Abstract: The current invention discloses a method for diagnosing Alzheimer disease by using biomarkers, and multivariate analysis which gives a more reliable, minimally- or non-invasive method of detection. The invention discloses simultaneous detection of CD69 protein in mitogenic lymphocytes, tau and phosphorylated tau proteins, and amyloid-? peptides in cerebrospinal fluid, which can replace or supplement conventional methods of detection of Alzheimer's disease such as cognitive testing and amyloid-positron emission tomography.

Abstract: Described are vectors containing (a) a gene encoding (i) a CDK4/CDK6 inhibitor, preferably p16INK4a, or (ii) an RNA interfering with CDK4 and/or CDK6 expression and/or activity, under the control of an inducible promoter and (b) a gene encoding a transactivator protein for said promoter useful for treating neurodegenerative disorders. These vectors can be transferred into cells where they will exert a protective function to (i) prevent cell death or to (ii) slow down progression of cell death. These vectors can be used in therapeutic applications to prevent neurodegenerative disorders or to slow down their progression with therapeutic efficacy.

Abstract: The invention relates to method for the diagnosis of Alzheimer's disease or the early stages thereof or a predisposition to said disease. Said method is based on quantitative determination of a mitogenically expressible surface marker, in particular CD69, and peripherally accessible cells, e.g. skin cells or lymphocytes, (a) prior to and (b) after mitogenic stimulation. A specific stimulation index a:b is an indication of Alzheimer's disease or early stages thereof or of a predisposition to said disease. The invention also relates to kits which are suitable for carrying out the inventive method of diagnosis.

Abstract: An implant carrier device for removable engagement with a dental implant includes a linear body member having first and second faceted exterior ends and an axial bore there through. A screw member having a head end and a threaded end is rotationally captured within the axial bore, with the threaded end extending exterior the second end of the carrier device. The threaded end of the screw member is adapted for rotational engagement of a threaded well within a dental implant. A dental implant engaged with both the faceted exterior second end of the linear body member and the threaded end of the captured screw member is partially driven into an osteotomy by way of the implant carrier device, followed by disengagement of the implant carrier device from the partially driven implant by rotation of the screw member captured within the axial bore of the implant carrier.

Abstract: A dispenser container assembly for storing and dispensing a medical/dental device comprises a support section, including first and second opposed clamshell halves pivoted together at a flexible hinge. Each clamshell half has a contact edge mating with a like contact edge of an opposed half to form a contained space therein. Each contact edge also has a feature mating with a like feature of an opposed contact edge to produce a mounting aperture for supporting a medical/dental device within the contained space. A cap section has a closed end and an open end that engages the support section to maintain the first and second opposed clamshell halves in a closed condition and to enclose an exterior portion of the medical/dental device supported in the mounting aperture of the support section.

Abstract: Described are vectors containing (a) a gene encoding (i) a CDK4/CDK6 inhibitor, preferably p16INK4a, or (ii) an RNA interfering with CDK4 and/or CDK6 expression and/or activity, under the control of an inducible promoter and (b) a gene encoding a transactivator protein for said promoter useful for treating neurodegenerative disorders. These vectors can be transferred into cells where they will exert a protective function to (i) prevent cell death or to (ii) slow down progression of cell death. These vectors can be used in therapeutic applications to prevent neurodegenerative disorders or to slow down their progression with therapeutic efficacy.

Abstract: An auto body decrimping tool assembly for decrimping a panel from a vehicle frame. The decrimping tool assembly includes a hollow housing body member with a first aperture at one end and a second aperture. A decrimping head member is pivotally mounted near an end thereof on a drive shaft member rotatably secured in the body member's second aperture. The decrimping head member includes a base portion having a protruding contact section and an opposed, protruding blade section having a concave, helical surface facing the contact section. The blade section includes a tapered edge at a side of the concave, helical surface opposite the base portion. The decrimping head member is mounted to the drive shaft member at the contact section. The decrimping head member is positioned at an edge of a panel crimped to the frame with the contact section on an edge of the crimped panel and the tapered edge of the blade section between the crimped panel and the frame.

Abstract: The invention relates to method for the diagnosis of Alzheimer's disease or the early stages thereof or a predisposition to said disease. Said method is based on quantitative determination of a mitogenically expressible surface marker, in particular CD69, and peripherally accessible cells, e.g. skin cells or lymphocytes, (a) prior to and (b) after mitogenic stimulation. A specific stimulation index a:b is an indication of Alzheimer's disease or early stages thereof or of a predisposition to said disease. The invention also relates to kits which are suitable for carrying out the inventive method of diagnosis.