Abstract: The present invention relates generally to the field of pharmaceutical formulations of antibodies. Specifically, the present invention relates to a high concentration antibody formulation and its pharmaceutical preparation and use. This invention is exemplified by a formulation of an anti-IL-7R antibody.

Abstract: A gasket is provided with a metallic substrate formed from a flat sheet of metal and is deformed to provide a raised beam portion that creates a load bearing compression limiting feature to control stresses on the over molded gasket material.

Abstract: A gasket is provided with a metallic or plastic substrate formed to provide a raised bead portion that has a concave surface that is filled with over molded elastomeric material to create a load bearing compression limiting feature to control compression on the over molded gasket material.

Abstract: A T-joint gasket assembly for sealing a first surface, a second surface adjacent to the first surface and a third surface intersecting the first and second surfaces, said first, second and third surfaces generally forming a T-joint, said T-joint being sealed absent an external sealant such as an RTV sealant agent, said gasket assembly comprising: a first gasket member which has at the ends thereof a plurality of sealing beads and at least one sealing finger, a second gasket member positioned generally coextensive with said third surface, and being oriented so as to provide a T-joint like connection with said first gasket member, with both the first gasket member and the second gasket member including a supportable elastomeric sealing material to carry out the gasket sealing, said second gasket member possessing a plurality of elastomeric sealing pads thereon, said sealing beads and said sealing finger of the first gasket member being provided to make sealing contact with said sealing pads on said second gaske

Abstract: A static gasket for sealing mating flanges which are clamped together by at least one fastener. A carrier holds the seal in a groove and the seal is protected from over compression by a compression limiter which is inserted into an aperture in the carrier. The compression limiter is crescent shaped to permit the insertion of a fastener stud into a through hole formed between the compression limiter and the aperture in the carrier.

Abstract: A gasket assembly for use in an automotive engine for sealing a T-joint or multi-joint assembly without the use of a secondary sealing media such as RTV. The gasket assembly including a first gasket having a core member, having a plurality of orifices. A seal member attached to the side of the core member. At least one sealing bead extending from an end of the seal member, at least one of the sealing beads engaging with a sealing pad attached to a second gasket to form a T-joint between an engine block, an oil pan and front cover.

Abstract: The present invention is a gasket assembly for sealing a gap between adjacent surfaces of mating components. The gasket assembly includes a core member having at least one opening extending therethrough. The gasket assembly also includes at least one seal member disposed in and circumscribing the opening. The gasket assembly further includes a plurality of tab members extending alternatingly into the opening for supporting the seal member between the tab members and within the opening.