Patents by Inventor Thomas B. Freeman

Thomas B. Freeman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190177420
    Abstract: The present invention relates to new humanized antagonistic anti-CD40 antibodies and therapeutic and diagnostic methods and compositions for using the same for treating and/or preventing lupus nephritis.
    Type: Application
    Filed: July 18, 2018
    Publication date: June 13, 2019
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Scott Ronald Brodeur, Thomas B. Freeman, Gerald Henery Nabozny, Meera Ramanujam, Paul Scholl, Juergen Steffgen
  • Patent number: 9968378
    Abstract: An improvement of a polyaxial screw head disclosed in the U.S. Pat. No. 8,277,490. A saddle resides within a tulip. The saddle is configured to mate with a rod. An outer set screw engages an inner surface of the tulip. An inner set screw is disposed within a lumen of an outer set screw. A force distributor has a concave surface configured to mate with the rod. The force distributor has a bore configured to accept a conical end of the inner set screw. The force distributor is configured to distribute the force applied onto the bore by the inner set screw along the contact area with rod. The force distributor allows the rod to pivot and have sagittal motion when the inner set screw is untightened. The force distributor immobilizes the rod within the saddle when the inner set screw is tightened.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: May 15, 2018
    Assignee: University of South Florida
    Inventors: Wesley M. Johnson, Thomas B. Freeman
  • Publication number: 20170058038
    Abstract: The present invention relates to new humanized antagonistic anti-CD40 antibodies and therapeutic and diagnostic methods and compositions for using the same for treating and/or preventing lupus nephritis.
    Type: Application
    Filed: August 31, 2016
    Publication date: March 2, 2017
    Inventors: Scott Ronald BRODEUR, Thomas B. FREEMAN, Gerald Henry NABOZNY, Meera RAMANUJAM, Paul SCHOLL, Juergen STEFFGEN
  • Patent number: 8734521
    Abstract: An inter-vertebral cage with a wedge shape eccentrically located on the leading end of the cage. The ectopically shaped leading edge of this embodiment facilitates easier interbody spacer placement with less risk of nerve injury, as well as with likely decreased risk of destruction of the end plate during the distraction process when the interbody cage is impacted.
    Type: Grant
    Filed: March 1, 2010
    Date of Patent: May 27, 2014
    Assignee: University of South Florida
    Inventors: Thomas B Freeman, Wesley Johnson
  • Patent number: 8579986
    Abstract: The present invention provides an apparatus and method that will allow surgeons to produce bone growth masses for use in spinal surgery that are capable of maintaining their physical integrity during placement and during the acute post operative period.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: November 12, 2013
    Assignee: University of South Florida
    Inventors: Thomas B. Freeman, Wesley M. Johnson, Ben Guiot
  • Patent number: 8540771
    Abstract: The present invention provides both a device and a method. The device is a human made replacement for the soft discs in the spine. A fabric pouch encloses a central hydraulic element made up of small soft beads. Two pouches with beads are implanted into a prepared disc space to function as an intervertebral disc. The method is conversion of the device into a fusion element.
    Type: Grant
    Filed: February 7, 2012
    Date of Patent: September 24, 2013
    Assignee: University of South Florida
    Inventors: Wesley M. Johnson, Thomas B. Freeman
  • Patent number: 8337829
    Abstract: The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferating cells in culture by contacting cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, non-fertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation.
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: December 25, 2012
    Assignees: University of South Florida, University of Chile
    Inventors: Thomas B. Freeman, Pablo Caviedes, Raul Caviedes
  • Patent number: 8277490
    Abstract: A novel surgical screw is presented as a polyaxial, multiaxial, or monoaxial screw. The polyaxial screw allows versatile angulation between a bone anchor section and a screw body and allows the surgeon to attach a rod to the invention in a top-loading manner and manipulate the rod to accommodate a patient's body and the surgical goals. The screw uses a rod saddle to seat a rod, and permits the surgeon to sagitally manipulate the rod. After implantation of the screw and insertion of the rod, a locking screw is used to fix the angle and position of the rod and screw body.
    Type: Grant
    Filed: March 1, 2010
    Date of Patent: October 2, 2012
    Assignee: University of South Florida
    Inventors: Thomas B. Freeman, Wesley M. Johnson
  • Patent number: 8252279
    Abstract: The subject invention pertains to materials and methods for inhibiting process formation and extension by cells in culture. The subject invention further includes cultures of process-forming cells wherein formation and extension of processes have been inhibited. In another aspect, the subject invention concerns methods of transplantation using process-forming cells that have been cultured by the process-inhibiting methods of the invention.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: August 28, 2012
    Assignee: University of South Florida
    Inventors: Pablo Caviedes, Raul Caviedes, Thomas B. Freeman, Juan A. Asenjo, Barbara A. Andrews, Dario SepĂșlveda, Christian Arriagada, Julio Salazar Rivera
  • Publication number: 20120148540
    Abstract: The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferating cells in culture by contacting cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, non-fertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation.
    Type: Application
    Filed: October 6, 2011
    Publication date: June 14, 2012
    Applicants: UNIVERSITY OF CHILE, UNIVERSITY OF SOUTH FLORIDA
    Inventors: THOMAS B. FREEMAN, Pablo Caviedes, Raul Caviedes, Paul R. Sanberg, Don F. Cameron
  • Publication number: 20120136447
    Abstract: The present invention provides both a device and a method. The device is a human made replacement for the soft discs in the spine. A fabric pouch encloses a central hydraulic element made up of small soft beads. Two pouches with beads are implanted into a prepared disc space to function as an intervertebral disc. The method is conversion of the device into a fusion element.
    Type: Application
    Filed: February 7, 2012
    Publication date: May 31, 2012
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Wesley M. Johnson, Thomas B. Freeman
  • Patent number: 8137662
    Abstract: The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferating cells in culture by containing cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, non-fertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: March 20, 2012
    Assignees: University of South Florida, University of Chile
    Inventors: Thomas B. Freeman, Pablo Caviedes, Raul Caviedes
  • Patent number: 8110003
    Abstract: The present invention provides both a device and a method. The device is a human made replacement for the soft discs in the spine. A fabric pouch encloses a central hydraulic element made up of small soft beads. Two pouches with beads are implanted into a prepared disc space to function as an intervertebral disc. The method is conversion of the device into a fusion element.
    Type: Grant
    Filed: September 9, 2005
    Date of Patent: February 7, 2012
    Assignee: University of South Florida
    Inventors: Wesley M. Johnson, Thomas B. Freeman
  • Patent number: 8012159
    Abstract: The present invention makes a grid array, for use in the transplantation of materials into the brain, in the shape of a predetermined structure, such as the putamen, based on anatomic analysis the structure. Alternatively, a smaller grid array is used which only includes the putamen target and not the caudate target, and also has two windows within the grid array. Because of the smaller size of this grid array as well as the two cutouts in the middle, it is possible for the first time to observe the brain as the needle enters the brain through the grid array. The previous solid and larger grid array made the passage of the needle into the brain a blind maneuver. Therefore if there was cortical bleeding at the time of needle insertion, it would not be known until after the transplant was done.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: September 6, 2011
    Assignee: University of South Florida
    Inventors: Thomas B. Freeman, James P. O'Connor
  • Patent number: 7981120
    Abstract: This document discusses trajectory guides that include an instrument guide with at least one lumen angled with respect to an orthogonal or other through-axis. In one example, patterned lumens on the instrument guide provide a mirror image pattern of trajectory axes intersecting a target plane. In another example, height adjustment of the instrument guide extends these or other targeting techniques to a three-dimensional volume. This document also describes a method of manufacturing such an instrument guide, which is also applicable to manufacturing an instrument guide providing parallel lumens.
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: July 19, 2011
    Assignee: University of South Florida
    Inventors: Rudy A. Mazzocchi, Matthew S. Solar, Thomas B. Freeman
  • Patent number: 7963980
    Abstract: An anti-subsidence, anti-translocation, fusion compression cervical plate system with interface visualization, drill guide and temporary pin is provided. In one embodiment the invention provides a vertebral plate for minimizing the ability of an inter-body cage, filled with bone (or BMP-soaked sponges, etc.), to telescope into the vertebral body and to minimize failure due to cages that telescope into adjacent vertebral bodies on a delayed basis after surgery, as well as creation of reverse lordosis due to such telescoping. Another embodiment provides method to reduce the gap between the inter-body cage and the vertebral body end plate intra-operatively using compression from the plate caused by an offset between the screw bores on the plate and the drill holes, as established with an asymmetric drill guide.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: June 21, 2011
    Assignee: University of South Florida
    Inventors: Thomas B. Freeman, Wesley Johnson
  • Patent number: 7896889
    Abstract: This document discusses trajectory guides that include an instrument guide with at least one lumen angled with respect to an orthogonal or other through-axis. In one example, patterned lumens on the instrument guide provide a mirror image pattern of trajectory axes intersecting a target plane. In another example, height adjustment of the instrument guide extends these or other targeting techniques to a three-dimensional volume. This document also describes a method of manufacturing such an instrument guide, which is also applicable to manufacturing an instrument guide providing parallel lumens.
    Type: Grant
    Filed: February 20, 2003
    Date of Patent: March 1, 2011
    Assignees: Medtronic, Inc., University of South Florida Research Foundation, Inc.
    Inventors: Rudy A. Mazzocchi, Matthew S. Solar, Thomas B. Freeman
  • Publication number: 20100234891
    Abstract: A novel surgical screw is presented as a polyaxial, multiaxial, or monoaxial screw. The polyaxial screw allows versatile angulation between a bone anchor section and a screw body and allows the surgeon to attach a rod to the invention in a top-loading manner and manipulate the rod to accommodate a patient's body and the surgical goals. The screw uses a rod saddle to seat a rod, and permits the surgeon to sagitally manipulate the rod. After implantation of the screw and insertion of the rod, a locking screw is used to fix the angle and position of the rod and screw body.
    Type: Application
    Filed: March 1, 2010
    Publication date: September 16, 2010
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Thomas B. Freeman, Wesley M. Johnson
  • Publication number: 20100179658
    Abstract: A intervertebral body device for supporting adjacent vertebrae includes a vertebral body member having at least one containment portion and one communicating portion. The containment portion and communication portion provide two distinct functional regions within the cage. One region of the cage provides for the use of a biologic material, and the region of the cage provides holes in the side or the front of the cage in order to allow bony ingrowth into that portion of the cage. Where numerous segments are needed, these components can be arranged in any combination.
    Type: Application
    Filed: March 24, 2010
    Publication date: July 15, 2010
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Thomas B. Freeman, Wesley M. Johnson
  • Publication number: 20100152857
    Abstract: An inter-vertebral cage with a wedge shape eccentrically located on the leading end of the cage. The ectopically shaped leading edge of this embodiment facilitates easier interbody spacer placement with less risk of nerve injury, as well as with likely decreased risk of destruction of the end plate during the distraction process when the interbody cage is impacted.
    Type: Application
    Filed: March 1, 2010
    Publication date: June 17, 2010
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Thomas B. Freeman, Wesley Johnson