Patents by Inventor Thomas Agersten Poulsen

Thomas Agersten Poulsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220145273
    Abstract: The present invention relates to a variant of a parent lipase, which parent lipase has the amino acid sequence of SEQ ID NO: 2, wherein the variant has lipase activity, comprises a substitution at a position corresponding to position 51 and comprises a substitution or remains unaltered at a position corresponding to position 96 of SEQ ID NO: 2. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Application
    Filed: January 25, 2022
    Publication date: May 12, 2022
    Applicant: Novozymes A/S
    Inventors: Christian Lundager Gylstorff, Christian Jackel, Jesper Vind, Allan Svendsen, Marco Malten, Thomas Agersten Poulsen
  • Patent number: 11312946
    Abstract: The present invention relates to detergent compositions comprising a variant of a parent lipase which variant has lipase activity, has at least 60% but less than 100% sequence identity with SEQ ID NO: 2, and comprises substitutions at positions corresponding to T231R+N233R and at least one or more (e.g., several) of D96E, D111A, D254S, G163K, P256T, G91T, and G38A of SEQ ID NO: 2. The present invention also relates to use of the compositions, methods of producing the compositions, and methods of cleaning. The present invention furthermore relates to variants and polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: April 26, 2022
    Assignee: NOVOZYMES A/S
    Inventors: Marco Malten, Kim Borch, Lise Munch Mikkelsen, Thomas Agersten Poulsen, Luise Erlandsen, Hanne Philbert Nielsen, Carsten Horslev Hansen, Allan Svendsen, Christian Lundager Gylstorff, Jesper Vind, Christian Jackel
  • Patent number: 11268076
    Abstract: The present invention relates to a variant of a parent lipase, which parent lipase has the amino acid sequence of SEQ ID NO: 2, wherein the variant has lipase activity, comprises a substitution at a position corresponding to position 51 and comprises a substitution or remains unaltered at a position corresponding to position 96 of SEQ ID NO: 2. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: March 8, 2022
    Assignee: Novozymes A/S
    Inventors: Christian Lundager Gylstorff, Christian Jackel, Jesper Vind, Allan Svendsen, Marco Malten, Thomas Agersten Poulsen
  • Patent number: 11203790
    Abstract: The present invention relates to glucoamylase variants, polynucleotides encoding the variants, methods of producing the variants, and methods of using the variants. Also described are the use of glucoamylases of the invention for starch conversion to produce fermentation products, such as ethanol, and syrups, such as glucose. The invention also relates to a composition comprising a glucoamylase variant of the invention.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: December 21, 2021
    Assignee: NOVOZYMES A/S
    Inventors: Shikha Gupta, Allan Svendsen, Vivek Srivastava, Marco Malten, Thomas Agersten Poulsen, Preethi Ramaiya, Beth Nelson, Vasudeva Prahlada Rao, Padmavathi Balumuri
  • Publication number: 20210363510
    Abstract: Disclosed is variants of a cellulase having improved stability in the presence of a protease, and the use of such variants in laundry.
    Type: Application
    Filed: April 12, 2019
    Publication date: November 25, 2021
    Applicant: Novozymes A/S
    Inventors: Svend Gunnar Kaasgaard, Frank Winther Rasmussen, Roland Alexander Pache, Lars Anderson, Mette Louise Dissing Overgaard, Thomas Agersten Poulsen, Dorte Marie Koefoed Klitgaard, Christian Isak Joergensen, Lars Giger
  • Publication number: 20210071156
    Abstract: The present invention relates to lipase variants of the parent lipase shown as SEQ ID NO: 2 with improved stability during use in a wash process (IWS). The invention also relates to polynucleotides encoding the lipase variants of the invention, compositions comprising a lipase variant of the invention as well as methods of producing such lipase variants of the invention and the use of the lipase variants or compositions thereof.
    Type: Application
    Filed: February 8, 2019
    Publication date: March 11, 2021
    Applicant: Novozymes A/S
    Inventors: Sune Fang Christensen, Allan Svendsen, Jesper Vind, Anders Gunnar Sandtrom, Thomas Agersten Poulsen, Alexander David Fulton, Carsten Hoerslev Hansen, Vibeke Skovgaard Nielsen, Kim Borch, Garry Paul Gippert
  • Publication number: 20210071155
    Abstract: The present invention relates to lipase variants of the parent lipase shown as SEQ ID NO: 2 with improved wash performance and/or Benefit Risk Factor (BRF). The invention also relates to polynucleotides encoding the lipase variants of the invention, compositions comprising a lipase variant of the invention as well as methods of producing such lipase variants of the invention and the use of the lipase variants or compositions thereof.
    Type: Application
    Filed: February 8, 2019
    Publication date: March 11, 2021
    Applicant: Novozymes A/S
    Inventors: Sune Fang Christensen, Allan Svendsen, Jesper Vind, Anders Gunnar Sandtrom, Thomas Agersten Poulsen, Alexander David Fulton, Carsten Hoerslev Hansen, Vibeke Skovgaard Nielsen, Kim Borch, Garry Paul Gippert
  • Publication number: 20210071157
    Abstract: The present invention relates to lipase variants of the parent lipase shown as SEQ ID NO: 2 with improved wash performance and/or Benefit Risk Factor (BRF). The invention also relates to polynucleotides encoding the lipase variants of the invention, compositions comprising a lipase variant of the invention as well as methods of producing such lipase variants of the invention and the use of the lipase variants or compositions thereof.
    Type: Application
    Filed: February 8, 2019
    Publication date: March 11, 2021
    Applicant: Novozymes A/S
    Inventors: Sune Fang Christensen, Allan Svendsen, Jesper Vind, Anders Gunnar Sandtrom, Thomas Agersten Poulsen, Alexander David Fulton, Carsten Hoerslev Hansen, Vibeke Skovgaard Nielsen, Kim Borch, Garry Paul Gippert
  • Publication number: 20210047628
    Abstract: Disclosed are variants of a cellulase having improved stability in the presence of a protease, and the use of such variants in laundry.
    Type: Application
    Filed: April 12, 2019
    Publication date: February 18, 2021
    Applicant: Novozymes A/S
    Inventors: Svend Gunnar Kaasgaard, Frank Winther Rasmussen, Roland Alexander Pache, Lars Anderson, Mette Louise Dissing Overgaard, Thomas Agersten Poulsen, Lars Giger
  • Patent number: 10760037
    Abstract: The present invention relates to a composition comprising: (a) a source of sulfite; and (b) a lipase variant of a parent lipase, wherein said variant has improved stability towards sulfite as compared to the parent lipase.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: September 1, 2020
    Assignee: NOVOZYMES A/S
    Inventors: Marco Malten, Thomas Agersten Poulsen, Lise Munch Mikkelsen, Dorte Marie Koefoed Klitgaard, Vibeke Skovgaard Nielsen, Katarina Larson
  • Publication number: 20200199551
    Abstract: The present invention relates to variants of a parent lipase which has lipase activity and comprise one or more substitutions corresponding to G23S, D27N, A40I, F51I,L, E56R, D57N, V60E,K, K98I, N101D, R118F, G163S, T231R, N233R, Y220F, T244E, and P256T using SEQ ID NO: 2 for numbering. The present invention also relates to compositions or microcapsule compositions comprising a lipase variant of the invention and to liquid products comprising a microcapsule composition of the invention as well as the use of said microcapsule composition for stabilizing lipase variants of the invention.
    Type: Application
    Filed: September 25, 2018
    Publication date: June 25, 2020
    Applicant: Novozymes A/S
    Inventors: Miguel Duarte Guilherme Pereira Toscano, Thomas Agersten Poulsen, Carsten Horslev Hansen, Lone Baunsgaard, Keith Gibson
  • Publication number: 20200140965
    Abstract: The present invention relates to glucoamylase variants having an increase in specific activity and/or an increase in melting temperature measured by TSA of at least 0.5 degrees Celsius, and further wherein the variants have at least at least 85%, at least 90%, at least 95% identity, at least 96%, at least 97%, at least 98%, or at least 99%, but less than 100%, sequence identity to the amino acid sequence of SEQ ID NO: 3. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Application
    Filed: October 18, 2019
    Publication date: May 7, 2020
    Applicant: NOVOZYMES A/S
    Inventors: Shikha Gupta, Allan Svendsen, Vivek Srivastava, Marco Malten, Thomas Agersten Poulsen, Preethi Ramaiya, Beth Nelson, Vasudeva Prahlada Rao, Padmavathi Balumuri
  • Publication number: 20200123518
    Abstract: The present invention relates to variants of a parent alpha-amylase. The present invention also relates to polynucleotides encoding the variants and to nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the variant enzymes.
    Type: Application
    Filed: December 16, 2019
    Publication date: April 23, 2020
    Applicants: NOVOZYMES A/S, NOVOZYMES NORTH AMERICA, INC.
    Inventors: Carsten Andersen, Randall Deinhammer, Thomas Agersten Poulsen, Miguel Duarte Toscano, Peter Kamp Hansen, Henrik Friis-Madsen, Anders Viksoe-Nielsen, Signe Eskildsen Larsen, Lars L.H. Christensen
  • Patent number: 10550373
    Abstract: The present invention relates to variants of a parent alpha-amylase. The present invention also relates to polynucleotides encoding the variants and to nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the variant enzymes.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: February 4, 2020
    Assignees: NOVOZYMES A/S, NOVOZYMES NORTH AMERICA, INC.
    Inventors: Carsten Andersen, Randall Deinhammer, Thomas Agersten Poulsen, Miguel Duarte Toscano, Peter Kamp Hansen, Henrik Friis-Madsen, Anders Viksoe-Nielsen, Signe Eskildsen Larsen, Lars L. H. Christensen
  • Patent number: 10494685
    Abstract: The present invention relates to glucoamylase variants having an increase in specific activity and/or an increase in melting temperature measured by TSA of at least 0.5 degrees Celsius, and further wherein the variants have at least at least 85%, at least 90%, at least 95% identity, at least 96%, at least 97%, at least 98%, or at least 99%, but less than 100%, sequence identity to the amino acid sequence of SEQ ID NO: 3. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: December 3, 2019
    Assignee: NOVOZYMES A/S
    Inventors: Shikha Gupta, Allan Svendsen, Vivek Srivastava, Marco Malten, Thomas Agersten Poulsen, Preethi Ramaiya, Beth Nelson, Vasudeva P. Rao, Padmavathi Balumuri
  • Publication number: 20190284541
    Abstract: The present invention relates to detergent compositions comprising a variant of a parent lipase which variant has lipase activity, has at least 60% but less than 100% sequence identity with SEQ ID NO: 2, and comprises substitutions at positions corresponding to T231R+N233R and at least one or more (e.g., several) of D96E, D111A, D254S, G163K, P256T, G91T, and G38A of SEQ ID NO: 2. The present invention also relates to use of the compositions, methods of producing the compositions, and methods of cleaning. The present invention furthermore relates to variants and polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides.
    Type: Application
    Filed: May 28, 2019
    Publication date: September 19, 2019
    Applicant: NOVOZYMES A/S
    Inventors: Marco Malten, Kim Borch, Lise Munch Mikkelsen, Thomas Agersten Poulsen, Luise Erlandsen, Hanne Philbert Nielsen, Carsten Horslev Hansen, Allan Svendsen, Christian Lundager Gylstorff, Jesper Vind, Christian Jackel
  • Patent number: 10351833
    Abstract: The present invention relates to detergent compositions comprising a variant of a parent lipase which variant has lipase activity, has at least 60% but less than 100% sequence identity with SEQ ID NO: 2, and comprises substitutions at positions corresponding to T231R+N233R and at least one or more (e.g., several) of D96E, D111A, D254S, G163K, P256T, G91T, and G38A of SEQ ID NO: 2. The present invention also relates to use of the compositions, methods of producing the compositions, and methods of cleaning. The present invention furthermore relates to variants and polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: July 16, 2019
    Assignee: Novozymes A/S
    Inventors: Marco Malten, Kim Borch, Lise Munch Mikkelsen, Thomas Agersten Poulsen, Luise Erlandsen, Hanne Philbert Nielsen, Carsten Horslev Hansen, Allan Svendsen, Christian Lundager Gylstorff, Jesper Vind, Christian Jackel
  • Publication number: 20190071619
    Abstract: The present invention relates to a composition comprising: (a) a source of sulfite; and (b) a lipase variant of a parent lipase, wherein said variant has improved stability towards sulfite as compared to the parent lipase.
    Type: Application
    Filed: July 1, 2016
    Publication date: March 7, 2019
    Applicant: NOVOZYMES A/S
    Inventors: Marco Malten, Thomas Agersten Poulsen, Lise Munch Mikkelsen, Dorte Marie Koefoed Klitgaard, Vibeke Skovgaard Nielsen, Katarina Larson
  • Publication number: 20190048413
    Abstract: The present invention enables the determination by NGS of the full nucleotide sequence of one or more polynucleotides of interest that are more than 800 bp in length after only one round of PCR amplification and subsequent fragmentation by adding at least one known oligonucleotide index to at least one end of each polynucleotide to produce elongated polynucleotides, wherein each known oligonucleotide index added to each polynucleotide is unique; fragmenting the elongated polynucleotides; sequencing the resulting fragments with paired forward and reverse reads using bridge amplification and next-generation sequencing; sorting the paired sequences based on the known oligonucleotide; and performing manual or in silico assembly of the sorted paired sequences, thereby providing the full coding sequence of each of the multitude of polynucleotides.
    Type: Application
    Filed: February 23, 2017
    Publication date: February 14, 2019
    Applicant: NOVOZYMES A/S
    Inventors: Marco Malten, Thomas Agersten Poulsen, Preethi Ramaiya, Michael Bargisen, Beth Nelson
  • Patent number: 10138473
    Abstract: The present invention relates to proteases having at least 75% identity to a protease derived from Thermoascus aurantiacus and comprises at least one modification in the amino acid sequence thereof. These protease variants have improved thermostability. The invention also relates to DNA encoding these proteases, methods of their production, as well as the use thereof.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: November 27, 2018
    Assignee: NOVOZYMES A/S
    Inventors: Tomoko Matsui, Allan Noergaard, Thomas Agersten Poulsen, John Matthews