Patents by Inventor Thomas A. Gordy
Thomas A. Gordy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220362161Abstract: Polymeric particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene and/or a derivative thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided as color-coded microspheres or nanospheres to allow ready identification of the sized particles in use. Such color-coded microspheres or nanospheres may further be provided in like color-coded delivery or containment devices to enhance user identification and provide visual confirmation of the use of a specifically desired size of microspheres or nanospheres.Type: ApplicationFiled: July 26, 2022Publication date: November 17, 2022Inventors: Ulf FRITZ, Olaf FRITZ, Thomas A. GORDY, Ronald WOJCIK, Jaques BLÜMMEL, Alexander KÜLLER
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Patent number: 11426355Abstract: Polymeric particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene and/or a derivative thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided as color-coded microspheres or nanospheres to allow ready identification of the sized particles in use. Such color-coded microspheres or nanospheres may further be provided in like color-coded delivery or containment devices to enhance user identification and provide visual confirmation of the use of a specifically desired size of microspheres or nanospheres.Type: GrantFiled: October 7, 2020Date of Patent: August 30, 2022Assignee: Varian Medical Systems, Inc.Inventors: Ulf Fritz, Olaf Fritz, Thomas A. Gordy, Ronald Wojcik, Jaques Blummel, Alexander Kuller
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Publication number: 20220265259Abstract: Medical devices include a rigid dome, a viewing window, a vacuum port, a vacuum pressure regulator, an aperture, and a septum. The rigid dome is hemispherical and includes a first dome stage, a second dome stage distal on the first dome stage, and a transition between the first dome stage and the second dome stage. The viewing window is acoustically and\or optically transparent to allow for inspection of the surgical site. The vacuum port allows for a reduction of a pressure on the interior of the rigid dome. The vacuum pressure regulator regulates the pressure on the interior of the rigid dome. The aperture provides access to the interior of the rigid dome and the surgical site. The septum engages with the second dome stage to allow for insertion of a surgical instrument with resistance to loss of the pressure on the interior of the rigid dome.Type: ApplicationFiled: May 10, 2022Publication date: August 25, 2022Inventors: Oscar Jimenez, Thomas A. Gordy
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Publication number: 20210299056Abstract: Various embodiments are directed to color-coded and size-calibrated polymeric particles comprising an acrylate-based hydrogel core incorporating one or more chromophores of interest, and an outer shell comprising polyphosphazenes of formula I, useful for various therapeutic and/or diagnostic procedures. In various embodiments, the color-coded and size-calibrated polymeric particles can be employed in any particle-mediated procedure, including as embolic agents, dermal fillers, and various implantable devices for a broad range of clinical and cosmetic applications. The incorporation of a particular chromophore formulation that correlates with a pre-determined size specificity for implantable and loadable polymeric particles (“color-coded and size-calibrated”) enables the visual detection and identification of particles exhibiting a particular size of interest, and minimizes the probability of user-introduced or procedural errors.Type: ApplicationFiled: May 15, 2009Publication date: September 30, 2021Applicant: Varian Medical Systems, Inc.Inventors: Ulf Fritz, Olaf Fritz, Thomas A. Gordy, Ronald Wojcik, Jacques BLÜMMEL, Alexander KÜLLER
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Patent number: 10973770Abstract: Polymeric particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene and/or a derivative thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided as color-coded microspheres or nanospheres to allow ready identification of the sized particles in use. Such color-coded microspheres or nanospheres may further be provided in like color-coded delivery or containment devices to enhance user identification and provide visual confirmation of the use of a specifically desired size of microspheres or nanospheres.Type: GrantFiled: May 22, 2015Date of Patent: April 13, 2021Assignee: Varian Medical Systems, Inc.Inventors: Ulf Fritz, Olaf Fritz, Thomas A. Gordy, Ronald Wojcik, Jacques Blummel, Alexander Kuller
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Publication number: 20210023015Abstract: Polymeric particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene and/or a derivative thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided as color-coded microspheres or nanospheres to allow ready identification of the sized particles in use. Such color-coded microspheres or nanospheres may further be provided in like color-coded delivery or containment devices to enhance user identification and provide visual confirmation of the use of a specifically desired size of microspheres or nanospheres.Type: ApplicationFiled: October 7, 2020Publication date: January 28, 2021Inventors: Ulf FRITZ, Olaf FRITZ, Thomas A. GORDY, Ronald WOJCIK, Jaques BLUMMEL, Alexander KULLER
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Patent number: 9597419Abstract: Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles can also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Microspheres of the present invention may further be provided with physical and/or chemical enhancements within the particles' cores to enhance visualization of the embolized tissue using a variety of medical imaging modalities, including conventional radiography, fluoroscopy, tomography, computerized tomography, ultrasound, scintillation, magnetic resonance, or other imaging technologies.Type: GrantFiled: April 22, 2015Date of Patent: March 21, 2017Assignee: Boston Scientific LimitedInventors: Ulf Fritz, Olaf Fritz, Thomas A. Gordy, Ronald Wojcik, Jacques Blümmel, Alexander Küller
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Publication number: 20150258224Abstract: Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles can also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Microspheres of the present invention may further be provided with physical and/or chemical enhancements within the particles' cores to enhance visualization of the embolized tissue using a variety of medical imaging modalities, including conventional radiography, fluoroscopy, tomography, computerized tomography, ultrasound, scintillation, magnetic resonance, or other imaging technologies.Type: ApplicationFiled: April 22, 2015Publication date: September 17, 2015Inventors: Ulf FRITZ, Olaf Fritz, Thomas A. Gordy, Ronald Wojcik, Jacques Blümmel, Alexander Küller
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Publication number: 20150250736Abstract: Polymeric particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene and/or a derivative thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided as color-coded microspheres or nanospheres to allow ready identification of the sized particles in use. Such color-coded microspheres or nanospheres may further be provided in like color-coded delivery or containment devices to enhance user identification and provide visual confirmation of the use of a specifically desired size of microspheres or nanospheres.Type: ApplicationFiled: May 22, 2015Publication date: September 10, 2015Inventors: Ulf FRITZ, Olaf FRITZ, Thomas A. GORDY, Ronald WOJCIK, Jacques BLÜMMEL, Alexander KÜLLER
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Patent number: 9114162Abstract: Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles can also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Microspheres of the present invention may further be provided with physical and/or chemical enhancements within the particles' cores to enhance visualization of the embolized tissue using a variety of medical imaging modalities, including conventional radiography, fluoroscopy, tomography, computerized tomography, ultrasound, scintillation, magnetic resonance, or other imaging technologies.Type: GrantFiled: October 24, 2007Date of Patent: August 25, 2015Assignee: CELONOVA BIOSCIENCES, INC.Inventors: Ulf Fritz, Olaf Fritz, Thomas A. Gordy, Jacques Blümmel, Alexander Küller, Gretchen B. Wojcik
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Patent number: 9107850Abstract: Polymeric particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided as color-coded microspheres or nanospheres to allow ready identification of the sized particles in use. Such color-coded microspheres or nanospheres may further be provided in like color-coded delivery or containment devices to enhance user identification and provide visual confirmation of the use of a specifically desired size of microspheres or nanospheres.Type: GrantFiled: October 26, 2007Date of Patent: August 18, 2015Assignee: CELONOVA BIOSCIENCES, INC.Inventors: Ulf Fritz, Olaf Fritz, Thomas A. Gordy, Jacques Blümmel, Alexander Küller, Gretchen B. Wojcik
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Patent number: 7922764Abstract: This disclosure encompasses a bioprosthetic heart valve having a polyphosphazene polymer such as poly[bis(trifluoroethoxy)phosphazene], which exhibits improved antithrombogenic, biocompatibility, and hemocompatibility properties. A method of manufacturing a bioprosthetic heart valve having a polyphosphazene polymer is also described.Type: GrantFiled: October 10, 2007Date of Patent: April 12, 2011Assignee: Celonova Bioscience, Inc.Inventors: Thomas A. Gordy, Neng S. Ung, Ulf Fritz, Roman Denk
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Publication number: 20100047324Abstract: Various embodiments are directed to multi-functional wound-care dressing matrices that can protect and promote new tissue growth at a wound site. The multi-functional wound care matrix can incorporate polyphosphazenes of formula I, as a component that can be configured into various forms, including as fibrous mats, porous membranes, nonporous films, particulate formulations, and equivalents. The multi-functional wound-care dressing matrix of the present disclosure exhibit high-performance properties conferred by polyphosphazenes of formula I. Exceptional biocompatible properties of polyphosphazenes of formula I provide an ideal tissue-contacting surface for the multi-functional wound-care dressing matrix of interest.Type: ApplicationFiled: February 23, 2009Publication date: February 25, 2010Applicant: CeloNova BioSciences, Inc.Inventors: Ulf Fritz, Olaf Fritz, Thomas A. Gordy
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Publication number: 20100028260Abstract: Various embodiments are directed to color-coded and size-calibrated polymeric particles comprising an acrylate-based hydrogel core incorporating one or more chromophores of interest, and an outer shell comprising polyphosphazenes of formula I, useful for various therapeutic and/or diagnostic procedures. In various embodiments, the color-coded and size-calibrated polymeric particles can be employed in any particle-mediated procedure, including as embolic agents, dermal fillers, and various implantable devices for a broad range of clinical and cosmetic applications. The incorporation of a particular chromophore formulation that correlates with a pre-determined size specificity for implantable and loadable polymeric particles (“color-coded and size-calibrated”) enables the visual detection and identification of particles exhibiting a particular size of interest, and minimizes the probability of user-introduced or procedural errors.Type: ApplicationFiled: May 15, 2009Publication date: February 4, 2010Applicant: Celonova Biosciences, Inc.Inventors: Ulf Fritz, Olaf Fritz, Thomas A. Gordy, Ronald Wojcik, Jacques BLÜMMEL, Alexander KÜLLER
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Publication number: 20090110730Abstract: The present invention relates to the use of certain microspheres, nanospheres, and other structures to provide a method of marking or masking identifying marks in individual biological hosts. Biological hosts for the present invention may include humans, other animals, or plants. Such methods may be used to sense, signal, track, mark, or identify individual biological hosts. Microspheres, nanospheres, and other structures of the present invention may be implanted, injected, ingested, or attached to individual biological hosts. Microspheres, nanospheres, and other structures of the present invention comprise poly[bis(trifluoroethoxy)phosphazene] and/or a derivative thereof which may be present throughout the particles or within an outer coating of the particles. The microspheres, nanospheres, and other structures may also comprise a core having a hydrogel which may further comprise one or more dyes or other chromophoric agents covalently bound permanently to the hydrogel core material.Type: ApplicationFiled: October 30, 2007Publication date: April 30, 2009Applicant: CELONOVA BIOSCIENCES, INC.Inventors: Ulf Fritz, Olaf Fritz, Thomas A. Gordy, Ronald Wojcik
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Publication number: 20090110738Abstract: Particles are provided for use in therapeutic cosmetic and/or reconstructive procedures to augment defects in tissue to restore contours and/or function. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in various colors or with customized coloration to match desired tissues. Moreover, such particles may be loaded to provide localized treatment with an active component agent in specific clinical uses.Type: ApplicationFiled: October 26, 2007Publication date: April 30, 2009Applicant: CELONOVA BIOSCIENCES, INC.Inventors: Thomas A. Gordy, Olaf Fritz, Ulf Fritz, Ronald Wojcik, Teresa Wilson, Harry R. Jacobson
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Publication number: 20090111763Abstract: Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided for placement within defects in bone within the body of a mammal to augment structural support and facilitate osteogenesis without causing adverse reactions therein. The hydrogel core may further be used as a delivery vehicle for therapeutic agents to treat or retard pathologic processes within the bone defect during healing.Type: ApplicationFiled: October 26, 2007Publication date: April 30, 2009Applicant: CELONOVA BIOSCIENCES, INC.Inventors: Ulf Fritz, Olaf Fritz, Thomas A. Gordy, Ronald Wojcik
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Publication number: 20080228284Abstract: The present invention relates to expandable semi-compliant devices that may be used for the treatment of diseased or injured bone tissues, and methods of using the same. The semi-compliant device of the present invention is inserted into an interior space of a cancellous bone tissue, and is filled with a suitable material to provide internal structural support to the bone. The semi-compliant device may further comprise a polymer or a polymer surface coating of a biocompatible polyphosphazene polymer such as poly[bis-(trifluoroethoxy)phosphazene] or derivatives thereof. Such semi-compliant devices or surface coatings may also act as carriers for medicinal, radiological, or thermal treatments of diseased bone.Type: ApplicationFiled: October 24, 2007Publication date: September 18, 2008Applicant: CELONOVA BIOSCIENCES, INC.Inventors: Ulf Fritz, Olaf Fritz, Thomas A. Gordy, Goetz Martin Richter
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Publication number: 20080113029Abstract: Polymeric particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy) phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided as color-coded microspheres or nanospheres to allow ready identification of the sized particles in use. Such color-coded microspheres or nanospheres may further be provided in like color-coded delivery or containment devices to enhance user identification and provide visual confirmation of the use of a specifically desired size of microspheres or nanospheres.Type: ApplicationFiled: October 26, 2007Publication date: May 15, 2008Applicant: CELONOVA BIOSCIENCES, INC.Inventors: Ulf Fritz, Olaf Fritz, Thomas A. Gordy, Ronald Wojcik
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Publication number: 20080102029Abstract: Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles can also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Microspheres of the present invention may further be provided with physical and/or chemical enhancements within the particles' cores to enhance visualization of the embolized tissue using a variety of medical imaging modalities, including conventional radiography, fluoroscopy, tomography, computerized tomography, ultrasound, scintillation, magnetic resonance, or other imaging technologies.Type: ApplicationFiled: October 24, 2007Publication date: May 1, 2008Applicant: CELONOVA BIOSCIENCES, INC.Inventors: Ulf Fritz, Olaf Fritz, Thomas Gordy, Ronald Wojcik