Patents by Inventor Thomas Aldrich
Thomas Aldrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210009714Abstract: Recombinant cell surface capture proteins and detection molecules that are useful for isolating and detecting cells that produce a secreted heterodimeric protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain are provided. Recombinant cell surface capture proteins and detection molecules that isolate and detect bispecific antibodies are also provided. The invention also provides recombinant antigen-binding proteins that are capable of recognizing and binding to proteins of interest that contain a CH3 domain and/or a modified CH3 domain, such as a CH3 domain with or without amino acid substitutions at H95 and Y96 (IMGT).Type: ApplicationFiled: September 18, 2020Publication date: January 14, 2021Inventors: Dipali Deshpande, Gang Chen, Darya Burakov, James Fandl, Thomas Aldrich, Vishal Kamat
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Patent number: 10238118Abstract: The disclosure describes fungal organisms and preparations useful for inhibiting infection by Xylella sp. and in the treatment of Pierce's Disease.Type: GrantFiled: September 2, 2016Date of Patent: March 26, 2019Assignee: The Regents of the University of CaliforniaInventors: Philippe Rolshausen, Mary Caroline Roper, Katherine Maloney, Thomas Aldrich
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Publication number: 20180118852Abstract: Recombinant cell surface capture proteins and detection molecules that are useful for isolating and detecting cells that produce a secreted heterodimeric protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain are provided. Recombinant cell surface capture proteins and detection molecules that isolate and detect bispecific antibodies are also provided. The invention also provides recombinant antigen-binding proteins that are capable of recognizing and binding to proteins of interest that contain a CH3 domain and/or a modified CH3 domain, such as a CH3 domain with or without amino acid substitutions at H95 and Y96 (IMGT).Type: ApplicationFiled: September 11, 2017Publication date: May 3, 2018Inventors: Dipali Deshpande, Gang Chen, Darya Burakov, James Fandl, Thomas Aldrich, Vishal Kamat
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Patent number: 9758592Abstract: Recombinant cell surface capture proteins and detection molecules that are useful for isolating and detecting cells that produce a secreted heterodimeric protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain are provided. Recombinant cell surface capture proteins and detection molecules that isolate and detect bispecific antibodies are also provided. The invention also provides recombinant antigen-binding proteins that are capable of recognizing and binding to proteins of interest that contain a CH3 domain and/or a modified CH3 domain, such as a CH3 domain with or without amino acid substitutions at H95 and Y96 (IMGT).Type: GrantFiled: November 14, 2013Date of Patent: September 12, 2017Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Dipali Deshpande, Gang Chen, Darya Burakov, James Fandl, Thomas Aldrich, Vishal Kamat
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Publication number: 20170241887Abstract: A method of detecting and isolating cells that produce a secreted protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain, comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule.Type: ApplicationFiled: February 27, 2017Publication date: August 24, 2017Inventors: James P. Fandl, Gang Chen, Neil Stahl, George D. Yancopoulos, Dipali Deshpande, Darya Burakov, Thomas Aldrich, Vishal Kamat
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Publication number: 20140134719Abstract: Recombinant cell surface capture proteins and detection molecules that are useful for isolating and detecting cells that produce a secreted heterodimeric protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain are provided. Recombinant cell surface capture proteins and detection molecules that isolate and detect bispecific antibodies are also provided. The invention also provides recombinant antigen-binding proteins that are capable of recognizing and binding to proteins of interest that contain a CH3 domain and/or a modified CH3 domain, such as a CH3 domain with or without amino acid substitutions at H95 and Y96 (IMGT).Type: ApplicationFiled: November 14, 2013Publication date: May 15, 2014Applicant: Regeneron Pharmaceuticals, Inc.Inventors: DIPALI DESHPANDE, GANG CHEN, DARYA BURAKOV, JAMES FANDL, THOMAS ALDRICH, VISHAL KAMAT
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Publication number: 20140072980Abstract: A method of detecting and isolating cells that produce a secreted protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain, comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule.Type: ApplicationFiled: November 14, 2013Publication date: March 13, 2014Applicant: Regeneron Pharmaceuticals, Inc.Inventors: JAMES P. FANDL, GANG CHEN, NEIL STAHL, GEORGE D. YANCOPOULOS, DIPALI DESHPANDE, DARYA BURAKOV, THOMAS ALDRICH, VISHAL KAMAT
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Publication number: 20140072979Abstract: A method of detecting and isolating cells that produce a secreted protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain, comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule.Type: ApplicationFiled: November 14, 2013Publication date: March 13, 2014Applicant: Regeneron Pharmaceuticals, Inc.Inventors: JAMES P. FANDL, GANG CHEN, NEIL STAHL, GEORGE D. YANCOPOULOS, DIPALI DESHPANDE, DARYA BURAKOV, THOMAS ALDRICH, VISHAL KAMAT
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Publication number: 20050158829Abstract: A fusion polypeptide comprising (A)x—M—(A?)y, wherein A and A? are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins which activate the target receptor. A and A? may be each be an antibody or fragment derived from an antibody specific for a target receptor, such as the same or different ScFv fragmetns, and/or a ligand or ligand fragment or derivative capable of binding the target protein, M is a multimerizing component, and X and Y are independently a number between 1-10.Type: ApplicationFiled: January 14, 2005Publication date: July 21, 2005Inventors: James Fandl, Gang Chen, Nicholas Papadopoulos, Thomas Aldrich
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Patent number: 5643755Abstract: The present invention provides for TIE-2 ligand substantially free of other proteins. The invention also provides for an isolated nucleic acid molecule encoding TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds TIE-2 ligand. The invention also provides an antibody which specifically binds TIE-2 ligand. The invention further provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization and a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor.Type: GrantFiled: October 7, 1994Date of Patent: July 1, 1997Assignee: Regeneron Pharmaceuticals Inc.Inventors: Samuel Davis, Thomas Aldrich, George D. Yancopoulos
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Patent number: D244425Type: GrantFiled: March 24, 1975Date of Patent: May 24, 1977Assignee: The Clorox CompanyInventors: Thomas Aldrich, Albert Torongo
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Patent number: D271790Type: GrantFiled: January 16, 1981Date of Patent: December 13, 1983Assignee: Thermo-Tech Corp.Inventor: Thomas Aldrich
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Patent number: D342678Type: GrantFiled: April 1, 1992Date of Patent: December 28, 1993Assignee: S. C. Johnson & Son, Inc.Inventors: Jim Warner, Thomas Aldrich
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Patent number: D382809Type: GrantFiled: February 15, 1996Date of Patent: August 26, 1997Assignee: Societe des Produits Nestle S.A.Inventors: Thomas Aldrich, Douglas H. Novakoski, James Warner
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Patent number: D382810Type: GrantFiled: February 15, 1996Date of Patent: August 26, 1997Assignee: Societe des Produits Nestle S.A.Inventors: Thomas Aldrich, Douglas H. Novakoski, James Warner