Patents by Inventor Thomas A. Comery

Thomas A. Comery has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for enhancing cognitive function
    Publication number: 20080032965
    Abstract: Pharmaceutical compositions and compositions are provided for treating cognitive disorders using synergistically effective amounts of 5-HT1A receptor antagonists and cognition enhancers.
    Type: Application
    Filed: June 7, 2007
    Publication date: February 7, 2008
    Inventors: Warren Hirst, Thomas Comery, Suzan Aschmies, Sharon Rosenzweig-Lipson, Lee Schechter
  • Knock in transgenic mammal containing a non-functional N-terminus of Kv beta 1.1 subunit
    Publication number: 20030024001
    Abstract: This invention provides a transgenic mammal containing a defective beta 1 subunit (Kv&bgr;1) of a voltage sensitive potassium channel, where the Kv&bgr;1 subunit is unable to confer N-type inactivation of the K+ but retains the ability to co-associate with Kv1 family &agr;-subunits and thereby enhance channel surface expression. Preferably the Kv&bgr;1.1 gene encoding Kv&bgr;1 subunit has a mutation in all or a portion of codons 1-70 of its inactivation domain. The transgenic mammal is useful as a model for psychiatric and neurological disorders to identify anxiolytic compounds and pro-cognitive functions. The invention also provides for methods for screening and evaluating test compounds for their ability to modulate Kv&bgr;1.1 activity, specifically for inactivation of a potassium channel or for co-association with &agr;-subunits.
    Type: Application
    Filed: July 16, 2002
    Publication date: January 30, 2003
    Applicant: Wyeth
    Inventors: Seung P. Kwak, Kenneth Rhodes, Karen L. Marquis, Thomas A. Comery, Roger Askew, Michael Brandt, Sharon Rosenzweig-Lipson