Patents by Inventor Thomas Ammann

Thomas Ammann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONCENTRATED SOLUTIONS COMPRISING 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID
    Publication number: 20260000671
    Abstract: The present invention relates to stable high-content solutions comprising 5,10-methylene-(6R)-tetrahydrofolic acid (5,10-CH2-(6R)-THF), which solutions are free of extraneous stabilizing agents.
    Type: Application
    Filed: June 5, 2023
    Publication date: January 1, 2026
    Inventors: Rudolf Moser, Viola Groehn, Thomas Ammann, Jean-Pierre Knapp, Marianne Svaerd
  • COMPOSITIONS COMPRISING DISODIUM 5,10-METHYLENE-(6R)-TETRAHYDROFOLATE
    Publication number: 20250360135
    Abstract: The present invention relates to stable formulations and lyophilizates comprising a high content of the disodium salt of 5,10-methylene-(6R)-tetrahydrofolic acid, sulfate and citrate.
    Type: Application
    Filed: June 5, 2023
    Publication date: November 27, 2025
    Applicant: MERCK PATENT GMBH
    Inventors: Rudolf MOSER, Viola GROEHN, Thomas AMMANN, Jean-Pierre KNAPP, Marianne SVAERD
  • STABLE LYOPHILISATES COMPRISING 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID
    Publication number: 20250319089
    Abstract: The present invention relates to stable lyophilizates comprising a high content of 5,10-methylene-(6R)-tetrahydrofolic acid, which compositions do not contain any extraneous stabilizers or further chemotherapeutic agents.
    Type: Application
    Filed: June 5, 2023
    Publication date: October 16, 2025
    Inventors: Rudolf Moser, Viola Groehn, Thomas Ammann, Jean-Pierre Knapp, Marianne Svaerd
  • CONCENTRATED SOLUTIONS COMPRISING SODIUM 5,10-METHYLENE-(6R)-TETRAHYDROFOLATE
    Publication number: 20250319022
    Abstract: The present invention relates to liquid compositions comprising a high content of the sodium salt of 5,10-methyl-ene-(6R)-tetrahydrofolic acid and sulfate, which formulations and lyophilizates do not contain any extraneous stabilizers.
    Type: Application
    Filed: June 5, 2023
    Publication date: October 16, 2025
    Inventors: Rudolf Moser, Viola Groehn, Thomas Ammann, Jean-Pierre Knapp, Marianne Svaerd
  • NEW STABLE SALT OF 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID
    Publication number: 20240400574
    Abstract: The present invention is directed towards the hemisulfate salt of 5,10-methylene-(6R)-tetrahydrofolic acid, preferably in substantially crystalline form, as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
    Type: Application
    Filed: August 9, 2024
    Publication date: December 5, 2024
    Applicant: MERCK & CIE
    Inventors: Rudolf MOSER, Viola GROEHN, Thomas EGGER, Thomas AMMANN
  • Stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid
    Patent number: 12122783
    Abstract: The present invention is directed towards the hemisulfate salt of 5,10-methylene-(6R)-tetrahydrofolic acid, preferably in substantially crystalline form, as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
    Type: Grant
    Filed: October 8, 2021
    Date of Patent: October 22, 2024
    Assignee: MERCK & CIE
    Inventors: Rudolf Moser, Viola Groehn, Thomas Egger, Thomas Ammann
  • Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
    Patent number: 12103930
    Abstract: The invention is directed towards stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid and its hemisulfate salt as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
    Type: Grant
    Filed: January 25, 2022
    Date of Patent: October 1, 2024
    Assignee: MERCK & CIE
    Inventors: Rudolf Moser, Viola Groehn, Thomas Egger, Thomas Ammann
  • DEVICE AND METHOD FOR DIRECT ENERGY DEPOSITION ADDITIVE MANUFACTURING (DED)
    Publication number: 20240123533
    Abstract: The present invention relates to a device and a method for DED or WAAM, comprising a welding torch configured to generate an arc for generating a melt pool on a surface of a workpiece, and a wire feeder configured to feed a wire towards the melt pool to generate a weld seam on said surface, and an enclosure enclosing at least part of the workpiece and comprising a process atmosphere with a process gas, wherein a sucking device sucks part of the process gas out of the enclosure and thereafter re-introduces the process gas into the process atmosphere, and wherein the enclosure comprises or consists of a flexible housing or a tent and in the sucking device is connected to a buffer volume or a pressure stabilizing unit.
    Type: Application
    Filed: February 21, 2022
    Publication date: April 18, 2024
    Inventors: Thomas AMMANN, Ian HIBBITT, Dominik BAUER, Julio COROADO
  • DYNAMIC MIXTURE OF SHIELDING GASES
    Publication number: 20220314356
    Abstract: The invention relates to a method for the dynamic feeding of shielding gas, comprising feeding a shielding gas to a component in a welding operation, sending the temperature of a region of the component; and setting a composition of the shielding gas according to the sensed temperature.
    Type: Application
    Filed: July 6, 2020
    Publication date: October 6, 2022
    Inventor: Thomas AMMANN
  • Stable lyophilisates comprising 5,10-methylene-(6R)-tetrahydrofolic acid
    Patent number: 11337978
    Abstract: The present invention is directed to stable lyophilisates comprising 5,10-methylene-(6R)-tetrahydrofolic acid or a pharmaceutically acceptable salt thereof and a dicarboxylic acid, or a salt thereof, as well as, a processes of obtaining the same, and the use of such products.
    Type: Grant
    Filed: August 15, 2018
    Date of Patent: May 24, 2022
    Assignee: Merck Patent GmbH
    Inventors: Rudolf Moser, Viola Groehn, Thomas Ammann
  • Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
    Publication number: 20220143027
    Abstract: The invention is directed towards stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid and its hemisulfate salt as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
    Type: Application
    Filed: January 25, 2022
    Publication date: May 12, 2022
    Applicant: MERCK & CIE
    Inventors: Rudolf MOSER, Viola GROEHN, Thomas EGGER, Thomas AMMANN
  • Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
    Patent number: 11306094
    Abstract: The invention is directed towards stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid and its hemisulfate salt as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: April 19, 2022
    Assignee: MERCK & CIE
    Inventors: Rudolf Moser, Viola Groehn, Thomas Egger, Thomas Ammann
  • STABLE SALT OF 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID
    Publication number: 20220024940
    Abstract: The present invention is directed towards the hemisulfate salt of 5,10-methylene-(6R)-tetrahydrofolic acid, preferably in substantially crystalline form, as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
    Type: Application
    Filed: October 8, 2021
    Publication date: January 27, 2022
    Applicant: MERCK & CIE
    Inventors: Rudolf MOSER, Viola GROEHN, Thomas EGGER, Thomas AMMANN
  • Stable lyophilisates comprising 5,10-methylene-(6R)-tetrahydrofolic acid
    Publication number: 20200368236
    Abstract: The present invention is directed to stable lyophilisates comprising 5,10-methylene-(6R)-tetrahydrofolic acid or a pharmaceutically acceptable salt thereof and a dicarboxylic acid, or a salt thereof, as well as, a processes of obtaining the same, and the use of such products.
    Type: Application
    Filed: August 15, 2018
    Publication date: November 26, 2020
    Applicant: Merck Patent GmbH
    Inventors: Rudolf MOSER, Viola GROEHN, Thomas AMMANN
  • Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
    Publication number: 20200283443
    Abstract: The invention is directed towards stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid and its hemisulfate salt as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
    Type: Application
    Filed: February 20, 2020
    Publication date: September 10, 2020
    Applicant: MERCK & CIE
    Inventors: Rudolf MOSER, Viola GROEHN, Thomas EGGER, Thomas AMMANN
  • Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
    Patent number: 10570134
    Abstract: The invention is directed towards stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid and its hemisulfate salt as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: February 25, 2020
    Assignee: MERCK & CIE
    Inventors: Rudolf Moser, Viola Groehn, Thomas Egger, Thomas Ammann
  • Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
    Publication number: 20190270745
    Abstract: The invention is directed towards stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid and its hemisulfate salt as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
    Type: Application
    Filed: May 17, 2019
    Publication date: September 5, 2019
    Applicant: MERCK & CIE
    Inventors: Rudolf MOSER, Viola GROEHN, Thomas EGGER, Thomas AMMANN
  • Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
    Patent number: 10336758
    Abstract: The invention is directed towards stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid and its hemisulfate salt as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: July 2, 2019
    Assignee: MERCK & CIE
    Inventors: Rudolf Moser, Viola Groehn, Thomas Egger, Thomas Ammann
  • NEW STABLE SALT OF 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID
    Publication number: 20190106431
    Abstract: The present invention is directed towards the hemisulfate salt of 5,10-methylene-(6R)-tetrahydrofolic acid, preferably in substantially crystalline form, as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
    Type: Application
    Filed: December 6, 2018
    Publication date: April 11, 2019
    Applicant: MERCK & CIE
    Inventors: Rudolf MOSER, Viola GROEHN, Thomas EGGER, Thomas AMMANN
  • Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
    Patent number: 10059710
    Abstract: The invention is directed towards stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid and its hemisulfate salt as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: August 28, 2018
    Assignee: MERCK & CIE
    Inventors: Rudolf Moser, Viola Groehn, Thomas Egger, Thomas Ammann