Abstract: A surgical instrument that comprises a surgical end effector, a handle that is connected to the surgical end effector and has a controller, and an interchangeable part removably connected to the surgical end effector and having an encryption device in electrical communication with the controller. The encryption device is programmed to authenticate the interchangeable part when the interchangeable part is at the surgical end effector.

Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.

Abstract: The invention relates to a seal for a large roller bearing for sealing a joint between two adjacent ring segments or ring parts of the roller bearing, wherein at least two mutually spaced apart sealing limbs of a rubber elastic and/or yielding sealing material for sealing insertion into grooves that are formed at both sides of the joint in ring segments or ring parts that are adjacent to one another and a connection section connecting the sealing limbs and composed of a rubber elastic and/or yielding sealing material to span said joint.

Abstract: A clot removal system comprises a catheter, a vacuum source, and a controller. The catheter comprises a proximal end, a distal end, and controller operating parameters and defines a lumen configured to be filled with a liquid column having a proximal portion. The vacuum source is configured to supply vacuum. The controller is configured to carry out a control pattern of turning on and off the vacuum based upon the controller operating parameters and is configured to receive the controller operating parameters in an automatic response to the catheter being operatively connected to at least one of the vacuum source and the controller and, responsive to the connection, to carry out the control pattern to change a level of vacuum at the distal end of the catheter.

Abstract: Examples of electrical devices are described herein. In some examples, an electrical device includes a button disposed to protrude through a window of a faceplate. A gap is disposed between the button and the faceplate. The electrical device includes an ambient light guide disposed to (1) reside behind the gap and (2) collect ambient light to pass through the gap. The electrical device includes an ambient light sensor configured to sense the ambient light collected by the ambient light guide.

Abstract: Examples of molded buttons are described. In some examples, a button includes a transparent molded member. The button includes an opaque molded member attached to the transparent molded member. The opaque molded member includes a shield positioned along an edge of the transparent molded member. The shield is disposed to reduce backlight from exiting at the edge of the transparent molded member.

Abstract: Examples of electrical devices are described herein. In some examples, an electrical device includes a yoke plate including a first screw hole and a second screw hole. The electrical device includes a base including a third screw hole disposed to permit passage of a first screw through the third screw hole and the first screw hole. The electrical device includes a subplate including a fourth screw hole disposed to permit a second screw to attach the subplate to the yoke plate through the fourth screw hole and the second screw hole. The subplate includes a channel to expose the third screw hole to a facial side of the subplate.

Abstract: A method includes receiving, at a cloud storage system, a request to access a file from an external application on behalf of a first user account, determining, based on one or more access control lists (ACLs) associated with a shared folder, that the external application is not allowed to access the file on behalf of the first user account, and receiving, from a user device associated with the first user account, a message authorizing the external application to access the file on behalf of the first user account. The method further includes modifying the ACLs associated with the shared folder containing the file and a subfolder, and allowing the external application to access the file on behalf of the first user account based on the user information of the first user account and the application information of the external application in the modified ACLs.

Abstract: A method for operating a fuel cell system comprising a fuel cell assembly of a plurality of fuel cells configured to generate electrical power from a fuel flow and an oxidant flow to the plurality of fuel cells, the fuel cell assembly arranged in combination with a coolant storage module configured to supply the fuel cell assembly with a flow of coolant, the method performed when the temperature of the coolant in the coolant storage module is below a coolant temperature threshold and comprises; a first phase performed prior to activation of a coolant pump configured to deliver coolant from the coolant storage module to the fuel cell assembly and a second phase performed after activation of the coolant pump.

Abstract: A door system and a method of making a door system including a metal door, a metal door frame for the metal door, and one or more door frame seals. The metal door and the metal door frame each include a steel outer surface with a first metal layer in contact with and that encapsulates or covers the steel outer surface, and a second metal layer in contact with and that encapsulates or covers the first metal layer. The first metal layer is different from the second metal layer. The first metal layer can be optional. The door frame seals are located on the metal door frame and provide conductivity between the metal door and the metal door frame. The door system preferably has an acceptable sound transmission class rating and RF shielding properties.

Abstract: A downhole tool includes a tubular having an outer surface and an inner surface defining a flowbore having a longitudinal axis, and a backpressure valve arranged in the flowbore. The backpressure valve includes a flapper valve having a first side and an opposing second side pivotally mounted to the inner surface to selectively extend across the flowbore and a locking system mounted to the inner surface in the flowbore and snap-fittingly engageable with the flapper valve. The flapper valve is pivotable between a first position, wherein the flapper valve is free to pivot relative to the inner surface, and a second position, wherein the flapper valve is pivoted away from the flowbore and locked open by the locking system such that the first side forms part of the flowbore.

Abstract: A downhole tool includes a tubular having an outer surface and an inner surface defining a flowbore having a longitudinal axis, and a backpressure valve arranged in the flowbore. The backpressure valve includes a flapper valve including a first side and an opposing second side pivotally mounted to the inner surface to selectively extend across the flowbore, and a locking system mounted to the inner surface in the flowbore and selectively engageable with the flapper valve. The flapper valve is pivotable between a first position, wherein the flapper valve is free to pivot relative to the inner surface, and a second position, wherein the flapper valve is pivoted away from the flowbore and locked open by the locking system such that the first side forms part of the flowbore.

Abstract: Disclosed is a cooling module for use in a fuel cell system, the module includes a tank configured to receive a coolant therein, a coolant, a pump in fluid communication with the coolant in the tank and the fuel cell system, the pump being configured to transport the coolant to the fuel cell system, a heating element within the coolant in the tank, the heating element configured to heat the coolant, and at least one sensor in signal communication with a controller and in fluid communication with the tank. The sensor is configured to detect a change corresponding to the presence or absence of sufficient liquid coolant to initiate said pump, and the controller processes sensor data and is configured to actuate the pump.

Abstract: A downhole tool includes a tubular having an outer surface and an inner surface defining a flowbore having a longitudinal axis, and a backpressure valve cartridge arranged in the flowbore. The backpressure valve cartridge includes a valve seat and a flapper valve pivotally mounted relative to the valve seat. The backpressure valve cartridge is shiftable along the longitudinal axis to shift the flapper valve between a first position, wherein the flapper valve rests on the valve seat, and a second position, wherein the flapper valve is pivoted away from the valve seat.

Abstract: A system and method for recursive propagating application access control relate to managing third-party application access to content files and folders on a cloud storage system. The access control system may receive an access authorization indication to grant a third-party entity access to a parent folder containing a first file, and then modify an access control rule associated with the parent folder based on the access authorization indication. The modified access control rule is propagated to a child folder of the parent folder, and thus the third-party entity is granted access to a second file in the child folder based on the modified access control rule. The second file shares a common attribute with the first file, 1 and the modified access control rule specifies the common attribute.

Abstract: A downhole tool includes a tubular having an outer surface and an inner surface defining a flowbore having a longitudinal axis and a backpressure valve arranged in the flowbore. The backpressure valve includes a flapper valve including a hinge end, a cantilevered end, a first side and an opposing second side pivotally mounted to the inner surface at the hinge end to selectively extend across the flowbore, and a locking system mounted to the inner surface adjacent to the hinge end of the flapper valve in the flowbore. The flapper valve is pivotable between a first position, wherein the flapper valve is free to pivot relative to the inner surface between an open configuration and a closed configuration, and a second position, wherein the hinge end of the flapper valve activates the locking system to lock the flapper valve in the open configuration.

Abstract: A downhole tool includes a tubular having an outer surface and an inner surface defining a flowbore having a longitudinal axis, and a backpressure valve cartridge arranged in the flowbore. The backpressure valve cartridge includes a passage, a valve seat arranged in the passage, and a flapper valve pivotally mounted relative to the valve seat in the passage. The valve seat is shiftable within the backpressure valve cartridge along the longitudinal axis to shift the flapper valve between a first position, wherein the flapper valve is free to pivot relative to the valve seat, and a second position, wherein the flapper valve is pivoted away from the valve seat and maintained in an open configuration.

Abstract: A downhole tool includes a tubular having an outer surface and an inner surface defining a flowbore having a longitudinal axis. A backpressure valve is arranged in the flowbore. The backpressure valve includes a flapper valve including a first side and an opposing second side pivotally mounted to the inner surface to selectively extend across the flowbore and a locking system including a spring clip mounted to the inner surface. The flapper valve is pivotable between a first position, wherein the flapper valve is free to pivot relative to the inner surface, and a second position, wherein the flapper valve is pivoted away from the flowbore and locked open by the spring clip such that the first side forms part of the flowbore.

Abstract: A downhole tool includes a tubular having an outer surface and an inner surface defining a flowbore having a longitudinal axis, and a backpressure valve cartridge arranged in the flowbore. The backpressure valve cartridge includes a passage, a valve seat arranged in the passage, a flapper valve pivotally mounted relative to the valve seat in the passage, and a piston member configured to shift the flapper valve between a first position, wherein the flapper valve is free to pivot relative to the valve seat, and a second position, wherein the flapper valve is pivoted away from the valve seat and maintained in an open configuration.

Abstract: A downhole tool includes a tubular having an outer surface and an inner surface defining a flowbore having a longitudinal axis. A backpressure valve is arranged in the flowbore. The backpressure valve includes a flapper valve including a first side and an opposing second side pivotally mounted to the inner surface to selectively extend across the flowbore and a locking system including a spring clip mounted to the inner surface. The flapper valve is pivotable between a first position, wherein the flapper valve is free to pivot relative to the inner surface, and a second position, wherein the flapper valve is pivoted away from the flowbore and locked open by the spring clip such that the first side forms part of the flowbore.