Abstract: This document discusses trajectory guides that include an instrument guide with at least one lumen angled with respect to an orthogonal or other through-axis. In one example, patterned lumens on the instrument guide provide a mirror image pattern of trajectory axes intersecting a target plane. In another example, height adjustment of the instrument guide extends these or other targeting techniques to a three-dimensional volume. This document also describes a method of manufacturing such an instrument guide, which is also applicable to manufacturing an instrument guide providing parallel lumens.

Abstract: Bone marrow stromal cells (BMSC) differentiate into neuron-like phenotypes in vitro and in vivo, engrafted into normal or denervated rat striatum. The BMSC did not remain localized to the site of the graft, but migrated throughout the brain and integrated into specific brain regions in various architectonic patterns. The most orderly integration of BMSC was in the laminar distribution of cerebellar Purkinje cells, where the BMSC-derived cells took on the Purkinje phenotype. The BMSC exhibited site-dependent differentiation and expressed several neuronal markers including neuron-specific nuclear protein, tyrosine hydroxylase and calbindin. BMSC can be used to target specific brain nuclei in strategies of neural repair and gene therapy.

Abstract: This document discusses trajectory guides that include an instrument guide with at least one lumen angled with respect to an orthogonal or other through-axis. In one example, patterned lumens on the instrument guide provide a mirror image pattern of trajectory axes intersecting a target plane. In another example, height adjustment of the instrument guide extends these or other targeting techniques to a three-dimensional volume. This document also describes a method of manufacturing such an instrument guide, which is also applicable to manufacturing an instrument guide providing parallel lumens.

Abstract: The present invention provides both a device and a method. The device is a human made replacement for the soft discs in the spine. A fabric pouch encloses a central hydraulic element made up of small soft beads. Two pouches with beads are implanted into a prepared disc space to function as an intervertebral disc. The method is conversion of the device into a fusion element.

Abstract: A trainable record searcher is described. The trainable record searcher includes an iterative rules engine including at least an existing knowledge set, a plurality of rules, developed and entered to the iterative rules engine by at least one expert in at least one field of interest, a plurality of records for review by the iterative rules engine, where the plurality of rules are iteratively applied by the iterative rules engine to at least one training record. Also, the iterative application of the plurality of rules results in at least one rule modification in accordance with the existing knowledge set, where the plurality of rules, including the at least one rule modification, are applied by the iterative rules engine to a batch selected from the plurality of records to assess a compliance level for the batch of the plurality of records.

Abstract: The present invention makes a grid array, for use in the transplantation of materials into the brain, in the shape of a predetermined structure, such as the putamen, based on anatomic analysis the structure. Alternatively, a smaller grid array is used which only includes the putamen target and not the caudate target, and also has two windows within the grid array. Because of the smaller size of this grid array as well as the two cutouts in the middle, it is possible for the first time to observe the brain as the needle enters the brain through the grid array. The previous solid and larger grid array made the passage of the needle into the brain a blind maneuver. Therefore if there was cortical bleeding at the time of needle insertion, it would not be known until after the transplant was done.

Abstract: Bone marrow stromal cells (BMSC) differentiate into neuron-like phenotypes in vitro and in vivo, engrafted into normal or denervated rat striatum. The BMSC did not remain localized to the site of the graft, but migrated throughout the brain and integrated into specific brain regions in various architectonic patterns. The most orderly integration of BMSC was in the laminar distribution of cerebellar Purkinje cells, where the BMSC-derived cells took on the Purkinje phenotype. The BMSC exhibited site-dependent differentiation and expressed several neuronal markers including neuron-specific nuclear protein, tyrosine hydroxylase and calbindin. BMSC can be used to target specific brain nuclei in strategies of neural repair and gene therapy.

Abstract: Bone marrow stromal cells (BMSC) differentiate into neuron-like phenotypes in vitro and in vivo, engrafted into normal or denervated rat striatum. The BMSC did not remain localized to the site of the graft, but migrated throughout the brain and integrated into specific brain regions in various architectonic patterns. The most orderly integration of BMSC was in the laminar distribution of cerebellar Purkinje cells, where the BMSC-derived cells took on the Purkinje phenotype. The BMSC exhibited site-dependent differentiation and expressed several neuronal markers including neuron-specific nuclear protein, tyrosine hydroxylase and calbindin. BMSC can be used to target specific brain nuclei in strategies of neural repair and gene therapy.

Abstract: A portable gold mining dredge for use in collecting potentially gold containing aggregate from streambeds for subsequent classification and separation. The dredge has a receptacle, comprised of a drum with a water-tight lid, for receiving the aqueous dredged aggregate. The receptacle is of a size suitable for carrying. A self-priming pump having an inlet port and an outlet port is attached to the receptacle. A dip tube extends into the receptacle, the outer end of the dip tube being connected to the inlet port of the pump by a conduit. A suction tube communicates with the interior of the receptacle. Hoses are connected to the inlet of the suction tube and to the outlet port of the pump. During operation the suction hose is used to suck up aqueous aggregate from a streambed and the discharge hose is used to wash aggregate from cracks and crevices in rocks.

Abstract: A film advancement indicator which includes an optical sensor 21 that detects the rotational movement of a disc 18 that rotates only when the film 14 advances. When the film 14 does not advance, an indicator light 29 is activated. A counter 26 is included in the electronic circuit to determine the number of film frames advanced.

Abstract: A pressurized game ball including an air-permeable elastomeric wall defining a cavity containing a compressible inflation gas with the improvement being that the inflation gas includes predetermined mixed amounts of air and sulfur hexafluoride (SF.sub.6) gas which effectively enables the ball to retain its pressurized state within a desired range of pressures for a period of time significantly longer than the ball would remain pressurized if the inflation gas were air alone.