Patents by Inventor Thole Zuchner

Thole Zuchner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9976135
    Abstract: The present invention relates to a polypeptide consisting of or comprising a variant of human trypsinogen-1, comprising the substitutions: amino acid residue E64 is replaced with an amino acid residue comprising a positively charged side chain, amino acid residue K123 is replaced with an amino acid residue comprising an aliphatic side chain and amino acid residues Y139 and D147 are replaced with a glutamine or asparagine residue, and wherein said variant is further characterized in that: an amino acid residue selected from E16, E17 and E142 is replaced with an amino acid residue comprising an aliphatic side chain, and/or amino acid residue N18 is replaced with a histidine residue, and/or amino acid residue R107 is replaced with a lysine residue, and/or amino acid residue D138 is replaced with an amino acid residue comprising a positively charged side chain, and wherein said variant is cleavable into a polypeptide having a native-like enzymatic activity when compared to human trypsin-1.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: May 22, 2018
    Assignee: LIFE SCIENCE INKUBATOR GMBH
    Inventors: Karin Büttner, Agneta Prasse, Thole Zuchner
  • Publication number: 20160376630
    Abstract: The present invention relates to a method for determining an amount of a peroxide in a sample, wherein the method comprises the steps of: —providing a sample, —contacting the sample with a terbium(III) benzene dicarboxylic acid complex, and —determining the luminescence of the terbium(III) benzene dicarboxylic acid complex.
    Type: Application
    Filed: July 1, 2014
    Publication date: December 29, 2016
    Applicant: UNIVERSITAT LEIPZIG
    Inventors: Thomas KREISING, Agneta PRASSE, Kristin ZCHARNACK, Thole ZUCHNER
  • Publication number: 20160237419
    Abstract: The present invention relates to a polypeptide consisting of or comprising a variant of human trypsinogen-1, comprising the substitutions: amino acid residue E64 is replaced with an amino acid residue comprising a positively charged side chain, amino acid residue K123 is replaced with an amino acid residue comprising an aliphatic side chain and amino acid residues Y139 and D147 are replaced with a glutamine or asparagine residue, and wherein said variant is further characterized in that: an amino acid residue selected from E16, E17 and E142 is replaced with an amino acid residue comprising an aliphatic side chain, and/or amino acid residue N18 is replaced with a histidine residue, and/or amino acid residue R107 is replaced with a lysine residue, and/or amino acid residue D138 is replaced with an amino acid residue comprising a positively charged side chain, and wherein said variant is cleavable into a polypeptide having a native-like enzymatic activity when compared to human trypsin-1.
    Type: Application
    Filed: September 25, 2014
    Publication date: August 18, 2016
    Applicant: UNIVERSITAT LEIPZIG
    Inventors: Karin BUTTNER, Agneta PRASSE, Thole ZUCHNER
  • Publication number: 20150285814
    Abstract: The present invention relates to a method for preparation of a 2-chloro-1,10-phenanthrolinamine, comprising the steps: i) conversion of a 2-chloro-1,10-phenanthroline to a 2-chloro-nitro-1,10-phenanthroline characterized by a formula 2, j) hydrogenation of said 2-chloro-nitro-1,10-phenanthroline characterized by formula 5 to a 2-chloro-1,10-phenanthrolinaminecharacterized by formula 3. The present invention relates further to a method for preparation of a 2-[2-[bis(carboxymethyl)amino]ethyl-[2-[carboxymethyl-[2-[4-[2-(isothiocyanato-1,10-phenanthrolin-2-yl)ethynyl]anilino]-2-oxo-ethyl]amino]ethyl]amino]acetic acidcharacterized by formula 7 and a method for quantifying a biomolecule in a sample.
    Type: Application
    Filed: November 8, 2013
    Publication date: October 8, 2015
    Applicant: UNIVERSITÄT LEIPZIG
    Inventors: Thole Zuchner, Thomas Kreisig, Constance Nurnberger, Frank Schumer, Ralf Hoffmann
  • Publication number: 20110111388
    Abstract: The invention relates to a method for the detection of an analyte containing polyamino acid. The object of the invention is to detect polyamino acids in a highly sensitive manner. The object is achieved in that an LM is coupled to a protein after chemical activation, and is complexed using a lanthanoid ion. In order to detect polyamino acids, the time resolved fluorescence measurement is utilized after electrophoretic separation. The detection limit is 0.5 pg per spot (bovine serum albumin), wherein the linear region extends across six orders of magnitude. The invention also relates to analytes containing nucleic acid.
    Type: Application
    Filed: January 24, 2009
    Publication date: May 12, 2011
    Inventors: Horst Hennig, Ralf Hoffmann, Jörg Marx, Frank Schumer, Johannes Zeiser, Thole Züchner