Abstract: A chuck assembly includes a chuck base configured to interface with a spindle of a machine tool, a cartridge including a receiving opening for receiving a workpiece to be worked using the machine tool, and clamping jaws disposed proximate to a working end of the chuck base to hold the cartridge therebetween. The cartridge further comprises a multi-axis clamping and locating assembly that simultaneously positions the workpiece and clamps the workpiece responsive to insertion of the workpiece into the receiving opening such that at least a portion of the workpiece that is to be worked via the machine tool is aligned with an axis of rotation of the chuck assembly.