Patents by Inventor Thomas Albert Zeibig

Thomas Albert Zeibig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing heterocyclic indene analogs
    Patent number: 7169935
    Abstract: A process for the preparation heterocyclic indene analogs, especially with the preparation of 4-hydroxycarbazole or N-protected 4-hydroxycarbazole, involves cyclocarbonylation followed by saponification. This process avoids high temperatures and high catalyst loadings.
    Type: Grant
    Filed: January 22, 2004
    Date of Patent: January 30, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michelangelo Scalone, Thomas Albert Zeibig
  • Process for preparing heterocyclic indene analogs
    Patent number: 6777559
    Abstract: A process for the preparation heterocyclic indene analogs, especially with the preparation of 4-hydroxycarbazole or N-protected 4-hydroxycarbazole, involves cyclocarbonylation followed by saponification. This process avoids high temperatures and high catalyst loadings.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: August 17, 2004
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michelangelo Scalone, Thomas Albert Zeibig
  • Process for preparing heterocyclic indene analogs
    Publication number: 20040127723
    Abstract: A process for the preparation heterocyclic indene analogs, especially with the preparation of 4-hydroxycarbazole or N-protected 4-hydroxycarbazole, involves cyclocarbonylation followed by saponification. This process avoids high temperatures and high catalyst loadings.
    Type: Application
    Filed: January 22, 2004
    Publication date: July 1, 2004
    Inventors: Michelangelo Scalone, Thomas Albert Zeibig
  • Methods for the preparation of 4-hydroxy benzothiophene
    Patent number: 6482958
    Abstract: The present invention is concerned with a novel process for the preparation of a hydroxybenzothiophene that is an intermediate for synthesizing pharmaceutically active substances, e.g. 5-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-7-benzothiophenylmethyl]-2,4-thiazolidinedione and the corresponding sodium salt which are useful in the treatment of diabetes.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: November 19, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernd Junghans, Michelangelo Scalone, Thomas Albert Zeibig
  • Methods for the preparation of 4-hydroxy benzothiophene
    Patent number: 6437144
    Abstract: The present invention is concerned with a novel process for the preparation of the hydroxybenzothiophene of formula I comprising cyclocarbonylation of a compound of formula II wherein Y is as defined in the specification, followed by saponification. The compound of Formula I is a building block of pharmaceutically active substances, e.g. 5-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-7-benzothiophenylmethyl]-2,4-thiazolidinedione and the corresponding sodium salt which are from agents useful in the treatment of diabetes.
    Type: Grant
    Filed: May 8, 2001
    Date of Patent: August 20, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernd Junghans, Michelangelo Scalone, Thomas Albert Zeibig
  • Process for preparing heterocyclic indene analogs
    Publication number: 20020099223
    Abstract: A process for the preparation heterocyclic indene analogs, especially with the preparation of 4-hydroxycarbazole or N-protected 4-hydroxycarbazole, involves cyclocarbonylation followed by saponification. This process avoids high temperatures and high catalyst loadings.
    Type: Application
    Filed: January 22, 2002
    Publication date: July 25, 2002
    Inventors: Michelangelo Scalone, Thomas Albert Zeibig
  • Methods for the preparation of 4-hydroxy benzothiophene
    Publication number: 20020077488
    Abstract: The present invention is concerned with a novel process for the preparation of a hydroxybenzothiophene that is an intermediate for synthesizing pharmaceutically active substances, e.g. 5- [4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-7-benzothiophenylmethyl]-2,4-thiazolidinedione and the corresponding sodium salt which are useful in the treatment of diabetes.
    Type: Application
    Filed: November 8, 2001
    Publication date: June 20, 2002
    Inventors: Bernd Junghans, Michelangelo Scalone, Thomas Albert Zeibig
  • Methods for the preparation of 4-hydroxybenzothiophene
    Patent number: 6291685
    Abstract: The present invention is concerned with a novel process for the preparation of the hydroxybenzothiophene of formula I comprising cyclocarbonylation of a compound of formula II wherein Y is as defined in the specification, followed by saponification. The compound of Formula I is a building block of pharmaceutically active substances, e.g. 5-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-7-benzothiophenylmethyl]-2,4-thiazolidinedione and the corresponding sodium salt which are from agents useful in the treatment of diabetes.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: September 18, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernd Junghans, Michelangelo Scalone, Thomas Albert Zeibig