Abstract: Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.

Abstract: A mattress includes one or more sensors. The sensor(s) may be positioned on a sleep surface of the mattress; for example, at locations where an individual's thorax and/or legs would be positioned when the individual assumes a sleeping position on the sleep surface. The sensor(s) may be positioned adjacent to an edge of the mattress, on the sleep surface or on the edge. A processor may be associated with the sensor(s) of the mattress. The processor may process signals received from the sensor(s) to provide information about the mattress, an individual on the mattress, and/or an environment in which the mattress is located.

Abstract: A method of generating customizable goal representation is disclosed. A request from a user to view a goal representation is received. A flexible goal ontology is accessed that comprises one or more goal entities, one or more goal relationships between the goal entities, or one or more goal properties, the one or more goal properties including one or more metadata attributes relating to the one or more goal entities. A set of mapping rules is obtained that defines mappings between one or more goals. The set of mapping rules is evaluated to assemble a customized goal representation tailored to the user. The customized goal representation is updated based on a revaluation of the mapping rules affected by changes to the one or more goal entities, the one or more goal relationships, or the one or more properties.

Abstract: A method of implementing administrative services for a compensation platform is disclosed. One or more interactive compensation representation views are generated based on an evaluation of mapping rules against a flexible ontology and current data state, the flexible ontology comprising customizable compensation components, relationships, and properties. One or more compensation representation views are dynamically updated in real-time in response to changes in compensation data, user context, or access permissions without requiring manual regeneration of the one or more compensation representations. The one or more interactive compensation representation views include a user interface element displayed in response to a user selection of compensation data, wherein the user interface element provides direct access to compensation information relevant to the selected compensation data without requiring a change to another screen or another user context.

Abstract: An apparatus, and a method, performed by one or more processors are disclosed. The method receives a build request associated with performing an external data processing task on a first data set, the first data set being stored in memory associated with a data processing platform to be performed at a system external to the data processing platform. The method generates a task identifier for the data processing task, and provides, in association with the task identifier, the first data set to an agent associated with the external system with an indication of the data processing task, the agent being arranged to cause performance of the task at the external system, to receive a second data set resulting from performance of the task, and to provide the second data set and associated metadata indicative of the transformation. The method receives the second data set and metadata from the agent associated with the external system and stores the second data set and associated metadata.

Abstract: An apparatus, and a method, performed by one or more processors are disclosed. The method receives a build request associated with performing an external data processing task on a first data set, the first data set being stored in memory associated with a data processing platform to be performed at a system external to the data processing platform. The method generates a task identifier for the data processing task, and providing, in association with the task identifier, the first data set to an agent associated with the external system with an indication of the data processing task, the agent being arranged to cause performance of the task at the external system, to receive a second data set resulting from performance of the task, and to provide the second data set and associated metadata indicative of the transformation. The method receives the second data set and metadata from the agent associated with the external system and stores the second data set and associated metadata.

Abstract: Systems, computer program products, and computer-implemented methods for visualizing and interacting with a plurality of models that collectively represent a real-world system depicted in a graphical user interface. The system described herein may generate an interactive graphical user interface with multiple modes and a plurality of panels associated with the plurality of models. These panels and modes lay the framework for how a user can properly visualize and analyze the models at a particular point in time or over a period of time. The systems, computer program products, and computer-implemented methods may thus, according to various embodiments, enable a plurality of models that collectively represent a real-world system be interacted with and visualized by a graphical user interface.

Abstract: Example embodiments describe a method performed by one or more processors. The method may comprise sending over a network, to a software component installed at a remote data source, a request to download data stored at, or in association with, the remote data source, the software component being configured to access performance data at said remote data source. In response to sending the request, the method may comprise receiving from the software component at least an indication of the performance data accessed by said software component, determining whether to proceed with the data download request or to modify the data download request based on the received performance data.

Abstract: Systems, computer program products, and computer-implemented methods for visualizing and interacting with a plurality of models that collectively represent a real-world system depicted in a graphical user interface. The system described herein may generate an interactive graphical user interface with multiple modes and a plurality of panels associated with the plurality of models. These panels and modes lay the framework for how a user can properly visualize and analyze the models at a particular point in time or over a period of time. The systems, computer program products, and computer-implemented methods may thus, according to various embodiments, enable a plurality of models that collectively represent a real-world system be interacted with and visualized by a graphical user interface.

Abstract: An impact resistant textile-supported garment, or component thereof, comprises a fabric layer, and (i) at least five non-interconnected impact resistant polyurethane segments upon an outer surface of the fabric layer, wherein at least two of the non-interconnected impact resistant polyurethane segments has a depth of at least 3 mm, preferably at least 4 mm, and wherein at least five of the plurality of non-interconnected segments have dimensions smaller than 1.75 cm × 1 cm × 1 cm; or (ii) at least one non-interconnected impact resistant polyurethane segment, wherein the at least one segment has a depth of at least 3 mm at its deepest part, and wherein the at least one segment is a hollow segment comprising one or more regions defined by an outer polyurethane perimeter, surrounding a region of fabric that is not covered by polyurethane.

Abstract: Example embodiments describe a method performed by one or more processors. The method may comprise sending over a network, to a software component installed at a remote data source, a request to download data stored at, or in association with, the remote data source, the software component being configured to access performance data at said remote data source. In response to sending the request, the method may comprise receiving from the software component at least an indication of the performance data accessed by said software component, determining whether to proceed with the data download request or to modify the data download request based on the received performance data.

Abstract: An apparatus, and a method, performed by one or more processors are disclosed. The method may comprise receiving a build request associated with performing an external data processing task on a first data set, the first data set being stored in memory associated with a data processing platform to be performed at a system external to the data processing platform. The method may also comprise generating a task identifier for the data processing task, and providing, in association with the task identifier, the first data set to an agent associated with the external system with an indication of the data processing task, the agent being arranged to cause performance of the task at the external system, to receive a second data set resulting from performance of the task, and to provide the second data set and associated metadata indicative of the transformation.

Abstract: An apparatus, and a method, performed by one or more processors are disclosed. The method may comprise receiving a build request associated with performing an external data processing task on a first data set, the first data set being stored in memory associated with a data processing platform to be performed at a system external to the data processing platform. The method may also comprise generating a task identifier for the data processing task, and providing, in association with the task identifier, the first data set to an agent associated with the external system with an indication of the data processing task, the agent being arranged to cause performance of the task at the external system, to receive a second data set resulting from performance of the task, and to provide the second data set and associated metadata indicative of the transformation.

Abstract: Systems, computer program products, and computer-implemented methods for visualizing and interacting with a plurality of models that collectively represent a real-world system depicted in a graphical user interface. The system described herein may generate an interactive graphical user interface with multiple modes and a plurality of panels associated with the plurality of models. These panels and modes lay the framework for how a user can properly visualize and analyze the models at a particular point in time or over a period of time. The systems, computer program products, and computer-implemented methods may thus, according to various embodiments, enable a plurality of models that collectively represent a real-world system be interacted with and visualized by a graphical user interface.

Abstract: A system comprising a computer-readable storage medium storing at least one program and a method for determining, tracking, and anticipating risk in a manufacturing facility are presented. In example embodiments, the method includes generating a risk data model for the manufacturing facility based on correlations between historical staffing conditions of the manufacturing facility and deviations from existing manufacturing procedures. The method further includes receiving projected operational data that includes information related to anticipated future staffing conditions of the manufacturing facility. The method further includes calculating a risk score based on the projected operational data using the risk data model. The method further includes causing presentation of a user interface that includes a display of the risk score.

Abstract: Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.

Abstract: Example embodiments describe a method performed by one or more processors. The method may comprise sending over a network, to a software component installed at a remote data source, a request to download data stored at, or in association with, the remote data source, the software component being configured to access performance data at said remote data source. In response to sending the request, the method may comprise receiving from the software component at least an indication of the performance data accessed by said software component, determining whether to proceed with the data download request or to modify the data download request based on the received performance data.

Abstract: An apparatus, and a method, performed by one or more processors are disclosed. The method may comprise receiving a build request associated with performing an external data processing task on a first data set, the first data set being stored in memory associated with a data processing platform to be performed at a system external to the data processing platform. The method may also comprise generating a task identifier for the data processing task, and providing, in association with the task identifier, the first data set to an agent associated with the external system with an indication of the data processing task, the agent being arranged to cause performance of the task at the external system, to receive a second data set resulting from performance of the task, and to provide the second data set and associated metadata indicative of the transformation.