Patents by Inventor Thomas A. ZANGLE

Thomas A. ZANGLE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160103118
    Abstract: In certain embodiments methods of identifying T cell receptors that respond to specific target cell antigens are provided, where the methods comprise providing a substrate bearing a plurality of target cells (e.g., mammalian cells); contacting the target cells on the substrate with CD8+ T cells; and using label-free optical imaging to identify an increase in mass of a T-cell and/or a decrease in mass of a target cell, where an increase in mass of a T cell and/or a decrease in mass of a target cell is an indicator that said T cell bears a T cell receptor activated by antigens presented on said target cell.
    Type: Application
    Filed: May 23, 2014
    Publication date: April 14, 2016
    Inventors: Michael A. TEITELL, Thomas A. ZANGLE, Owen N. WITTE, Daina Burnes LINTON