Patents by Inventor Thomas A. Patterson

Thomas A. Patterson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and microorganisms for production of panto-compounds
    Patent number: 8232081
    Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzymeA biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ?-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX, as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured.
    Type: Grant
    Filed: November 8, 2004
    Date of Patent: July 31, 2012
    Assignee: BASF SE
    Inventors: R. Rogers Yocum, Thomas A. Patterson, Theron Hermann, Janice G. Pero
  • Microorganisms with a reactivation system for cob(I)alamin-dependent methionine synthase
    Patent number: 8163532
    Abstract: The present invention relates to microorganisms and methods for producing methionine by reactivation of the MetH enzyme.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: April 24, 2012
    Assignee: Evonik Degussa GmbH
    Inventors: Oskar Zelder, Hartwig Schröder, Corinna Klopprogge, Andrea Herold, Stefan Haefner, R. Rogers Yocum, Thomas A. Patterson, Mark Williams
  • Microorganism and process for the preparation of L-methionine
    Patent number: 8148117
    Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.
    Type: Grant
    Filed: October 23, 2006
    Date of Patent: April 3, 2012
    Assignee: Evonik Degussa GmbH
    Inventors: Oskar Zelder, Andrea Herold, Corinna Klopprogge, Hartwig Schröder, Stefan Haefner, Elmar Heinzle, Christoph Wittmann, Jens Kroemer, Janice G. Pero, R. Rogers Yocum, Thomas A. Patterson, Mark Williams, Theron Herman
  • Microorganisms and processes for enhanced production of pantothenate
    Patent number: 7989187
    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: August 2, 2011
    Assignee: BASF SE
    Inventors: Rogers R. Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
  • Microorganisms and assays for the identification of antibiotics
    Patent number: 7858335
    Abstract: The present invention features methods for the identification of compounds and compositions useful as antibiotics and antibacterial agents. In particular, the invention features methods for the identification of modulators of a previously unidentified target protein, termed CoaX. High-throughput assay systems are featured as well as assay kits for the identification of CoaX modulators. Also featured are coaX nucleic acid molecules and purified CoaX proteins, as well as recombinant vectors and microorganisms including the gene, coaX.
    Type: Grant
    Filed: February 22, 2007
    Date of Patent: December 28, 2010
    Assignee: OmniGene Bioproducts, Inc.
    Inventors: R. Rogers Yocum, Thomas A. Patterson
  • Microorganisms with Deregulated Vitamin B12 System
    Publication number: 20100047881
    Abstract: The present invention relates to microorganisms with improved efficiency of vitamin B12 utilization.
    Type: Application
    Filed: June 9, 2008
    Publication date: February 25, 2010
    Inventors: Oskar Zelder, Hartwig Schröder, Corinna Klopprogge, Andrea Herold, Stefan Haefner, Thomas A. Patterson
  • Coryneform Bacteria with Formate-THF-Synthetase and/or Glycine Cleavage Activity
    Publication number: 20100003727
    Abstract: The present invention relates to microorganisms, in particular C. glutamicum in which the formation of N5,N10-methylene-THF is increased. The present invention also relates to the use of such microorganisms for producing methionine.
    Type: Application
    Filed: February 14, 2008
    Publication date: January 7, 2010
    Inventors: Oskar Zelder, Hartwig Schröder, Corinna Klopprogge, Andrea Herold, Stefan Haefner, Thomas A. Patterson, R. Rogers Yocum, Janice G. Pero
  • Microorganisms with a Reactivation System for cob(I)Alamin-Dependent Methionine Synthase
    Publication number: 20090311756
    Abstract: The present invention relates to microorganisms and methods for producing methionine by reactivation of the MetH enzyme.
    Type: Application
    Filed: May 27, 2009
    Publication date: December 17, 2009
    Inventors: Oskar Zelder, Hartwig Schröder, Corinna Klopprogge, Andrea Herold, Stefan Haefner, R. Rogers Yocum, Thomas A. Patterson, Mark Williams
  • MICROORGANISM AND PROCESS FOR THE PREPARATION OF L-METHIONINE
    Publication number: 20090298137
    Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.
    Type: Application
    Filed: October 23, 2006
    Publication date: December 3, 2009
    Applicant: BASF AG
    Inventors: Oskar Zelder, Andreas Herold, Corinna Klopprogge, Hartwig Schröder, Stefan Haefner, Elmar Heinzle, Christoph Wittmann, Jens Kroemer, Janice G. Pero, R. Rogers Yocum, Thomas A. Patterson, Mark Williams, Theron Herman
  • Methionine producing recombinant microorganisms
    Publication number: 20090298136
    Abstract: This invention relates to methionine producing recombinant microorganisms. Specifically, this invention relates to recombinant strains of Corynebacterium that produce increased levels of methionine compared to their wild-type counterparts and further to methods of generating such microorganisms.
    Type: Application
    Filed: July 18, 2006
    Publication date: December 3, 2009
    Applicant: BASF AG
    Inventors: Oskar Zelder, Stefan Haefner, Corinna Klopprogge, Hartwig Schroder, Andrea Herold, Thomas A. Patterson, Theron Hermann, R. Rogers Yocum, Mark K. William, Janice G. Pero
  • Microorganisms With Increased Efficiency for Methionine Synthesis
    Publication number: 20090191610
    Abstract: The present invention relates to methods for the production of microorganisms with increased efficiency for methionine synthesis, microorganisms with increased efficiency for methionine synthesis, and methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis.
    Type: Application
    Filed: August 18, 2006
    Publication date: July 30, 2009
    Applicant: Evonik Degussa GmbH
    Inventors: Oskar Zelder, Andrea Herold, Corinna Klopprogge, Hartwig Schroder, Stefan Haefner, Elmar Heinzle, Christoph Wittmann, Jens Kroemer, Janice G. Pero, R. Rogers Yocum, Thomas A. Patterson, Mark Williams, Theron Herman
  • Microorganisms and processes for enhanced production of pantothenate
    Publication number: 20080166777
    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Application
    Filed: July 16, 2007
    Publication date: July 10, 2008
    Applicant: BASF Aktiengesellschaft
    Inventors: R. Rogers Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
  • Microorganisms and assays for the identification of antibiotics
    Publication number: 20080160551
    Abstract: The present invention features methods for the identification of compounds and compositions useful as antibiotics and antibacterial agents. In particular, the invention features methods for the identification of modulators of a previously unidentified target protein, termed CoaX. High-throughput assay systems are featured as well as assay kits for the identification of CoaX modulators. Also featured are coaX nucleic acid molecules and purified CoaX proteins, as well as recombinant vectors and microorganisms including the gene, coaX.
    Type: Application
    Filed: February 22, 2007
    Publication date: July 3, 2008
    Applicant: OmniGene Bioproducts, Inc.
    Inventors: R. Rogers Yocum, Thomas A. Patterson
  • Microorganisms and processes for enhanced production of pantothenate
    Patent number: 7291489
    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: November 6, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: R. Rogers Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
  • Microorganisms and processes for enhanced production of pantothenate
    Patent number: 7244593
    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: July 17, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: R. Roger Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
  • Processes for enhanced production of pantothenate
    Patent number: 7220561
    Abstract: The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features methods for reducing byproduct formation and increasing yields and purity of desired product. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Grant
    Filed: January 19, 2002
    Date of Patent: May 22, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Theron Hermann, Thomas A. Patterson, Janice G. Pero, R. Roger Yocum, Kai-Uwe Baldenius, Christine Beck
  • Microorganisms and assays for the identification of antibiotics
    Patent number: 6830898
    Abstract: The present invention features methods for the identification of compounds and compositions useful as antibiotics and antibacterial agents. In particular, the invention features methods for the identification of modulators of a previously unidentified target protein, termed CoaX. High-throughput assay systems are featured as well as assay kits for the identification of CoaX modulators. Also featured are coaX nucleic acid molecules and purified CoaX proteins, as well as recombinant vectors and microorganisms including the gene, coaX.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: December 14, 2004
    Assignee: OmniGene Bioproducts, Inc.
    Inventors: R. Rogers Yocum, Thomas A. Patterson
  • Microorganisms and processes for enhanced production of pantothenate
    Publication number: 20040146996
    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Application
    Filed: July 3, 2003
    Publication date: July 29, 2004
    Inventors: R. Rogers Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
  • Microorganisms and processes for enhanced production of pantothenate
    Publication number: 20040091979
    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Application
    Filed: July 18, 2003
    Publication date: May 13, 2004
    Inventors: Rogers R. Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
  • Processes for enhanced production of pantothenate
    Publication number: 20040086982
    Abstract: The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features methods for reducing byproduct formation and increasing yields and purity of desired product. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Application
    Filed: July 18, 2003
    Publication date: May 6, 2004
    Inventors: Theron Hermann, Thomas A. Patterson, Janice G. Pero, R. Rogers Yocum, Kai-Uwe Baldenius, Christine Beck