Patents by Inventor Thomas A. Rano

Thomas A. Rano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted piperidinyl-carboxamide derivatives useful as SCD 1 inhibitors
    Patent number: 9238658
    Abstract: The present invention is directed to novel piperidinyl-carboxamide derivatives, pharmaceutical compositions containing them and their use as inhibitors of SCD1, useful in the treatment of obesity, type-II diabetes and other related metabolic disorders.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: January 19, 2016
    Assignee: Janssen Pharmaceutica NV
    Inventors: Shyh-Ming Yang, Gee-Hong Kuo, Micheal D. Gaul, Thomas A. Rano
  • Substituted piperidinyl-pyridazinyl derivatives useful as SCD 1 inhibitors
    Patent number: 9102669
    Abstract: The present invention is directed to novel piperidinyl-pyridazinyl derivatives, pharmaceutical compositions containing them and their use as inhibitors of SCD1, useful in the treatment of obesity, type-II diabetes and other related metabolic disorders.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: August 11, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Shyh-Ming Yang, Gee-Hong Kuo, Micheal D. Gaul, Thomas A. Rano
  • SUBSTITUTED PIPERIDINYL-PYRIDAZINYL DERIVATIVES USEFUL AS SCD 1 INHIBITORS
    Publication number: 20140371220
    Abstract: The present invention is directed to novel piperidinyl-pyridazinyl derivatives, pharmaceutical compositions containing them and their use as inhibitors of SCD1, useful in the treatment of obesity, type-II diabetes and other related metabolic disorders.
    Type: Application
    Filed: December 5, 2012
    Publication date: December 18, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: Shyh-Ming Yang, Gee-Hong Kuo, Micheal D. Gaul, Thomas A. Rano
  • SUBSTITUTED PIPERIDINYL-CARBOXAMIDE DERIVATIVES USEFUL AS SCD 1 INHIBITORS
    Publication number: 20140364393
    Abstract: The present invention is directed to novel piperidinyl-carboxamide derivatives, pharmaceutical compositions containing them and their use as inhibitors of SCD1, useful in the treatment of obesity, type-II diabetes and other related metabolic disorders.
    Type: Application
    Filed: December 5, 2012
    Publication date: December 11, 2014
    Inventors: Shyh-Ming Yang, Gee-Hong Kuo, Micheal D. Gaul, Thomas A. Rano
  • 3,4-dihydro-2H-benzo[1,4]oxazine and thiazine derivatives as CETP inhibitors
    Patent number: 8012963
    Abstract: The invention is directed to compounds of Formula (I) described herein useful as CETP inhibitors, compositions containing them, and methods of using them.
    Type: Grant
    Filed: May 18, 2010
    Date of Patent: September 6, 2011
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Gee-Hong Kuo, Thomas Rano, Aihua Wang, Catherine Prouty, Keith T. Demarest, Patricia Pelton
  • 1,2,3,4-tetrahydro-quinoline derivatives as CETP inhibitors
    Patent number: 7928238
    Abstract: The invention is directed to compounds of Formula (I) described herein useful as CETP inhibitors, compositions containing them, and methods of using them.
    Type: Grant
    Filed: May 10, 2007
    Date of Patent: April 19, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Thomas Rano, Gee-Hong Kuo, Ellen Sieber-McMaster, Keith T. Demarest, Patricia Pelton, Aihua Wang
  • 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE AND THIAZINE DERIVATIVES AS CETP INHIBITORS
    Publication number: 20100227857
    Abstract: The invention is directed to compounds of Formula (I) described herein useful as CETP inhibitors, compositions containing them, and methods of using them.
    Type: Application
    Filed: May 18, 2010
    Publication date: September 9, 2010
    Inventors: Gee-Hong Kuo, Thomas Rano, Aihua Wang, Catherine Prouty, Keith T. Demarest, Patricia Pelton
  • 3,4-dihydro-2h-benzo[1,4]oxazine and thiazine derivatives as CETP inhibitors
    Patent number: 7749995
    Abstract: The invention is directed to compounds of Formula (I) described herein useful as CETP inhibitors, compositions containing them, and methods of using them.
    Type: Grant
    Filed: May 10, 2007
    Date of Patent: July 6, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Gee-Hong Kuo, Aihua Wang, Thomas Rano, Catherine Prouty, Keith T. Demarest, Patricia Pelton
  • 1,2,3,4-TETRAHYDRO-QUINOLINE DERIVATIVES AS CETP INHIBITORS
    Publication number: 20070265304
    Abstract: The invention is directed to compounds of Formula (I) described herein useful as CETP inhibitors, compositions containing them, and methods of using them.
    Type: Application
    Filed: May 10, 2007
    Publication date: November 15, 2007
    Inventors: Thomas Rano, Gee-Hong Kuo, Ellen Sieber-McMaster, Keith T. Demarest, Patricia Pelton, Aihua Wang
  • 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE AND THIAZINE DERIVATIVES AS CETP INHIBITORS
    Publication number: 20070265252
    Abstract: The invention is directed to compounds of Formula (I) described herein useful as CETP inhibitors, compositions containing them, and methods of using them.
    Type: Application
    Filed: May 10, 2007
    Publication date: November 15, 2007
    Inventors: Gee-Hong Kuo, Aihua Wang, Thomas Rano, Catherine Prouty, Keith T. Demarest, Patricia Pelton
  • Gamma-hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamides and uses thereof
    Patent number: 6642237
    Abstract: &ggr;-Hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamide compounds are inhibitors of HIV protease and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. These compounds are effective against HIV viral mutants which are resistant to HIV protease inhibitors currently used for treating AIDS and HIV infection.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: November 4, 2003
    Assignee: Merck & Co., Inc.
    Inventors: James R. Tata, Kevin T. Chapman, Joseph Leslie Duffy, Nancy J. Kevin, Yuan Cheng, Thomas A. Rano, Fengqi Zhang, Tracy Huening, Brian Anthony Kirk, Zhijian Lu, Subharekha Raghavan, Fred J. Fleitz, Daniel E. Petrillo, Joseph D. Armstrong, III, Richard J. Varsolona, David Askin, R. Scott Hoerrner, Robert Purick
  • Alpha-hydroxy-gamma-[[(carbocyclic-or heterocyclic-substituted)amino]carbonyl]alkanamide derivatives and uses thereof
    Patent number: 6589962
    Abstract: Certain &agr;-hydroxy-&ggr;-[[(carbocyclic- or heterocyclic-substituted)amino]carbonyl]alkanamide derivatives are described as inhibitors of HIV protease and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. These compounds are effective against HIV viral mutants which are resistant to HIV protease inhibitors currently used for treating AIDS and HIV infection.
    Type: Grant
    Filed: April 16, 2002
    Date of Patent: July 8, 2003
    Assignee: Merck & Co., Inc.
    Inventors: James R Tata, Zhijian Lu, Subharekha Raghavan, Tracy T. Huening, Thomas A. Rano, Mark G. Charest
  • 2-phenanthridinyl carbaphenem antibacterial agent
    Patent number: 5336674
    Abstract: The present invention relates to antibacterial agents of the carbapenem class, in which the 2-position sidechain is characterized by a phenanthridine moiety typically having a substituent attached to the nitrogen of the phenanthridine and substituted at other positions by various neutral substituents. When there is substitution on the nitrogen of the phenathridine moiety that nitrogen is a charged quaternary nitrogen.
    Type: Grant
    Filed: January 27, 1993
    Date of Patent: August 9, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Frank P. Dininno, Mark L. Greenlee, Thomas A. Rano, Wendy Lee
  • 2-phenanthridinyl carbapenem antibacterial agents
    Patent number: 5328904
    Abstract: The present invention relates to antibacterial agents of the carbapenem class, in which the 2-position sidechain is characterized by a phenanthridine moiety, substituted by various neutral substituents.
    Type: Grant
    Filed: January 27, 1993
    Date of Patent: July 12, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Frank P. DiNinno, Mark L. Greenlee, Thomas A. Rano, Wendy Lee
  • 2-benzocoumarinyl-carbapenems
    Patent number: 5216146
    Abstract: Carbapenems of the formula ##STR1## are useful intermediates to antibacterial agents.
    Type: Grant
    Filed: May 24, 1991
    Date of Patent: June 1, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Frank DiNinno, Mark L. Greenlee, Thomas A. Rano
  • 2-phenanthridonyl-carbapenems
    Patent number: 5214139
    Abstract: Carbapenems of the formula ##STR1## wherein: P' is a removable protecting group for hydroxy; andM is a removable protecting group for carboxy;are useful intermediates for carbapenem antibiotics.
    Type: Grant
    Filed: April 16, 1991
    Date of Patent: May 25, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Frank DiNinno, Thomas A. Rano, Mark L. Greenlee
  • 2-phenanthridonyl carbapenem intermediates
    Patent number: 5208328
    Abstract: Carbapenems of the formula ##STR1## wherein: P' is a removable protecting group for hydroxy; and M is a removable protecting group for carboxy; are useful intermediates for carbapenem antibiotics.
    Type: Grant
    Filed: April 16, 1991
    Date of Patent: May 4, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Frank DiNinno, Mark L. Greenlee, Thomas A. Rano
  • 2-benzocoumarinyl carbapenems
    Patent number: 5182384
    Abstract: Carbapenems of the formula ##STR1## are useful intermediates to antibacterial agents.
    Type: Grant
    Filed: May 24, 1991
    Date of Patent: January 26, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Frank DiNinno, Thomas A. Rano, Mark L. Greenlee
  • 2-benzocoumarinyl carbapenems
    Patent number: 5162314
    Abstract: Carbapenems of the formula ##STR1## with E as ##STR2## are useful antibacterial agents.
    Type: Grant
    Filed: May 24, 1991
    Date of Patent: November 10, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Frank DiNinno, Mark L. Greenlee, Thomas A. Rano
  • 2-phenanthridonyl carbapenems having cationizeable substituents
    Patent number: 5157033
    Abstract: Carbapenems of the formula ##STR1## are useful antibacterial agents.
    Type: Grant
    Filed: April 16, 1991
    Date of Patent: October 20, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Frank DiNinno, Mark L. Greenlee, Thomas A. Rano