Patents by Inventor Thomas A. Dobson

Thomas A. Dobson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4524259
    Abstract: The impact pins of a matrix printhead are brazed by a laser to a print hammer of the flat spring type. The print hammers are then attached to a printhead mounting block adjacent to each other with the impact pins in substantially a straight line. The attached print hammers are then shaped by an electric discharge machining (EDM) process by a single electrode to simultaneously machine the impact pins to the desired shape and to position the tips of the impact pins at a precise distance with respect to one another.
    Type: Grant
    Filed: April 4, 1983
    Date of Patent: June 18, 1985
    Assignee: Dataproducts Corporation
    Inventors: Peter H. Wolf, Thomas A. Dobson, Rafael Rozo
  • Patent number: 4351942
    Abstract: A process applicable to the preparation of a wide variety of novel polycyclic heterocycles having a newly-formed pyran ring is disclosed. According to the process an aromatic nucleus bearing an ethanol group, for example, 3,4-dimethoxyphenethyl alcohol, is condensed with an aldehyde or ketone or a protected aldehyde or ketone, for example, aminoactaldehyde diethyl acetal, in the presence of an acid catalyst to afford the polycyclic heterocycle, for example, 6,7-dimethoxy-1-isochromanmethylamine. The new heterocycles so formed are useful for preparing derivatives having antiinflammatory, antibacterial or antifungal activities.
    Type: Grant
    Filed: January 7, 1980
    Date of Patent: September 28, 1982
    Assignee: American Home Products Corp.
    Inventors: Thomas A. Dobson, Leslie G. Humber, Christopher A. Demerson, Ivo L. Jirkovsky
  • Patent number: 4223151
    Abstract: A process applicable to the preparation of a wide variety of novel polycyclic heterocycles having a newly-formed pyran ring is disclosed. According to the process an aromatic nucleus bearing an ethanol group, for example, 3,4-dimethoxyphenethyl alcohol, is condensed with an aldehyde or ketone or a protected aldehyde or ketone, for example, aminoactaldehyde diethyl acetal, in the presence of an acid catalyst to afford the polycyclic heterocycle, for example, 6,7-dimethoxy-1-isochromanmethylamine. The new heterocycles so formed are useful for preparing derivatives having antiinflammatory, antibacterial or antifungal activities.
    Type: Grant
    Filed: February 3, 1977
    Date of Patent: September 16, 1980
    Assignee: American Home Products Corporation
    Inventors: Thomas A. Dobson, Leslie G. Humber, Christopher A. Demerson, Ivo L. Jirkovsky
  • Patent number: 4128560
    Abstract: Tricyclic alkylamines, and their acid addition salts with pharmaceutically acceptable acids, are disclosed. The tricyclic ring system for these compounds is selected from the group consisting of 1,2,3,4-tetrahydrocyclopent[b]indole, 1,2,3,4-tetrahydrocarbazole and 5,6,7,8,9,10-hexahydrocyclohept[b]indole. The compounds are characterized further in that the ring system carbon atom bearing the alkylamine residue is carbon atom 3, 1 and 6 in the respective ring systems and in each case the said carbon atom also is substituted with a lower alkyl. The tricyclic alkylamines are useful antidepressant agents. Methods for their preparation and use are disclosed.
    Type: Grant
    Filed: April 12, 1976
    Date of Patent: December 5, 1978
    Assignee: Ayerst McKenna & Harrison Ltd.
    Inventors: Andre A. Asselin, Leslie G. Humber, Thomas A. Dobson
  • Patent number: 4121517
    Abstract: A type bearing band assembly for use in a high speed impact printer comprising a flexible band having a plurality of cylindrical slugs secured to the band outer surface and extending across the width thereof. Each slug has end faces which open into bores or cavities extending axially into the slug. A plurality of type modules are provided, each including a head having front and rear faces. One or more raised type characters are formed on each module front face. A shank extends from each module rear face through a slug end face and is secured in the slug cavity.
    Type: Grant
    Filed: November 24, 1976
    Date of Patent: October 24, 1978
    Assignee: Dataproducts Corporation
    Inventor: Thomas A. Dobson
  • Patent number: 4118394
    Abstract: Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indone nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives having the amino(lower)alkyl radical only at position 9 possess two substituents at position 1 and may be optionally substituted at position 3, 4, 5, 6, 7, and 8. The derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7 and 8.
    Type: Grant
    Filed: August 8, 1977
    Date of Patent: October 3, 1978
    Assignee: Ayerst, McKenna & Harrison Limited
    Inventors: Christopher A. Demerson, Leslie G. Humber, Andre A. Asselin, Ivo Jirkovsky, Thomas A. Dobson
  • Patent number: 4076831
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole or 1,3,4,9-tetrahydrothiopyrano[3,4-b]indole nucleus bearing a substituent in position 1, said substituent incorporating an acid, ester or amide function therein, are disclosed. The nucleus is further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives are useful antiinflammatory, analgesic, antibacterial and antifungal agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: December 13, 1976
    Date of Patent: February 28, 1978
    Assignee: American Home Products Corporation
    Inventors: Christopher A. Demerson, Leslie G. Humber, Thomas A. Dobson, Ivo L. Jirkovsky
  • Patent number: 4070371
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole or 1,3,4,9-tetrahydrothiopyrano[3,4-b]indole nucleus bearing a substituent in position 1, said substituent incorporating an acid, ester or amide function therein, are disclosed. The nucleus is further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives are useful antiinflammatory, analgesic, antibacterial and antifungal agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: December 13, 1976
    Date of Patent: January 24, 1978
    Assignee: American Home Products Corporation
    Inventors: Christopher A. Demerson, Leslie G. Humber, Thomas A. Dobson, Ivo L. Jirkovsky
  • Patent number: 4066780
    Abstract: Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of a pyrano[4,3-b]indole or thiopyrano[4,3-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7,8, and 9.
    Type: Grant
    Filed: October 28, 1976
    Date of Patent: January 3, 1978
    Assignee: Ayerst McKenna and Harrison Ltd.
    Inventors: Christopher A. Demerson, Leslie G. Humber, Andre A. Asselin, Ivo Jirkovsky, Thomas A. Dobson
  • Patent number: 4066779
    Abstract: Pyranolindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of pyrano[4,3-b]indole or thiopyrano[4,3-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7,8, and 9.
    Type: Grant
    Filed: October 28, 1976
    Date of Patent: January 3, 1978
    Assignee: Ayerst, McKenna and Harrison Ltd.
    Inventors: Christopher A. Demerson, Leslie G. Humber, Andre A. Asselin, Ivo Jirkovsky, Thomas A. Dobson
  • Patent number: 4066763
    Abstract: Thiazinoindole derivatives characterized by having an amino(lower)alkyl radical attached to the 1 position of a 1H-1,4-thiazino[4,3-a]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated in a heterocyclic amine radical. The derivatives are substituted further at positions 1 and 10 and may be optionally substituted at positions 3, 4, 6, 7, 8 and 9. The thiazinoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the use of these derivatives and compositions containing them are also disclosed.
    Type: Grant
    Filed: December 13, 1976
    Date of Patent: January 3, 1978
    Assignee: Ayerst McKenna and Harrison Ltd.
    Inventors: Christopher A. Demerson, Leslie G. Humber, George Santroch, Thomas A. Dobson, Ivo Jirkovsky
  • Patent number: 4057559
    Abstract: Tetrahydrocyclopent[b]indole-3-acetic acid, tetrahydrocarbazole-1-acetic acid and hexahydrocyclohept[b]-indole-6-acetic acid derivatives in which the carbon bearing alkyl, lower alkenyl or lower cycloalkyl are disclosed. The compounds are useful antiinflammatory agents and methods for their preparation and use are described.
    Type: Grant
    Filed: May 7, 1975
    Date of Patent: November 8, 1977
    Assignee: American Home Products Corporation
    Inventors: Andre A. Asselin, Leslie G. Humber, Thomas A. Dobson
  • Patent number: 4056538
    Abstract: Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[ 3,4-b]indole or thiopyrano[3,4-b]indole nucleus are disclosed. The amino position of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives having the amino(lower)alkyl radical only at position 9 posses two substituents at position 1 and may be optionally substituted at position 3, 4, 5, 6, 7, and 8. The derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7 and 8.
    Type: Grant
    Filed: October 18, 1976
    Date of Patent: November 1, 1977
    Assignee: Ayerst, McKenna & Harrison Limited
    Inventors: Christopher A. Demerson, Leslie G. Humber, Andre A. Asselin, Ivo Jirkovsky, Thomas A. Dobson
  • Patent number: 4056537
    Abstract: Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives having the amino(lower)alkyl radical only at position 9 possess two substituents at position 1 and may be optionally substituted at position 3, 4, 5, 6, 7, and 8. The derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7 and 8.
    Type: Grant
    Filed: October 18, 1976
    Date of Patent: November 1, 1977
    Assignee: Ayerst McKenna and Harrison Ltd.
    Inventors: Christopher A. Demerson, Leslie G. Humber, Andre A. Asselin, Ivo Jirkovsky, Thomas A. Dobson
  • Patent number: 4041169
    Abstract: Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of a pyrano[4,3-b]indole or thiopyrano[4,3-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7,8, and 9.
    Type: Grant
    Filed: October 28, 1976
    Date of Patent: August 9, 1977
    Assignee: Ayerst McKenna and Harrison Ltd.
    Inventors: Christopher A. Demerson, Leslie G. Humber, Andre A. Asselin, Ivo Jirkovsky, Thomas A. Dobson
  • Patent number: 4036842
    Abstract: A process applicable to the preparation of a wide variety of novel polycyclic heterocycles having a newly formed pyran ring is disclosed. According to the process an aromatic nucleus bearing an ethanol group, for example, 3,4-dimethoxyphenethyl alcohol, is condensed with an aldehyde or ketone or a protected aldehyde or ketone, for example, aminoactaldehyde diethyl acetal, in the presence of an acid catalyst to afford the polycyclic heterocycle, for example, 6,7-dimethoxy-l-isochromanmethylamine. The new heterocycles so formed are useful for preparing derivatives having antiinflammatory, antibacterial or antifungal activities.
    Type: Grant
    Filed: September 15, 1975
    Date of Patent: July 19, 1977
    Assignee: American Home Products Corporation
    Inventors: Thomas A. Dobson, Leslie G. Humber, Christopher A. Demerson, Ivo L. Jirkovsky
  • Patent number: 4021451
    Abstract: A process applicable to the preparation of a wide variety of novel polycyclic heterocycles having a newly-formed pyran ring is disclosed. According to the process an aromatic nucleus bearing an ethanol group, for example, 3,4-dimethoxyphenethyl alcohol, is condensed with an aldehyde or ketone or a protected aldehyde or ketone, for example, aminoactaldehyde diethyl acetal, in the presence of an acid catalyst to afford the polycyclic heterocycle, for example, 6,7-dimethoxy-1-isochromanmethylamine. The new heterocycles so formed are useful for preparing derivatives having antiinflammatory, antibacterial or antifungal activities.
    Type: Grant
    Filed: June 5, 1975
    Date of Patent: May 3, 1977
    Assignee: American Home Products Corporation
    Inventors: Thomas A. Dobson, Leslie G. Humber, Christopher A. Demerson, Ivo L. Jirkovsky
  • Patent number: 4012417
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole or 1,3,4,9-tetrahydrothiopyrano[3,4-b]indole nucleus bearing a substituent in position 1, said substituent incorporating an acid, ester or amide function therein, are disclosed. The nucleus is further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives are useful antiinflammatory, analgesic, antibacterial and antifungal agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: March 5, 1975
    Date of Patent: March 15, 1977
    Assignee: American Home Products Corporation
    Inventors: Christopher A. Demerson, Leslie G. Humber, Thomas A. Dobson, Ivo L. Jirkovsky
  • Patent number: 4012511
    Abstract: Oxazinoindole derivatives characterized by having an amino(lower)alkyl radical attached to the 1 position of a 1H-1,4-oxazino[4,3-a]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated in a heterocyclic amine radical. The derivatives are substituted further at positions 1 and 10 and may be optionally substituted at positions 3, 4, 6, 7, 8 and 9. The oxazinoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the use of these derivatives and compositions containing them are also disclosed.
    Type: Grant
    Filed: July 7, 1975
    Date of Patent: March 15, 1977
    Assignee: Ayerst McKenna & Harrison Ltd.
    Inventors: Christopher A. Demerson, Leslie G. Humber, George Santroch, Thomas A. Dobson, Ivo Jirkovsky
  • Patent number: 4003913
    Abstract: Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of a pyrano[4,3-b]indole or thiopyrano[4,3-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7,8, and 9.
    Type: Grant
    Filed: March 5, 1975
    Date of Patent: January 18, 1977
    Assignee: Ayerst McKenna and Harrison Ltd.
    Inventors: Christopher A. Demerson, Lesie G. Humber, Andre A. Asselin, Ivo Jirkovsky, Thomas A. Dobson