2009
    Date of Patent: September 7, 2010
    Assignees: Dr. Reddy's Laboratories, Inc., Dr. Reddy's Laboratories Limited
    Inventors: Manne Satyanarayana Reddy, Thirumalai Rajan Srinivasan, Venka Bhaskara Rao Uppala, Mummadi Venkatesh, Akundi Surya Prabhakar
  • POLYMORPHIC FORMS OF ZIPRASIDONEAND ITS HYDROCHLORIDE SALT AND PROCESS FOR PREPARATION THEREOF
    Publication number: 20090137605
    Abstract: The present invention is related to crystalline forms of ziprasidone and its hydrochloride salt and an amorphous form of ziprasidone hydrochloride and the process for the preparation thereof. The crystalline forms and amorphous form of the invention are suitable for pharmaceutical purposes in the treatment of psychosis. The processes of the invention are simple, non-hazardous and commercially suitable.
    Type: Application
    Filed: January 5, 2009
    Publication date: May 28, 2009
    Applicants: DR. REDDY'S LABORATORIES LIMITED, DR. REDDY'S LABORATORIES, INC.
    Inventors: Manne Satyanarayana Reddy, Thirumalai Rajan Srinivasan, Venka Bhaskara Rao Uppala, Mummadi Venkatesh, Akundi Surya Prabhakar
  • Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof
    Patent number: 7488729
    Abstract: The present invention is related to crystalline forms of ziprasidone and its hydrochloride salt and an amorphous form of ziprasidone hydrochloride and the process for the preparation thereof. The crystalline forms and amorphous form of the invention are suitable for pharmaceutical purposes in the treatment of psychosis. The processes of the invention are simple, non-hazardous and commercially suitable.
    Type: Grant
    Filed: December 4, 2003
    Date of Patent: February 10, 2009
    Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
    Inventors: Manne Satyanarayana Reddy, Thirumalai Rajan Srinivasan, Venka Bhaskara Rao Uppala, Mummadi Venkatesh, Akundi Surya Prabhakar
  • Polymorphic forms of dihydrochloride salts of cetirizine and processes for preparation thereof
    Publication number: 20040186112
    Abstract: The present invention relates to crystalline and amorphous forms of dextrorotatory dihydrochloride salt of cetirizine, the process for the preparation thereof and compositions containing the same. The invention also relates to the crystalline and amorphous forms of levorotatory dihydrochloride salt of cetirizine, the process for the preparation thereof and compositions containing the same. Both crystalline and amorphous salt forms of cetirizine dihydrochloride are suitable for pharmaceutical purposes in the treatment of allergies, including ailments such as chronic and acute allergic rhinitis, allergic conjunctivitis, pruritus, urticaria and the like.
    Type: Application
    Filed: December 4, 2003
    Publication date: September 23, 2004
    Applicants: DR. REDDY'S LABORATORIES LIMITED, DR. REDDY'S LABORATORIES, INC.
    Inventors: Manne Satyanarayana Reddy, Thirumalai Rajan Srinivasan, Venkata Bhaskara Rao Uppala, Pattabhi Ramayya Vaddadi, Rajender Joga
  • Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof
    Publication number: 20040152711
    Abstract: The present invention is related to crystalline forms of ziprasidone and its hydrochloride salt and an amorphous form of ziprasidone hydrochloride and the process for the preparation thereof. The crystalline forms and amorphous form of the invention are suitable for pharmaceutical purposes in the treatment of psychosis. The processes of the invention are simple, non-hazardous and commercially suitable.
    Type: Application
    Filed: December 4, 2003
    Publication date: August 5, 2004
    Applicants: DR. REDDY'S LABORATORIES LIMITED, DR. REDDY'S LABORATORIES, INC.
    Inventors: Manne Satyanarayana Reddy, Thirumalai Rajan Srinivasan, Venka Bhaskara Rao Uppala, Mummadi Venkatesh, Akundi Surya Prabhakar