Abstract: A filtering face-piece respirator 10 that includes a reusable harness 19, a reusable frame 16, and a replaceable filtering structure 18. The reuseable frame 16 has the reusable harness 14 secured to it and has first and second opposing panels 28a, 28b that define a slot 38 into which the replaceable filtering structure 18 can be manually inserted to be joined to the reusable frame 16 in a removable fashion. The replaceable filtering structure 18 also is able to be separated from the reusable frame 16 by being manually withdrawn from the slot 38. The respirator provides a convenient method for reusing all respirator ports but the filtering structure while protecting the reusable parts from exposure to contaminants.