Patents by Inventor Thomas A. Swann
Thomas A. Swann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230366858Abstract: Multidimensional liquid chromatography (MDLC) systems include valve configurations that enable a flow containing analytes in the eluent of a first dimension liquid chromatography system to be modulated such that the analytes can be captured in fluidic loops and subsequently provided to a second dimension liquid chromatography system. Optionally, a single detector is used for both first and second dimensions. In addition, the systems can enable dilution of the analytes and enable incompatible mobile phases and mobile phase flow rates to be used in the first and second dimensions.Type: ApplicationFiled: July 25, 2023Publication date: November 16, 2023Inventors: Michael O. Fogwill, Sylvain Gilles Cormier, Thomas Swann, Francis Patrick Tracey
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Patent number: 11747312Abstract: Multidimensional liquid chromatography (MDLC) systems include valve configurations that enable a flow containing analytes in the eluent of a first dimension liquid chromatography system to be modulated such that the analytes can be captured in fluidic loops and subsequently provided to a second dimension liquid chromatography system. Optionally, a single detector is used for both first and second dimensions. In addition, the systems can enable dilution of the analytes and enable incompatible mobile phases and mobile phase flow rates to be used in the first and second dimensions.Type: GrantFiled: May 4, 2021Date of Patent: September 5, 2023Assignee: Waters Technologies CorporationInventors: Michael O. Fogwill, Sylvain Gilles Cormier, Thomas Swann, Francis Patrick Tracey
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Publication number: 20230204478Abstract: In various aspects, the present disclosure pertains to methods of performing a sample enrichment procedure, which comprise: adding a sample fluid that comprises at least one phospholipid and at least one target analyte to a sorbent that comprises a hydrophobic component and a cation exchange component, thereby resulting in sorbent with bound phospholipid and bound target analyte; adding an aqueous solution comprising an acidic compound and a salt; adding an organic solution to the sorbent thereby desorbing at least a portion of the bound phospholipid from the sorbent; and adding an elution solution to the sorbent, thereby desorbing at least a portion of the bound target analyte from the sorbent and forming a solution of the target analyte in the elution solution. In other aspects, the present disclosure pertains to kits, which may be used in conjunction with such methods.Type: ApplicationFiled: February 9, 2023Publication date: June 29, 2023Applicant: Waters Technologies CorporationInventors: Bonnie A. Alden, Kenneth Berthelette, Jon Finch, Donna Osterman, Thomas Swann, Thomas H. Walter
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Patent number: 11604123Abstract: In various aspects, the present disclosure pertains to methods of performing a sample enrichment procedure, which comprise: adding a sample fluid that comprises at least one phospholipid and at least one target analyte to a sorbent that comprises a hydrophobic component and a cation exchange component, thereby resulting in sorbent with bound phospholipid and bound target analyte; adding an aqueous solution comprising an acidic compound and a salt; adding an organic solution to the sorbent thereby desorbing at least a portion of the bound phospholipid from the sorbent; and adding an elution solution to the sorbent, thereby desorbing at least a portion of the bound target analyte from the sorbent and forming a solution of the target analyte in the elution solution. In other aspects, the present disclosure pertains to kits, which may be used in conjunction with such methods.Type: GrantFiled: December 21, 2018Date of Patent: March 14, 2023Assignee: Waters Technologies CorporationInventors: Bonnie A. Alden, Kenneth Berthelette, Jon Finch, Donna Osterman, Thomas Swann, Thomas H. Walter
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Publication number: 20210349060Abstract: Described are multidimensional liquid chromatography (MDLC) systems and methods of performing MDLC. The MDLC systems includes valve configurations that enable a flow containing analytes in the eluent of a first dimension liquid chromatography system to be modulated such that the analytes can be captured in fluidic loops and subsequently provided to a second dimension liquid chromatography system. Various system embodiments are provided in a smaller instrument size, include an option to use the same detector for both first and second dimensions, enable improvement in valve timing operations and provide a reduction in the magnitude and effects of pressure pulses. In addition, the modulator can enable dilution of the analytes and enable incompatible mobile phases and mobile phase flow rates to be used in the first and second dimensions.Type: ApplicationFiled: May 4, 2021Publication date: November 11, 2021Inventors: Michael O. Fogwill, Sylvain Gilles Cormier, Thomas Swann, Francis Patrick Tracey
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Publication number: 20190195758Abstract: In various aspects, the present disclosure pertains to methods of performing a sample enrichment procedure, which comprise: adding a sample fluid that comprises at least one phospholipid and at least one target analyte to a sorbent that comprises a hydrophobic component and a cation exchange component, thereby resulting in sorbent with bound phospholipid and bound target analyte; adding an aqueous solution comprising an acidic compound and a salt; adding an organic solution to the sorbent thereby desorbing at least a portion of the bound phospholipid from the sorbent; and adding an elution solution to the sorbent, thereby desorbing at least a portion of the bound target analyte from the sorbent and forming a solution of the target analyte in the elution solution. In other aspects, the present disclosure pertains to kits, which may be used in conjunction with such methods.Type: ApplicationFiled: December 21, 2018Publication date: June 27, 2019Inventors: Bonnie A. Alden, Kenneth Berthelette, Jon Finch, Donna Osterman, Thomas Swann, Thomas H. Walter
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Patent number: 7831441Abstract: Responding to an account reactivation request includes receiving an account reactivation request from a former subscriber having a deactivated account and automatically accessing stored account information related to the deactivated account based on the account reactivation request. The stored account information is compared with a reactivation standard to produce a comparison result. Based on the comparison result a response to the reactivation request is provided. The receiving, accessing, comparing, and responding may be performed by a computer without interaction between the former subscriber and a service representative.Type: GrantFiled: June 27, 2008Date of Patent: November 9, 2010Assignee: AOL Inc.Inventors: Brad Joseph Juneau, Thomas Neal Donegan, Dmitri Vasilievich Kochetkov, Allen Thomas Swann, Patricia Carter Tobin, David Crane Bishop, Gregory John Weiss
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Patent number: 7395212Abstract: Responding to an account reactivation request includes receiving an account reactivation request from a former subscriber having a deactivated account and automatically accessing stored account information related to the deactivated account based on the account reactivation request. The stored account information is compared with a reactivation standard to produce a comparison result. Based on the comparison result a response to the reactivation request is provided. The receiving, accessing, comparing, and responding may be performed by a computer without interaction between the former subscriber and a service representative.Type: GrantFiled: May 21, 2001Date of Patent: July 1, 2008Assignee: AOL LLCInventors: Brad Joseph Juneau, Thomas Neal Donegan, Dmitri Vasilievich Kochetkov, Allen Thomas Swann, Patricia Carter Tobin, David Crane Bishop, Gregory John Weiss
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Publication number: 20020019739Abstract: Responding to an account reactivation request includes receiving an account reactivation request from a former subscriber having a deactivated account and automatically accessing stored account information related to the deactivated account based on the account reactivation request. The stored account information is compared with a reactivation standard to produce a comparison result. Based on the comparison result a response to the reactivation request is provided. The receiving, accessing, comparing, and responding may be performed by a computer without interaction between the former subscriber and a service representative.Type: ApplicationFiled: May 21, 2001Publication date: February 14, 2002Inventors: Brad Joseph Juneau, Thomas Neal Donegan, Dmitri Vasilievich Kochetkov, Allen Thomas Swann, Patricia Carter Tobin, David Crane Bishop, Gregory John Weiss
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Patent number: 6001836Abstract: A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of cyanoguanidine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.Type: GrantFiled: May 26, 1998Date of Patent: December 14, 1999Assignee: Bristol-Myers Squibb CompanyInventors: Graham S. Poindexter, R. Thomas Swann, Marc A. Bruce, Mendi A. Morton, Yazhong Huang, Sing-Yuen Sit, James Guy Breitenbucher
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Patent number: 5760084Abstract: Retinoid-like activity is exhibited by compounds of the formula ##STR1## wherein X is F, Cl, OH or CH.sub.3, Y is H or F, R.sub.1 -R.sub.6 are each independently hydrogen or C.sub.1 -C.sub.6 alkyl, n is an integer of 1 to 4 and R.sub.7 is hydrogen or a carboxyl-protecting group, and pharmaceutically acceptable salts thereof. The compounds of the formula I selectively interact with the retinoic acid subtype RAR.gamma. and have been found to lack the liver toxicity associated with systemic administration of non-relative retinoids.Type: GrantFiled: October 4, 1996Date of Patent: June 2, 1998Assignee: Bristol-Myers Squibb CompanyInventors: R. Thomas Swann, Daniel Smith, Kenneth M. Tramposch, Fred Christopher Zusi
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Patent number: 5624957Abstract: Retinoid-like activity is exhibited by compounds of the formula ##STR1## wherein X is F, Cl, OH or CH.sub.3, Y is H or F, R.sub.1 -R.sub.6 are each independently hydrogen or C.sub.1 -C.sub.6 alkyl, n is an integer of 1 to 4 and R.sub.7 is hydrogen or a carboxyl-protecting group, and pharmaceutically acceptable salts thereof. The compounds of formula I selectively interact with the retinoic acid subtype RAR.gamma. and have been found to lack the liver toxicity associated with systemic administration of non-selective retinoids.Type: GrantFiled: June 6, 1995Date of Patent: April 29, 1997Assignee: Bristol-Myers Squibb CompanyInventors: R. Thomas Swann, Daniel Smith, Kenneth M. Tramposch, Fred C. Zusi
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Patent number: 5086060Abstract: The effects of acne and psoriasis are relived by applying either topically or by oral adminstration, a compound having the structure: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently selected from the group consisting of H, Cl, straight or branched alkyl of 1 to 10 carbon atoms, NO.sub.2, COOR.sub.6, CN, OR.sub.6, NR.sub.6 R.sub.7, NR.sub.6 C(.dbd.S)NR.sub.7 R.sub.8, NF.sub.6 COR.sub.7, SO.sub.2 NR.sub.6 R.sub.7, CH(CH.sub.3)COOH, CONR.sub.6 R.sub.7, COR.sub.6, OCONR.sub.6 R.sub.7, NR.sub.6 COONR.sub.7, R.sub.9 OR.sub.6, NR.sub.6 SO.sub.2 R.sub.7, Si(CH.sub.3).sub.3, and NR.sub.6 CONR.sub.7 R.sub.8,R.sub.3 together with R.sub.4 forms a benzo ring or taken together with R.sub.2 forms a benzo or tetrahydrobenzo ring or together with R.sub.2 and R.sub.1 forms a: ##STR2## moiety or together with R.sub.2 forms a ##STR3## moiety or R.sub.2 together with R.sub.1 forms a benzo ring or R.sub.2 together with R.sub.3 forms a ##STR4## moiety, or R.sub.Type: GrantFiled: July 16, 1990Date of Patent: February 4, 1992Assignee: Eastman Kodak CompanyInventors: Neil F. Haley, Xina Nair, Gerard J. Gendimenico, F. Christopher Zusi, R. Thomas Swann
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Patent number: 4962988Abstract: In order to make possible the provision of a good fusion joint with low losses between an optical fiber and a graded index (GRIN) glass rod lens with considerably larger diameter, the end of the GRIN lens to which the optical fiber is to be joined is tapered down radially the extent of at least one third the radius of the cylindrical lens at an angle approximately 45.degree.. It is then possible to make a mechanically good fused joint with low transmission losses in the mid portion of the reduced-diameter end of the lens by heating the butt joint with an electric arc. The taper may be frusto-conical, convex or concave.Type: GrantFiled: July 10, 1989Date of Patent: October 16, 1990Assignee: Optomec Design CompanyInventor: Thomas A. Swann