Patents by Inventor Thomas A. Gardner

Thomas A. Gardner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110011091
    Abstract: This invention relates generally to energy and more particularly to a method, hitherto unknown, to create kinetic energy of a body of mass. It is excessively well know in classical physics that energy can not be created or destroyed. The word create as used herein shall mean to make present about the surface of the earth energy which was previously was not present. The source of the kinetic energy shall be due to a combination of earth's gravity effects acting through a displacement. The new use and method for creating kinetic energy shall be by situating an EPICYCLOID ROLLING RESISTANCE ABATEMENT MEANS (U.S. Pat. No. 4,878,525) on an inclined surface on or about the earth's surface. Epicycloid rolling resistance abatement means art provides means of rolling resistance abatement for vehicle wheels by means of sequaciously storing and releasing energy by way of compression springs attached in a recessed manner to the periphery of a vehicle wheel.
    Type: Application
    Filed: July 14, 2009
    Publication date: January 20, 2011
    Inventor: Thomas A. Gardner
  • Publication number: 20030213006
    Abstract: The present invention relates to promoters, enhancers and other regulatory elements that direct expression within tumor cells, comprising nucleotide sequences from the 5′ regulatory region, and transcriptionally active fragments thereof, that control expression of a testicular carcinoma related protein, &bgr;-HCG. Specifically provided are expression vectors, host cells and transgenic animals wherein an &bgr;-HCG regulatory region is capable of controlling expression of a heterologous gene, over-expressing an endogenous gene or an inhibitor of a pathological process or knocking out expression of a specific gene believed to be important in cancer development and/or progression. The invention also relates to methods for using said vectors, cells and animals for screening candidate molecules for agonists and antagonists of cancer development and/or progression.
    Type: Application
    Filed: March 31, 2003
    Publication date: November 13, 2003
    Inventors: Ri-Hyun Back, Thomas A. Gardner, Akinobu Gotoli
  • Publication number: 20020052041
    Abstract: The present invention relates to methods for the production of high titers of serum-free lytic viruses in a hollow fiber cartridge capillary system. The invention further relates to methods of infecting target cells at high multiplicity and for producing high concentrations of transduced target cells.
    Type: Application
    Filed: September 6, 2001
    Publication date: May 2, 2002
    Applicant: University of Virginia Patent Foundation.
    Inventors: Leland W.K. Chung, Thomas A. Gardner, Chinghai Kao, Song-Chu Ko
  • Patent number: 6342384
    Abstract: The present invention relates to methods for the production of high titers of serum-free lytic viruses in a hollow fiber cartridge capillary system. The invention further relates to methods of infecting target cells at high multiplicity and for producing high concentrations of transduced target cells.
    Type: Grant
    Filed: November 17, 1998
    Date of Patent: January 29, 2002
    Assignee: The University of VA Patent Foundation
    Inventors: Leland W. K. Chung, Thomas A. Gardner, Chinghai Kao, Song-Chu Ko
  • Publication number: 20010038834
    Abstract: Homing bone marrow cells deposited at ATTC CRL-12424 can be transfected with a toxic gene which expresses a compound which alone, or in the company of a triggering agent, kills neighboring cancer cells in the bone marrow of a patient receiving the therapy. Toxic genes include cytotoxin such as thymidine kinase, immune stimulating compounds such as interleuken-2 and radiation repair inhibitors, such as Ku protein. The transfected cells can be administered directly to the site of the tumor or systemically, or regionally, intramedullary (into the marrow) through intravascular administration. The latter alternative permits the delivery of very high doses of the effective agent.
    Type: Application
    Filed: June 24, 1998
    Publication date: November 8, 2001
    Inventors: GARY BALIAN, QUANJUN CUI, LELAND W.K. CHUNG, CHINGHAI KAO, THOMAS A. GARDNER
  • Patent number: 5010632
    Abstract: A descaling tool for use with a reciprocating hammer for removing foreign substances from metal, wood, stone, or the like. The tool is comprised of an elongated shank, one end having an adapter for receipt into a reciprocating hammer, the other having a bore therein for receiving a bundle of elongated, resilient descaling members. The shank is encased by a sleeve and handle assembly which is used to adjust the exposed portion of the descaling members.
    Type: Grant
    Filed: April 2, 1990
    Date of Patent: April 30, 1991
    Inventor: Thomas A. Gardner
  • Patent number: 4878525
    Abstract: In combination with vehicle wheels a means for performing reduction of effective vehicle bearing weight thereby mitigating rolling resistance thereof enhancing energy efficiency. Attachment to be radially fixed on and around a vehicle wheel and configured to extend beyond the periphery of the wheel in a prolapse condition not common to wheel art. The attachment shall be displaceable and capable of energy storage and release sequaciously.Operation shall be via the nutation of the extended attachment with each nutating cycle bifurcated by the vehicle bearing weight area thereof allowing the bearing weight to be transferred to the displaceable attachments dynamically. The effective bearing weight of the vehicle is reduced and thereof deformations to the vehicle wheel and roadway are mitigated. Reduction of the deformations mitigate nonproductive energy transfer from the vehicle wheel and roadway structure.
    Type: Grant
    Filed: January 23, 1989
    Date of Patent: November 7, 1989
    Inventor: Thomas A. Gardner
  • Patent number: 4447964
    Abstract: A steam dryer system for drying a moving web and including a primary series of rotatable drying drums, steam inlet conduits coupled to said rotatable drying drums for introducing steam thereinto, outlet conduits coupled to said rotatable drying drums for exhausting blow-through steam with noncondensible gases and condensate therefrom, recirculation means including a steam jet compressor to recirculate blow-through steam from said outlet conduits back to said inlet conduits, recirculation control means comprising instruments to measure velocity pressure of the recirculation flow and to control the action of said jet compressor, a further number of secondary drying drums having inlet conduits and a pressure control valve connected to the outlet of said jet compressor and with outlet conduits connected to a condenser, and pressure control means comprising instruments to measure and control the input pressure in said secondary drying drums.
    Type: Grant
    Filed: November 23, 1981
    Date of Patent: May 15, 1984
    Inventor: Thomas A. Gardner