Patents by Inventor Thomas A. Krenitsky

Thomas A. Krenitsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 5-alkynyl pyrimidines having neurotrophic activity
    Patent number: 7205297
    Abstract: The present invention relates to a series of novel substituted 5-alkynyl pyrimidines, pharmaceutical compositions which contain them, methods for their preparation, and their use in therapy, particularly in the treatment of neurodegenerative or other neurological disorders of the central and peripheral nervous systems, including age related cognitive disorders such as senility and Alzheimer's disease, nerve injuries, peripheral neuropathies, and seizure disorders such as epilepsy.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: April 17, 2007
    Assignee: Krenitsky Pharmaceuticals, Inc.
    Inventors: Lilia M. Beauchamp, Thomas A. Krenitsky, James L. Kelley
  • Neurotrophic substituted pyrimidines
    Patent number: 6916820
    Abstract: The present invention relates to a series of substituted pyrimidines, to pharmaceutical compositions which contain them, to methods for their preparation and to their use in therapy, particularly in the treatment of neurodegenerative or other neurological disorders of the central and peripheral nervous systems.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: July 12, 2005
    Assignee: Krenitsky Pharmaceuticals, Inc.
    Inventors: James L. Kelley, Thomas A. Krenitsky, Lilia M. Beauchamp
  • Substituted 5-alkynyl pyrimidines having neurotrophic activity
    Publication number: 20040087789
    Abstract: The present invention relates to a series of novel substituted 5-alkynyl pyrimidines, pharmaceutical compositions which contain them, methods for their preparation, and their use in therapy, particularly in the treatment of neurodegenerative or other neurological disorders of the central and peripheral nervous systems, including age related cognitive disorders such as senility and Alzheimer's disease, nerve injuries, peripheral neuropathies, and seizure disorders such as epilepsy.
    Type: Application
    Filed: June 27, 2003
    Publication date: May 6, 2004
    Inventors: Lilia M. Beauchamp, Thomas A. Krenitsky, James L. Kelley
  • Neurotrophic substituted pyrimidines
    Patent number: 6583148
    Abstract: The present invention relates to novel derivatives of a series of substituted pyrimidines, to pharmaceutical compositions which contain them, to methods for their preparation and to their use in therapy, particularly in the treatment of neurodegenerative or other neurological disorders of the central and peripheral systems.
    Type: Grant
    Filed: April 8, 1999
    Date of Patent: June 24, 2003
    Assignee: Krenitsky Pharmaceuticals, Inc.
    Inventors: James L. Kelley, Thomas A. Krenitsky, Lilia M. Beauchamp
  • Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
    Patent number: 6440965
    Abstract: The present invention relates to novel derivatives of a series of substituted pyrimidines, to pharmaceutical compositions which contain them, to methods for their preparation and to their use in therapy, particularly in the treatment of neurodegenerative or other neurological disorders of the central and peripheral systems.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: August 27, 2002
    Assignee: Krenitsky Pharmaceuticals, Inc.
    Inventors: James L. Kelley, Thomas A. Krenitsky, Lilia M. Beauchamp
  • Therapeutic nucleosides
    Patent number: 5637574
    Abstract: Compounds or formula (I), wherein R.sup.1 represents an n-propoxy, cyclobutoxy, cyclopropylamino, piperidino or pyrrolidino group; or a physiologically functional derivative thereof. The invention further includes methods for the preparation of compounds of formula (I), compositions containing them and the use of these compounds as antiviral agents.
    Type: Grant
    Filed: October 5, 1994
    Date of Patent: June 10, 1997
    Assignee: Glaxo Wellcome Inc.
    Inventors: Charlene L. Burns, George W. Koszalka, Thomas A. Krenitsky, Susan M. Daluge
  • Method of treating HIV infections with 2',3'-dideoxy-3'-fluoro-5-chlorouridine
    Patent number: 5574149
    Abstract: A method for treating HIV infections comprising administering a composition whose active ingredient is 2',3'-dideoxy-3'-fluoro-5'-chlorouridine.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: November 12, 1996
    Assignee: Glaxo Wellcome Inc.
    Inventors: Joel Van Tuttle, Susan M. Daluge, Charlene L. Burns, George W. Koszalka, Thomas A. Krenitsky
  • Methods of treating hepatitis B virus infection with therapeutic nucleosides
    Patent number: 5559100
    Abstract: The present invention relates to certain 2',3'-dideoxynucleosides and pharmaceutically acceptable derivatives thereof, methods for preparing them, their use in the treatment and prophylaxis of viral, especially retroviral, infections, and pharmaceutical formulations containing them.
    Type: Grant
    Filed: August 9, 1989
    Date of Patent: September 24, 1996
    Assignee: Glaxo Wellcome Inc.
    Inventors: George W. Koszalka, Thomas A. Krenitsky
  • 5'-O-propionyl and 5'-O-butyryl esters of 2-amino-6-methoxy-9-(.beta.-D-arabinofuranosyl)-9H-purine
    Patent number: 5539098
    Abstract: The 5'-O-proprionyl and 5'-O-butyryl esters of 2-amino-6-methoxy-9-(B-D-arabinofuranosyl)-9H-purine useful as inhibitors of varicella zoster virus.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: July 23, 1996
    Assignee: Glaxo Wellcome Inc.
    Inventors: Thomas A. Krenitsky, David J. T. Porter
  • Method for treating T-cell lymphoblastic leukemia with ara-G nucleoside derivatives
    Patent number: 5492897
    Abstract: 6-Alkoxy derivatives of Ara-G, and pharmaceutically acceptable esters thereof, are described as being useful in tumor therapy. Novel pharmaceutically acceptable esters, their preparation and pharmaceutical formulations containing them are also disclosed.
    Type: Grant
    Filed: April 7, 1994
    Date of Patent: February 20, 1996
    Assignee: Burroughs Wellcome Co. (141)
    Inventors: Thomas A. Krenitsky, Devron R. Averett, George W. Koszalka, Gerald Wolberg
  • 9-.beta.-D-arabinofuranasyl-2-amino-6-methaoxy-9H-purine
    Patent number: 5424295
    Abstract: The compound 9-B-D-arabinofuranosyl-2-amino-6-methoxy-9H-purine along with its 5'-acetyl and 5'-(4-methoxy-4-oxobutyryl derivatives are disclosed as inhibitors of Varicella Zoster virus (VZV).
    Type: Grant
    Filed: August 23, 1993
    Date of Patent: June 13, 1995
    Assignee: Burroughs Wellcome Co.
    Inventors: Thomas A. Krenitsky, David J. T. Porter
  • Method for the treatment of protoza infections with 2.sup.1 -deoxy-2.sup.1 -fluoropurine nucleosides
    Patent number: 5420115
    Abstract: A method for treating two specific protozoal infections, Trichomonas vaginalis and Giardia lamblia, comprising the administration to a mammal in need thereof one of the following purine nucleosides:2,6-diamino-9-(2-deoxy-2-fluoro-.beta.-D-ribofuranosyl)-9H-purine2-amino-9-(2-deoxy-2-fluoro-.beta.-D-ribofuranosyl)-9H-purine2-amino-9-(2-deoxy-2-fluoro-.beta.-D-ribofuranosyl)-6-methoxy-9H-purine.
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: May 30, 1995
    Assignee: Burroughs Wellcome Co.
    Inventors: Sylvia M. Tisdale, Joel Van Tuttle, Martin J. Slater, Susan M. Daluge, Wayne H. Miller, Thomas A. Krenitsky, George W. Koszalka
  • Treatment of adenovical infections with 3'-fluoro-5-halo uracil compounds
    Patent number: 5376644
    Abstract: 2',3'-Dideoxy-3'-fluoro pyrimidine nucleosides particularly 2', 3'-dideoxy-3'-fluorothymidine have been found to have particularly potent activity against adenovirus infections especially those caused by adenoviruses of scrotype 8. Such compounds are preferably presented in pharmaceutical formulations adapted for ophthalmic administration.
    Type: Grant
    Filed: December 24, 1992
    Date of Patent: December 27, 1994
    Assignee: Burroughs Wellcome Co.
    Inventors: John W. T. Selway, Joel Van Tuttle, Thomas A. Krenitsky
  • 5'-esters of 2',3'-dideoxy-3'-fluoro-5-ethynyluridine
    Patent number: 5198539
    Abstract: The present invention relates to a 3'-substituted pyrimidine nucleoside and its use in medical therapy, particularly in the treatment of HIV infections. Also provided are pharmaceutical formulations.
    Type: Grant
    Filed: August 15, 1991
    Date of Patent: March 30, 1993
    Assignee: Burroughs Wellcome Co.
    Inventors: Saad G. Rahim, Thomas A. Krenitsky
  • Therapeutic nucleosides
    Patent number: 5185437
    Abstract: This invention relates to certain 6-substituted 2',3'-dideoxypurine nucleosides and pharmaceutically acceptable derivatives thereof and their use in the treatment of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections. Also provided are pharmaceutical formulations and processes for the production of the compounds of the invention.
    Type: Grant
    Filed: August 31, 1991
    Date of Patent: February 9, 1993
    Assignee: Burroughs Wellcome Co.
    Inventors: George W. Koszalka, Charlene L. Burns, Thomas A. Krenitsky, Janet L. Rideout
  • Therapeutic nucleosides
    Patent number: 5175274
    Abstract: This invention relates to certain 2'-fluoro nucleosides and pharmaceutically acceptable derivatives thereof and their use in the treatment of HIV infections. Also provided are pharmaceutical formulations and processes for the production of the compounds according to the invention.
    Type: Grant
    Filed: October 4, 1991
    Date of Patent: December 29, 1992
    Assignee: Burroughs Wellcome Co.
    Inventors: Joel Van Tuttle, Thomas A. Krenitsky
  • 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
    Patent number: 5157114
    Abstract: The present invention relates to a 3'-substituted pyrimidine nucleoside and its use in medical therapy, particularly in the treatment of HIV infections. Also provided are pharmaceutical formulations.
    Type: Grant
    Filed: August 17, 1989
    Date of Patent: October 20, 1992
    Assignee: Burroughs Wellcome Co.
    Inventors: Saad G. Rahim, Thomas A. Krenitsky
  • Therapeutic nucleosides
    Patent number: 5071983
    Abstract: This invention relates to certain derivatives of 2', 3'-dideoxycytidine and their use in medical therapy particularly in the treatment of HIV infections. Also provided are pharmaceutical formulations and processes for the manufacture of the compounds according to the invention.
    Type: Grant
    Filed: October 6, 1989
    Date of Patent: December 10, 1991
    Assignee: Burroughs Wellcome Co.
    Inventors: George W. Koszalka, Thomas A. Krenitsky
  • Antiviral compounds
    Patent number: 5070078
    Abstract: 2',3'-Dideoxy-3'-fluoro pyrimidine nucleosides particularly 2',3'-dideoxy-3'-fluorothymidine have been found to have particularly potent activity against adenovirus infections especially those caused by adenoviruses of serotype 8. Such compounds are preferably presented in pharmaceutical formulations adapted for ophthalmic administration.
    Type: Grant
    Filed: August 19, 1988
    Date of Patent: December 3, 1991
    Assignee: Burroughs Wellcome Co.
    Inventors: John W. T. Selway, Lowrie M. Beacham, III, Susan M. Daluge, Joel Van Tuttle, Thomas A. Krenitsky
  • 2-amino-6-(cyclopropylamino)purine-9-.beta.-D-2',3'-dideo xyribofuranoside and its pharmaceutically acceptable salts
    Patent number: 5068320
    Abstract: This invention relates to certain 6-substituted 2',3'-dideoxypurine nucleosides and derivatives thereof. The compounds are useful as antivirals.
    Type: Grant
    Filed: October 6, 1989
    Date of Patent: November 26, 1991
    Assignee: Burroughs Wellcome Co.
    Inventors: George W. Koszalka, Charlene L. Burns, Thomas A. Krenitsky, Janet L. Rideout