Patents by Inventor Thomas Andrew Wynn

Thomas Andrew Wynn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Naphthylenyl compounds for long-acting injectable compositions and related methods
    Patent number: 10799496
    Abstract: The present invention provides compounds useful for the treatment of opioid dependence, alcohol dependence, alcohol use disorder, or the prevention of relapse to opioid dependence in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: October 13, 2020
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Brian M. Aquila, Hoan Huynh, Lewis D. Pennington, Ingo Mugge, Baudouin Gerard, Markus Haeberlein, Roman A. Valiulin, Julius F. Remenar, Demetri T. Moustakas, Thomas Andrew Wynn, Todd Bosanac
  • Morphan and morphinan analogues, and methods of use
    Patent number: 10752592
    Abstract: The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: August 25, 2020
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Laura Cook Blumberg, Daniel R. Deaver, David J. Eyerman, Thomas Andrew Wynn
  • COMPOUNDS FOR THE TREATMENT OF PAIN
    Publication number: 20200255383
    Abstract: Provided herein are compounds that are useful in the treatment of pain in a subject.
    Type: Application
    Filed: February 13, 2020
    Publication date: August 13, 2020
    Inventors: Thomas Andrew Wynn, Juan C. Alvarez, Demetri Theodore Moustakas, Markus Haeberlein, Lewis D. Pennington
  • Methods for treating depressive symptoms
    Patent number: 10736890
    Abstract: The present application relates methods for treating a depressive symptom comprising administering an effective amount of a ? opioid receptor agonist or a pharmaceutically acceptable salt thereof to a subject in need thereof. Non-limiting examples of such agonist include the compounds of Formulas I, II, III, and IV, as well as the compounds of Table A.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: August 11, 2020
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Laura Cook Blumberg, Daniel R. Deaver, David J. Eyerman, Thomas Andrew Wynn
  • Compounds for the treatment of pain
    Patent number: 10604489
    Abstract: Provided herein are compounds that are useful in the treatment of pain in a subject.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: March 31, 2020
    Assignee: Alkermes, Inc.
    Inventors: Thomas Andrew Wynn, Juan C. Alvarez, Demetri Theodore Moustakas, Markus Haeberlein, Lewis D. Pennington
  • Prodrugs of fumarates and their use in treating various diseases
    Patent number: 10596140
    Abstract: The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: March 24, 2020
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Tarek A. Zeidan, Scott Duncan, Christopher P. Hencken, Thomas Andrew Wynn, Carlos N. Sanrame
  • Prodrugs of Fumarates and Their Use in Treating Various Diseases
    Publication number: 20200016111
    Abstract: The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.
    Type: Application
    Filed: July 29, 2019
    Publication date: January 16, 2020
    Inventors: Tarek A. Zeidan, Scott Duncan, Christopher P. Hencken, Thomas Andrew Wynn, Carlos N. Sanrame
  • NOVEL THIENOTHIOPHENE COMPOUNDS FOR LONG-ACTING INJECTABLE COMPOSITIONS AND RELATED METHODS
    Publication number: 20200017529
    Abstract: The present invention provides compounds useful for the treatment of opioid dependence, alcohol dependence, alcohol use disorder, or the prevention of relapse to opioid dependence in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.
    Type: Application
    Filed: July 11, 2019
    Publication date: January 16, 2020
    Inventors: Brian M. Aquila, Hoan Huynh, Lewis D. Pennington, Ingo Mugge, Baudouin Gerard, Markus Haeberlein, Roman A. Valiulin, Julius F. Remenar, Demetri T. Moustakas, Thomas Andrew Wynn, Todd Bosanac
  • NOVEL NAPHTHYLENYL COMPOUNDS FOR LONG-ACTING INJECTABLE COMPOSITIONS AND RELATED METHODS
    Publication number: 20200016151
    Abstract: The present invention provides compounds useful for the treatment of opioid dependence, alcohol dependence, alcohol use disorder, or the prevention of relapse to opioid dependence in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.
    Type: Application
    Filed: July 11, 2019
    Publication date: January 16, 2020
    Inventors: Brian M. Aquila, Hoan Huynh, Lewis D. Pennington, Ingo Mugge, Baudouin Gerard, Markus Haeberlein, Roman A. Valiulin, Julius F. Remenar, Demetri T. Moustakas, Thomas Andrew Wynn, Todd Bosanac
  • PRODRUGS OF FUMARATES AND THEIR USE IN TREATING VARIOUS DISEASES
    Publication number: 20190382413
    Abstract: The present invention provides compounds of formula (I), wherein: R1 is unsubstituted C1-C6 alkyl; La is substituted or unsubstituted C1-C6 alkyl linker, substituted or unsubstituted C3-C10 carbocycle, substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S, or substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S; and R2 and R3 are each, independently, H, substituted or unsubstituted C1-C6 alkyl, or substituted or unsubstituted C6-C10 aryl; or alternatively, R2 and R3, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S or a substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S.
    Type: Application
    Filed: December 17, 2018
    Publication date: December 19, 2019
    Inventors: Tarek A. Zeidan, Scott Duncan, Christopher P. Hencken, Thomas Andrew Wynn, Carlos N. Sanrame
  • Prodrugs of fumarates and their use in treating various diseases
    Patent number: 10406133
    Abstract: The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: September 10, 2019
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Tarek A. Zeidan, Scott Duncan, Christopher P. Hencken, Thomas Andrew Wynn, Carlos N. Sanrame
  • COMPOUNDS FOR THE TREATMENT OF PAIN
    Publication number: 20190241524
    Abstract: Provided herein are compounds that are useful in the treatment of pain in a subject.
    Type: Application
    Filed: February 4, 2019
    Publication date: August 8, 2019
    Inventors: Thomas Andrew Wynn, Juan C. Alvarez, Demetri Theodore Moustakas, Markus Haeberlein, Lewis D. Pennington
  • Morphan And Morphinan Analogues, And Methods Of Use
    Publication number: 20190218185
    Abstract: The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.
    Type: Application
    Filed: March 25, 2019
    Publication date: July 18, 2019
    Inventors: Laura Cook Blumberg, Daniel R. Deaver, David J. Eyerman, Thomas Andrew Wynn
  • PRODRUGS OF FUMARATES AND THEIR USE IN TREATING VARIOUS DISEASES
    Publication number: 20190201367
    Abstract: The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.
    Type: Application
    Filed: September 28, 2018
    Publication date: July 4, 2019
    Inventors: Tarek A. Zeidan, Scott Duncan, Christopher P. Hencken, Thomas Andrew Wynn, Carlos N. Sanrame
  • METHODS FOR TREATING DEPRESSIVE SYMPTOMS
    Publication number: 20190167666
    Abstract: The present application relates methods for treating a depressive symptom comprising administering an effective amount of a ? opioid receptor agonist or a pharmaceutically acceptable salt thereof to a subject in need thereof. Non-limiting examples of such agonist include the compounds of Formulas I, II, III, and IV, as well as the compounds of Table A.
    Type: Application
    Filed: February 11, 2019
    Publication date: June 6, 2019
    Inventors: Laura Cook Blumberg, Daniel R. Deaver, David J. Eyerman, Thomas Andrew Wynn
  • Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
    Patent number: 10301256
    Abstract: The present invention provides compounds and pharmaceutical compositions for treating neurological diseases such as multiple sclerosis.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: May 28, 2019
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Thomas Andrew Wynn, Christopher P. Hencken
  • Morphan and morphinan analogues, and methods of use
    Patent number: 10287250
    Abstract: The present application relates to analogs of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: May 14, 2019
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Laura Cook Blumberg, Daniel R. Deaver, David J. Eyerman, Thomas Andrew Wynn
  • Methods for treating depressive symptoms
    Patent number: 10231963
    Abstract: The present application relates methods for treating a depressive symptom comprising administering an effective amount of a ? opioid receptor agonist or a pharmaceutically acceptable salt thereof to a subject in need thereof. Non-limiting examples of such agonist include the compounds of Formulas I, II, III, and IV, as well as the compounds of Table A.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: March 19, 2019
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Laura Cook Blumberg, Daniel R. Deaver, David J. Eyerman, Thomas Andrew Wynn
  • Prodrugs of fumarates and their use in treating various diseases
    Patent number: 10189855
    Abstract: The present invention provides compounds of formula (I), wherein: R1 is unsubstituted C1-C6 alkyl; La is substituted or unsubstituted C1-C6 alkyl linker, substituted or unsubstituted C3-C10 carbocycle, substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S, or substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S; and R2 and R3 are each, independently, H, substituted or unsubstituted C1-C6 alkyl, or substituted or unsubstituted C6-C10 aryl; or alternatively, R2 and R3, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S or a substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: January 29, 2019
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Tarek A. Zeidan, Scott Duncan, Christopher P. Hencken, Thomas Andrew Wynn, Carlos N. Sanrame
  • Prodrugs of fumarates and their use in treating various diseases
    Patent number: 10117846
    Abstract: The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: November 6, 2018
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Tarek A. Zeidan, Scott Duncan, Christopher P. Hencken, Thomas Andrew Wynn, Carlos N. Sanrame