Abstract: Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecules of the invention are made entirely by solid phase synthesis. In other instances, the spacer groups are hydrophilic and compositions containing them, and to solid phase synthesis of varied structure peptoids using chemoselective ligation moieties.

Abstract: A ground connector for earthing a cable having an outer jacket closely surrounding an inner conductor, the ground connector comprising a connector body, with at least one contact element for providing electrical contact between the connector body and the inner conductor of the cable, and at least one opening element so designed to cut and/or perforate the outer jacket. A method for earthing a cable with such a ground connector.

Abstract: Armature pin assemblies and methods for forming the same are described. A first portion of a pin member is placed in a die cavity so as to expose a second portion of the pin member. An amount of metal powder is placed into the die cavity so as envelope the second portion of the pin member. A press member is then brought into contact with the metal powder so as to compress the same and form an armature member. The pin member is fastened to the armature member by the press operation so as to form a unitary armature pin assembly.

Abstract: A knitted fabric female fastening portion for a mechanical fastener having a knitted fabric, an underlying substrate, a bonding layer, said bonding layer having a first plurality of non-intersecting bond lines and a second plurality of non-intersecting bond lines which are combined to form a pattern of intersecting bond lines that define tessellating pattern elements. Said pattern of intersecting bond lines may have a CD percent coverage standard deviation not equal to 0% and an MD percent coverage standard deviation not equal to 0%.

Abstract: Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecules of the invention are made entirely by solid phase synthesis. In other instances, the spacer groups are hydrophilic and compositions containing them, and to solid phase synthesis of varied structure peptoids using chemoselective ligation moieties.

Abstract: The pharmaceutical composition is useful for treating epithelial tumors in a subject and contains at least two antigens and a pharmaceutically acceptable carrier, where each of the antigens induces or is capable of inducing a cutaneous delayed type hypersensitivity (DTH) response in the subject. This composition is particularly useful in treating epithelial tumors, such as warts or verrucae, that are induced by or related to papillomavirus. Antigens useful in the present pharmaceutical composition are anergy panel antigens, such as killed mumps virus, candida extract, trichophyton extract or comparable antigenic extracts. An additional pharmaceutical composition, also useful for treating epithelial tumors, contains at least one antigen that induces or is capable of inducing a cutaneous DTH response in a subject, at least one cytokine or colony stimulating factor and a pharmaceutically acceptable carrier. Kits containing these pharmaceutical compositions are useful for this immunotherapy.

Abstract: A pulse width modulated solenoid system having low noise characteristics is described. Noise reduction is primarily achieved by separating the solenoid device from the insulator and the manifold housing through the use of rubber isolators and multiple sets of o-rings, thus preventing metal to metal contact. Additional noise reduction is achieved by encapsulating all of the solenoids, using the insulator, the cover plate, the housing, and the screen carrier. Noise levels are also further reduced by minimizing the impact force of the armature against the sleeve by allowing fluid to vent into the upper area of the sleeve, thus causing a dampening effect.

Abstract: A magazine clip exterior housing system that facilitates belt attachment of the ammunition magazine clips utilized by a variety of automatic and semi-automatic weapon systems. The housing can be removably or permanently attached over the lower half of the exterior surface of a magazine clip, and the enclosed clip can be used in the weapon system without the need to remove the housing. The housing system includes a belt clip on one side and a series of raised ribs on the other side to provide for secure clip handling. In the removably attached embodiment a groove in the interior surface guides the magazine clip into position within the apparatus. The housing is made of resilient, lightweight plastic which provides an appropriate coefficient of friction between the housing system and the user's hands, as well as an appropriate degree of durability/longevity. The device is simple, scalable, and economically manufactured.

Abstract: Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecules of the invention are made entirely by solid phase synthesis. In other instances, the spacer groups are hydrophilic and compositions containing them, and to solid phase synthesis of varied structure peptoids using chemoselective ligation moieties.

Abstract: Oligomers are prepared substantially free of error sequences by sequentially adding monomers to a growing chain bound to a support through a first selectably cleavable linkage, a first capture moiety and a second selectably cleavable linkage. At the completion of monomer addition, the completed oligomer is cleaved from the support to reveal the first capture moiety and purified by virtue of the presence of a second capture moiety, e.g., a terminal blocking group, and the first capture moiety. A support-bound oligomer having the structural formula (I) S—[X1]n1—SC1—CP2—[X2]n2—SC3—T1—X—T2—SC2—CP1  (I) is also provided wherein T1, T2, X1, X2, n1, n2, SC1, SC2, SC3, CP1 and CP2 are as defined herein.

Abstract: Methods are provided for reducing background signals encountered in nucleic acid hybridization assays and other assays that involve hybridization of a labeled oligomer to its complement. The method is premised on the significant reduction of signal generation that occurs when a quenchable dye-labeled oligomer forms a hybrid complex. In addition, a method is provided for enhancing the detectable signal emitted from an amplification multimer hybridized to an oligomer probe to which a quenchable dye has been conjugated through a linker such that the emission from the dye is not quenched upon hybrid complex formation. Novel oligonucleotide probes are also provided that comprise an oligomer to which has been directly or indirectly through a linker a quenchable dye.

Abstract: An exhaust gas recirculation system for an internal combustion engine including a valve body having an exhaust port adapted for fluid communication with a source of exhaust gas, an intake port adapted for fluid communication with the intake manifold of an internal combustion engine, and a valve member movably supported within the body between open and closed positions thereby controlling the flow of exhaust gas from the exhaust port to the intake port. A diaphragm housing is operatively mounted to the valve body and supported thereby. The diaphragm housing defines a vacuum cavity in fluid communication with a source of negative pressure and an atmosphere cavity in fluid communication with a source of second pressure. A diaphragm member is disposed between the vacuum and atmosphere cavities and is operatively connected to the valve member.

Abstract: Methods are provided for substantially reducing background signals encountered in nucleic acid hybridization assays. The method is premised on the elimination or significant reduction of the phenomenon of nonspecific hybridization, so as to provide a detectable signal which is produced only in the presence the target polynucleotide of interest. In addition, a novel method for the chemical synthesis of isoguanosine or 2′-deoxy-isoguanosine is provided. The invention also has applications in antisense and aptamer therapeutics and drug discovery.

Abstract: Methods are provided for reducing background signals encountered in nucleic acid hybridization assays and other assays that involve hybridization of a labeled oligomer to its complement. The method is premised on the significant reduction of signal generation that occurs when a quenchable dye-labeled oligomer forms a hybrid complex. In addition, a method is provided for enhancing the detectable signal emitted from an amplification multimer hybridized to an oligomer probe to which a quenchable dye has been conjugated through a linker such that the emission from the dye is not quenched upon hybrid complex formation. Novel oligonucleotide probes are also provided that comprise an oligomer to which has been directly or indirectly through a linker a quenchable dye.

Abstract: Methods are provided for substantially reducing background signals encountered in nucleic acid hybridization assays. The method is premised on the elimination or significant reduction of the phenomenon of nonspecific hybridization, so as to provide a detectable signal which is produced only in the presence the target polynucleotide of interest. In addition, a novel method for the chemical synthesis of isoguanosine or 2′-deoxy-isoguanosine is provided. The invention also has applications in antisense and aptamer therapeutics and drug discovery.

Abstract: Branched polymers and multiply connected macromolecular structures are provided, wherein the polymers and structures are provided, wherein the polymers are structures comprise at least two branches and/or macrocycles, at least one of which is a target binding moiety capable of binding to a target molecule of interest, and at least another of which is a signal generation moiety capable of directly or indirectly generating a signal. These polymers and structures contain components that are linked through sulfur-containing bridges that are selectively cleaved by oxidation, e.g. thiophosphorylacyl, dithiophosphorylacyl, thiophosphorylthio, thiophosphorylalkylamino and/or dithiophosphorylalkylamino bridges, Synthetic methods are also provided, as are kits containing a complexing buffer and a nucleic acid probe composed of the branched polymer or macromolecular structure.

Abstract: A method is indicated for applying a connecting element (3) in a moisture-proof manner to a high-frequency cable (1) containing at least one tubular electric conductor (7) which is surrounded by a sheath made of an insulating material. First, the sheath (10) is removed from the end of the conductor (7). Then a socket-shaped metal contact part (11,12) is attached to this end of the conductor (7) so that it makes electrical contact. A sealing material is placed between the contact part and conductor (7) on the one hand, and the contact part and the sheath (10) on the other. The sealing material for a seal (15) is made up of at least two components, which after the installation of the contact part (11, 12) enlarges its volume to such a degree that it fills the peripheral hollow space between the contact part (11, 12) and the conductor (7), and between the contact part (11, 12) and the sheath (10), at least in the transition area from the conductor (7) to the sheath (10).

Abstract: Novel oligonucleotides are provided having cationic internucleoside linkages. The cationic internucleoside linkage has the structure ##STR1## wherein W, X, Y, Z, R.sup.1, R.sup.2, and R.sup.3 are as defined herein, P* represents an asymmetric phosphorus atom capable of existing in two distinct stereoisomeric configurations, and further wherein the internucleoside linkage is stereouniform. Certain of these oligonucleotides may have alternating anionic and cationic internucleoside linkages, which are not necessarily stereouniform. A method for synthesizing the compounds are provided as well, as are methods for using the compounds, e.g., as antisense molecules and in nucleic acid hybridization assays.

Abstract: A fitting for fastening a cable (2) to a wall (1) is indicated, which comprises a base (6) to be fastened to the wall (1) and a cap (7). The end of the base (6) which in the installed position faces away from the wall has a trough (8) for receiving the cable (2), which in the installed position is closed by the cap (7). The base (6) has three separate faces (9, 10, 11) which form the corners of a triangle for the attachment to the wall (1). The part of the cap (7) which in the installed position is applied against the cable is elastically deformable.

Abstract: Recombinant vectors and methods for constructing ricin B are disclosed. The coding sequence for ricin B was cloned, disposed in suitable expression vectors and produced free of components normally accompanying this peptide. In addition, a novel means of reconstructing missing portions of coding sequence, and certain improvements in messenger RNA purification are disclosed.