Abstract: A method of attenuating annular pressure buildup within a wellbore. The method includes accessing a wellbore, with the wellbore having an annulus disposed between first and second strings of casing. The method also includes placing a column of cement around the second string of casing generally below the first string of casing. The method further includes pumping a fluid mixture into the annulus, forming a fluid column. The fluid mixture comprises a carrier fluid, and a plurality of compressible particles dispersed in the carrier fluid. Each of the compressible particles is fabricated to partially collapse in response to thermal expansion of the fluid mixture. The method also includes placing a wellhead over the wellbore, thereby forming a trapped annulus in the wellbore. The method additionally includes at least partially sealing the annular region along at least one depth above the column of cement to inhibit vertical migration of the compressible particles.

Abstract: A collection of compressible particles. The compressible particles are intended to be used for attenuating pressure build-up within a confined volume such as a trapped annulus in a wellbore. Each of the compressible particles is fabricated to collapse in response to fluid pressure within the confined volume, and comprises carbon. Particularly, each of the particles comprises a plurality of peripheral openings, permitting an ingress of wellbore fluids in response to an increase in pressure within a trapped annulus. The collection of compressible particles together has a reversible volumetric expansion/contraction of ?10% and up to 25% at pressures up to 10,000 psi. A method of attenuating annular pressure buildup within a wellbore using the collection of compressible particles is also provided.

Abstract: A raster unit is configured to generate different sample patterns for adjacent pixels within a given frame. In addition, the raster unit may adjust the sample patterns between frames. The raster unit includes an index unit that selects a sample pattern table for use with a current frame. For a given pixel, the index unit extracts a sample pattern from the selected sample pattern table. The extracted sample pattern is used to generate coverage information for the pixel. The coverage information for all pixels is then used to generate an image. The resultant image may then be filtered to reduce or remove artifacts induced by the changing of sample locations.

Abstract: The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a hyperproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.

Abstract: A method is provided for operating a frequency converter, which is designed to drive a three-phase motor, wherein the frequency converter has three half-bridges each having at least two switches. The method includes the following steps: generating three phase voltages for the three-phase motor by a pulse width modulation, wherein, for the pulse width modulation, various switching patterns of the switches are activated, wherein specific star point voltages ensue for various groups of switching patterns; and in at least one operating state of the frequency converter, within a respective period of the pulse width modulation, activating only those switching patterns in which an identical star point voltage ensues.

Abstract: Methods and compositions relating to isolated mitochondria are disclosed. For example, cells, tissues, or organs can be treated with isolated mitochondria, such as porcine mitochondria, to improve mitochondrial function in the cell, tissue, or organ. The improvements to mitochondrial function include increased oxygen consumption and increased ATP synthesis. Such methods and compositions are useful for cell therapy; organ and tissue transplantation; organ and tissue engineering; and cold storage or shipment of harvested organs, tissues, and cells.

Abstract: The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a hyperproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.

Abstract: An automated bioreactor system for decellularizing an organ includes a main chamber for containing the organ. The system further includes a reagent chamber containing a liquid phase reagent. A reagent conduit delivers the liquid phase reagent to the main chamber, and a perfusion conduit delivers the reagent from the reagent outlet in the main chamber into the organ. A perfusion pump drives the flow of the reagent. A perfusion pressure sensor detects a pressure of the flowing reagent. A control system controls the perfusion pump to drive the flow of the reagent based on a received input representative of a desired pressure and a received input of the detected pressure. The control system may automatically perform all of the steps of a decellularization protocol based on sensor input. An automated waste decontamination system may also be provided.

Abstract: An electrical connector including first and second connector parts configured for mating together, and with one of the connector parts having a sensory feedback member that moves between an extended position and a retracted position as a result of magnetic interaction with an actuation element in the other connector part during mating of the connector parts. The movement of the sensory feedback member causes a sensory feedback indication, such as an audible sound or a tactile vibration.

Abstract: The present invention relates to compositions comprising a decellularized tissue. The present invention also provides an engineered three dimensional lung tissue exhibiting characteristics of a natural lung tissue. The engineered tissue is useful for the study of lung developmental biology and pathology as well as drug discovery.

Abstract: Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.

Abstract: A raster unit is configured to generate different sample patterns for adjacent pixels within a given frame. In addition, the raster unit may adjust the sample patterns between frames. The raster unit includes an index unit that selects a sample pattern table for use with a current frame. For a given pixel, the index unit extracts a sample pattern from the selected sample pattern table. The extracted sample pattern is used to generate coverage information for the pixel. The coverage information for all pixels is then used to generate an image. The resultant image may then be filtered to reduce or remove artifacts induced by the changing of sample locations.

Abstract: The present invention relates to compositions comprising a decellularized tissue. The present invention also provides an engineered three dimensional lung tissue exhibiting characteristics of a natural lung tissue. The engineered tissue is useful for the study of lung developmental biology and pathology as well as drug discovery.

Abstract: A portable electrical power unit includes a housing defining an interior region that receives a power source, such as a rechargeable battery or capacitor, and one or more electrical connectors that are accessible at or through outer surfaces of the housing. The housing includes a substantially flat base for resting atop generally horizontal surface, and may include a power switch for selectively energizing the outlets. Optionally, a charging indicator provides a visual indication of the current capacity or charge level of the onboard power source. The power unit may receive or convey electrical power via direct-contact electrical terminals or via inductive power transmission, and may include additional features such as a location-detecting circuit operable to detect and generate a signal in the event that the power unit is moved out of a predefined area.

Abstract: The application is directed to a method for treating or preventing vasculopathy comprising administrating to a subject in need thereof a pharmaceutical composition comprising mesenchymal precursor cells (MPCs) and a prostacyclin. Also provided a method for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.

Abstract: An electrical connector including first and second connector parts configured for mating together, and with one of the connector parts having a sensory feedback member that moves between an extended position and a retracted position as a result of magnetic interaction with an actuation element in the other connector part during mating of the connector parts. The movement of the sensory feedback member causes a sensory feedback indication, such as an audible sound or a tactile vibration.

Abstract: A raster unit is configured to generate different sample patterns for adjacent pixels within a given frame. In addition, the raster unit may adjust the sample patterns between frames. The raster unit includes an index unit that selects a sample pattern table for use with a current frame. For a given pixel, the index unit extracts a sample pattern from the selected sample pattern table. The extracted sample pattern is used to generate coverage information for the pixel. The coverage information for all pixels is then used to generate an image. The resultant image may then be filtered to reduce or remove artifacts induced by the changing of sample locations.

Abstract: A raster unit is configured to generate different sample patterns for adjacent pixels within a given frame. In addition, the raster unit may adjust the sample patterns between frames. The raster unit includes an index unit that selects a sample pattern table for use with a current frame. For a given pixel, the index unit extracts a sample pattern from the selected sample pattern table. The extracted sample pattern is used to generate coverage information for the pixel. The coverage information for all pixels is then used to generate an image. The resultant image may then be filtered to reduce or remove artifacts induced by the changing of sample locations.

Abstract: The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a hyperproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.