Patents by Inventor Thomas Antony James ADIE

Thomas Antony James ADIE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230357790
    Abstract: The present invention concerns new nucleic acid molecules which may be used in many applications, and methods for making the same. These nucleic acid molecules are preferably DNA vectors, optionally DNA expression vectors. The nucleic acid molecules are able to target the vector to a specific cellular location, such as the nucleus, due to the presence of one or more particular binding motifs within the nucleic acid molecule itself. Thus, the nucleic acid molecules of the invention may also be described as targeted delivery vectors, notably self-targeted delivery vectors or smart delivery vectors.
    Type: Application
    Filed: September 20, 2021
    Publication date: November 9, 2023
    Inventors: Paul James ROTHWELL, Michal LEGIEWICZ, Thomas Antony James ADIE, Leonor Maximo QUINTANEIRO
  • Publication number: 20220195415
    Abstract: The present invention concerns new artificially synthesized single stranded nucleic acid molecules which may be used in many applications, and templates and methods for making the same. There are a multitude of uses for single stranded nucleic acid molecules, including but not limited to vectors for the delivery of sequences (for example a gene sequence, or a template for gene editing, gene knock-in or knock-down) or in bioengineering, for example as for constructing highly ordered materials from nanoparticle building blocks.
    Type: Application
    Filed: April 23, 2020
    Publication date: June 23, 2022
    Inventors: Thomas Antony James ADIE, Paul James ROTHWELL, Michal LEGIEWICZ
  • Publication number: 20210301312
    Abstract: The present invention relates to an improved process for synthesis of deoxyribonucleic acid (DNA), in particular cell-free enzymatic synthesis of DNA, preferably on a large scale, with an improved yield and/or with an improved efficiency. The species of cation present in the nucleotide salt as the counter-ion is critical to the yield, efficiency and fidelity of high yielding enzymatic DNA synthesis reaction. The processes herein use alternative cations as counter-ions for the ionic nucleotides, permitting the use of higher concentrations of nucleotides in DNA synthesis, and further allowing for more favourable reaction conditions to be used.
    Type: Application
    Filed: August 16, 2019
    Publication date: September 30, 2021
    Inventors: Neil PORTER, Paul James ROTHWELL, Stefanie GEHRIG-GIANNINI, Anna BABULA, Thomas Antony James ADIE