Abstract: Disclosed herein is a composition comprising: an amorphous solid dispersion (ASD) comprising nilotinib and at least one polymeric stabilizing and matrix-forming component; and at least one solid organic acid in admixture with the ASD, and uses thereof in the treatment of proliferative disorder.

Abstract: A heat exchanger assembly is proposed comprising: a heat exchanger forming one or more electrically connected partitions separating a first fluid and a second fluid. The assembly further comprises: a first electrical connector and a second electrical connector that are operationally connected to the partitions of the heat exchanger and an electrical power source operationally connected to the first electrical connector and the second electrical connector. The electrical power source is configured to supply an electric current to the one or more partitions of the heat exchange via the first electrical connector and the second electrical connector.

Abstract: The present disclosure relates to pharmaceutical compositions suitable for oral administration, and more particularly to pharmaceutical compositions, including pharmaceutical tablet compositions, containing (2S)-N-{(1S)-1-cyano-2-[4-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide (Compound A) or a pharmaceutically acceptable salt thereof.

Abstract: A crankcase gas separator includes a separator housing delimiting at least part of a separation space and forming at least part of a liquid phase receiving circumferential inner wall surface, a wall member forming at least part of a gas passage, and a gas pressure regulating valve including at least part of the gas passage. The separator includes a separate tube member extending from a position radially inside the inner wall surface into the gas passage. A liquid tight seal between the separate tube member and the wall member is formed by a joint arranged radially outside the inner wall surface.

Abstract: A crankcase gas separator includes a separator housing delimiting at least part of a separation space and forming at least part of a liquid phase receiving circumferential inner wall surface, a wall member forming at least part of a gas passage, and a gas pressure regulating valve including at least part of the gas passage. The separator includes a separate tube member extending from a position radially inside the inner wall surface into the gas passage. A liquid tight seal between the separate tube member and the wall member is formed by a joint arranged radially outside the inner wall surface.

Abstract: A heat exchanger assembly (10) is proposed comprising: a heat exchanger (12) forming one or more electrically connected partitions (26) separating a first fluid (22) and a second fluid (24). The assembly (10) further comprises: a first electrical connector (14) and a second electrical connector (16) that are operationally connected to the partitions (26) of the heat exchanger (12) and an electrical power source (18) operationally connected to the first electrical connector (14) and the second electrical connector (16). The electrical power source (18) is configured to supply an electric current to the one or more partitions (26) of the heat exchanger (12) via the first electrical connector (14) and the second electrical connector (16).

Abstract: The present disclosure relates to pharmaceutical compositions suitable for oral administration, and more particularly to pharmaceutical compositions, including pharmaceutical tablet compositions, containing (2S)-N-{(1S)-1-cyano-2-[4-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide (Compound A) or a pharmaceutically acceptable salt thereof.

Abstract: A drill device for drilling holes in components includes: a housing having a first motion link, and a drill spindle unit arranged at least partially in the housing. The drill spindle unit includes a drill assembly which is guided in the first motion link. The drill assembly includes bearings, a first coupling portion, and a drill axle configured to receive a drill. The drill axle is embedded in the bearings and is configured to rotate about a longitudinal axis. The drill spindle unit further includes at least a first elastic element that is abutting the housing with one end and the drill assembly with the other end, whereby the first elastic element is at least partially compressed when it is mounted in the drill device.

Abstract: The present disclosure relates to pharmaceutical compositions suitable for oral administration, and more particularly to pharmaceutical compositions, including pharmaceutical tablet compositions, containing (2S)-N-{(1S)-1-cyano-2-[4-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide (Compound A) or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to pharmaceutical compositions suitable for oral administration, and more particularly to pharmaceutical compositions, including pharmaceutical tablet compositions, containing (2S)-N-{(1S)-1-cyano-2-[4-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide (Compound A) or a pharmaceutically acceptable salt thereof.

Abstract: A catheter system (10) is proposed for preventing biological growth on a catheter (12). The system comprises: a catheter (12) comprising a tube (24) having an inner surface (18), an outer surface (20), and at least a first layer (16) comprising a flexible and electrically conductive first polymer material arranged to conduct an electric current along the tube (24). The system (10) further comprises: an electric power source (14) configured to generate an electric current in the first layer (16).

Abstract: A heat exchanger assembly (10) is proposed comprising: a heat exchanger (12) forming one or more electrically connected partitions (26) separating a first fluid (22) and a second fluid (24). The assembly (10) further comprises: a first electrical connector (14) and a second electrical connector (16) that are operationally connected to the partitions (26) of the heat exchanger (12) and an electrical power source (18) operationally connected to the first electrical connector (14) and the second electrical connector (16). The electrical power source (18) is configured to supply an electric current to the one or more partitions (26) of the heat exchanger (12) via the first electrical connector (14) and the second electrical connector (16).

Abstract: The present invention relates to a method for determining a desired speed of a vehicle (1), preferably an autonomous vehicle. The vehicle comprises a shock absorber arrangement (2), preferably an hydraulic shock absorber arrangement, having an elastic hysteresis. The method comprises—obtaining (501) a reference value indicative of the energy dissipated by the shock absorber arrangement (2) in a reference driving condition of a vehicle and—determining (502) a speed of the vehicle for which the value indicative of the energy dissipated by the shock absorber arrangement (2) in a similar driving condition is expected to fall within a predetermined energy dissipation range, using said reference value.

Abstract: A wheel hub drive system includes a drive motor with a drive shaft, an input planetary gear set (PGS), an output PGS and an intermediate PGS. Each PGS includes a sun gear, a planet carrier and planet gears provided upon the planet carrier. The drive shaft is rotationally fixed with the sun gear of the input PGS. The planet carrier of the input PGS is rotationally fixed with the sun gear of the intermediate PGS, and the planet carrier of the intermediate PGS is rotationally fixed with the sun gear of the output PGS. The planet carrier of the output PGS is adapted to be rotationally fixed with a rim of a wheel. The output PGS is provided axially in-between the input PGS and the intermediate PGS.

Abstract: The proposed technology relates to a system (8) for preventing microbiological growth in a conduit conveying a liquid. The system (8) comprises a multi-layered pipe (10) constituting said conduit and having an inner layer (12) that covers the complete inside (16) of the pipe (10) and is formed of an electrically conductive polymer material. A liquid in the pipe (10) is in direct contact with the inner layer (12). The system further has a first electrical connector (18) and a second electrical connector (19) connecting to the inner layer (12) from outside the pipe (10), wherein the first electric connector (18) and the second electric connector (19) are spaced apart along the pipe (10). The system further has an electric power source (20) operationally connected to the first electrical connector (18) and the second electrical connector (19) and configured for supplying an electric current to the inner layer (12).

Abstract: The present invention relates to a method for determining a functional status of a vehicle shock absorber arrangement (100). The method determines a difference between force values during compression and expansion of the vehicle shock absorber arrangement (100), whereby the shock absorber arrangement (100) can be determined to be degraded if the difference is below a predetermined threshold.

Abstract: A wheel hub arrangement for a driving wheel of a vehicle is provided. The wheel hub arrangement is provided with a planetary gear train including: a centrally arranged sun gear wheel fixed to a drive shaft that extends in an axial direction of the wheel hub arrangement; a set of planet gear wheels distributed circumferentially around and meshing with the sun gear wheel; a ring gear wheel member extending circumferentially around the planet gear wheels and being provided with a ring gear wheel meshing with the planet gear wheels; a stationary planet wheel carrier; an annular rolling-element bearing arranged between the ring gear wheel member and the planet wheel carrier, wherein the ring gear wheel member is configured to be fixed to the driving wheel of the vehicle.

Abstract: A wheel hub drive system includes a drive motor with a drive shaft, an input planetary gear set (PGS), an output PGS and an intermediate PGS. Each PGS includes a sun gear, a planet carrier and planet gears provided upon the planet carrier. The drive shaft is rotationally fixed with the sun gear of the input PGS. The planet carrier of the input PGS is rotationally fixed with the sun gear of the intermediate PGS, and the planet carrier of the intermediate PGS is rotationally fixed with the sun gear of the output PGS. The planet carrier of the output PGS is adapted to be rotationally fixed with a rim of a wheel. The output PGS is provided axially in-between the input PGS and the intermediate PGS.

Abstract: The present disclosure relates to pharmaceutical compositions suitable for oral administration, and more particularly to pharmaceutical compositions, including pharmaceutical tablet compositions, containing (2S)-N-{(1S)-1-cyano-2-[4-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide (Compound A) or a pharmaceutically acceptable salt thereof.