Abstract: The present invention relates to an antibody or an antigen binding fragment thereof that specifically binds to ?-1,6-core-fucosylated prostate specific antigen (PSA) and partial sequences thereof comprising the ?-1,6-core-fucose residue. The antibodies and antigen binding fragments significantly discriminate between core-fucosylated PSA or core-fucosylated PSA partial sequences and other glycosylated PSA species and partial sequences thereof lacking the core-fucose residue, including aglycosylated PSA, as well as core-fucosylated glycan in other contexts. The present invention further relates to nucleic acid molecules encoding the light chain variable region or the heavy chain variable region of the antibody of the invention, as well as vectors comprising said nucleic acid molecules.

Abstract: A bolt repair platform includes a frame and a tool module. The tool module includes a tool having a first end configured to rotationally engage a bolt. The tool module also includes an actuator disposed between the tool and the frame so that actuation of the actuator moves the tool with respect to the frame. The frame is removably disposed on the structure, and the tool is movable with respect to the frame, so that, at each of a plurality of positions, the second end of the tool is capable of engagement with a respective bolt disposed in an internal support structure of a nuclear reactor vessel.

Abstract: A bolt repair platform includes a frame and a tool module. The tool module includes a tool having a first end configured to rotationally engage a bolt. The tool module also includes an actuator disposed between the tool and the frame so that actuation of the actuator moves the tool with respect to the frame. The frame is removably disposed on the structure, and the tool is movable with respect to the frame, so that, at each of a plurality of positions, the second end of the tool is capable of engagement with a respective bolt disposed in an internal support structure of a nuclear reactor vessel.

Abstract: A protection circuit for protecting a switch from a fault includes a first sensing circuit and a second sensing circuit. The first sensing circuit senses a low-side load current through a switch that includes a first terminal, a second terminal and a control terminal. The first terminal is connected to a low-side of the load and the second terminal is connected to ground. The switch provides a conductive path between the first and second terminals responsive to a control signal provided on the control terminal. The first sensing circuit acts to reduce a magnitude of the control signal to limit the low-side load current, carried by the switch, when the low-side load current exceeds a first predetermined value. The second sensing circuit senses a voltage at the low-side of the load and interrupts the low-side load current, when the voltage at the low-side of the load exceeds a second predetermined value.