Patents by Inventor Thomas B. Givens
Thomas B. Givens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6564153Abstract: A method is disclosed for predicting the presence of an abnormal level of one or more proteins in the clotting cascade from at least one time-dependent measurement profile. At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the abnormality and the set of predictor variables. Subsequently, the model is utilized to predict which protein or proteins in the clotting cascade are at an abnormal level, with the prediction being a more informative prediction than clot time alone.Type: GrantFiled: May 7, 2001Date of Patent: May 13, 2003Assignee: bioMerieuxInventors: Paul Braun, Thomas B. Givens, Timothy J. Fischer
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Publication number: 20020019706Abstract: A method is disclosed for predicting the presence of an abnormal level of one or more proteins in the clotting cascade from at least one time-dependent measurement profile. At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the abnormality and the set of predictor variables. Subsequently, the model is utilized to predict which protein or proteins in the clotting cascade are at an abnormal level, with the prediction being a better prediction than clot time alone.Type: ApplicationFiled: May 7, 2001Publication date: February 14, 2002Inventors: Paul Braun, Thomas B. Givens, Timothy J. Fischer
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Publication number: 20010053959Abstract: A method and apparatus are disclosed for predicting the presence of at least one congenital or acquired imbalance or therapeutic condition associated with thrombosis/hemostasis from at least one time-dependent measurement profile. At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the congenital or acquired imbalance or therapeutic condition, and the set of predictor variables. Subsequently, the model is utilized to predict the existence of the congenital or acquired imbalance or therapeutic condition in the unknown sample.Type: ApplicationFiled: July 30, 2001Publication date: December 20, 2001Inventors: Thomas B. Givens, Paul Braun, Timothy J. Fischer
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Patent number: 6321164Abstract: A method is disclosed for predicting the presence of an abnormal level of one or more proteins in the clotting cascade from at least one time-dependent measurement profile. At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the abnormality and the set of predictor variables. Subsequently, the model is utilized to predict which protein or proteins in the clotting cascade are at an abnormal level, with the prediction being a more informative prediction than clot time alone.Type: GrantFiled: December 31, 1997Date of Patent: November 20, 2001Assignee: Akzo Nobel N.V.Inventors: Paul Braun, Thomas B. Givens, Timothy J. Fischer
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Patent number: 6269313Abstract: A method and apparatus are disclosed for predicting the presence of at least one congenital or acquired imbalance or therapeutic condition associated with thrombosis/hemostasis from at least one time-dependent measurement profile. At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the congenital or acquired imbalance or therapeutic condition, and the set of predictor variables. Subsequently, the model is utilized to predict the existence of the congenital or acquired imbalance or therapeutic condition in the unknown sample.Type: GrantFiled: March 2, 2000Date of Patent: July 31, 2001Assignee: Akzo Nobel N.V.Inventors: Thomas B. Givens, Paul Braun, Timothy J. Fischer
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Patent number: 6101449Abstract: A method and apparatus are disclosed for predicting the presence of at least one congenital or acquired imbalances or therapeutic condition associated with thrombosis/hemostasis from at least one time-dependent measurement profile. At least one time-dependent measurement in a sample is performed and a respective property of sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the congenital or acquired imbalance or therapeutic condition, and the set of predictor variables. Subsequently, the model is utilized to predict the existence of the congenital or acquired imbalance or therapeutic condition in a sample.Type: GrantFiled: May 21, 1997Date of Patent: August 8, 2000Assignee: Akzo Nobel N.V.Inventors: Thomas B. Givens, Paul Braun, Timothy J. Fischer
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Patent number: 5708591Abstract: A method and apparatus are disclosed for predicting the presence of at least one congenital or acquired imbalance or therapeutic condition associated with thrombosis/hemostasis from at least one time-dependent measurement profile. At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the congenital or acquired imbalance or therapeutic condition, and the set of predictor variables. Subsequently, the model is utilized to predict the existence of the congenital or acquired imbalance or therapeutic condition in the unknown sample.Type: GrantFiled: June 7, 1995Date of Patent: January 13, 1998Assignee: Akzo Nobel N.V.Inventors: Thomas B. Givens, Paul Braun, Timothy J. Fischer
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Patent number: 5456884Abstract: A mechanism is provided for loading the cassette into an operative relationship with a machine for dispensing contents of the cassette for use by the machine. The loading mechanism includes a base adapted for being fixedly mounted on the machine. The loading mechanism also includes a holder for releasably holding the cassette. The holder has one end pivotally connected to the base for pivoting about an axis for moving the cassette between a first position at which the holder releasably receives the cassette and a second position at which the cassette is placed in an operative relationship with the machine. The loading mechanism further includes a linkage mechanism coupled between the base and the holder for translating the holder along the axis as the holder is pivoted between the first and second positions.Type: GrantFiled: June 14, 1994Date of Patent: October 10, 1995Assignee: Akzo Nobel N.V.Inventors: Gregory D. Lewis, Roger G. Roberts, Thomas B. Givens
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Patent number: 5364592Abstract: A cassette for storing and dispensing cuvettes and comprising an enclosable frame defining an interior volume for storing cuvettes. The frame includes a removable cover to aid in loading a plurality of cuvettes into the cassette. The frame also includes a side wall having a pivotally mounted door for pivoting between a closed position and an open position for dispensing the cuvettes from the cassette. And, the frame includes a locking mechanism for locking the door in the closed position to avoid an inadvertent dispensing of cuvettes. According to another aspect of the invention, a mechanism is provided for loading the cassette into an operative relationship with a machine for dispensing contents of the cassette for use by the machine. The loading mechanism includes a base adapted for being fixedly mounted on the machine. The loading mechanism also includes a holder for releasably holding the cassette.Type: GrantFiled: July 22, 1992Date of Patent: November 15, 1994Assignee: Akzo N.V.Inventors: Gregory D. Lewis, Roger G. Roberts, Thomas B. Givens
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Patent number: 5040894Abstract: A cuvette for use in an optical instrument which includes a linear drive mechanism formed of a lead screw for positioning the cuvette along a linear path in the instrument. The cuvette has a body including at least one reaction well and an engaging feature for operatively engaging the threads of the lead screw so that the cuvette can be positioned along the linear path of the instrument. Preferably the reaction well of the cuvette has a trapezoid-shape cross section in a plane parallel to the optical path of the instrument in order to maximize the optical viewing area.Type: GrantFiled: December 1, 1989Date of Patent: August 20, 1991Assignee: Akzo N.V.Inventors: Joseph G. Karp, Thomas B. Givens, John G. Link
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Patent number: 4705035Abstract: A parallax-free optical zone marker for use in radial karatotomy cornea surgery for impressing a temporary circular indentation into the cornea, the circular indentation to be used as a reference for radial incisions therefrom. The marker, integrally molded, includes an elongated handle and a collar portion disposed at one end of the handle. The lower end margin of the collar is preferrably circular an adapted to impress the circular indentation into the cornea with normal hand pressure applied through the handle. A passageway extends through the collar from its upper end margin to its lower end margin. Disposed within the passageway are a pair of crossplanes intersecting, preferably at ninety degrees one to another, along the longitudinal axis of the passageway, which axis intersects the center of the circular lower end margin.Type: GrantFiled: September 2, 1986Date of Patent: November 10, 1987Assignee: Visitec CompanyInventor: Thomas B. Givens
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Patent number: D325090Type: GrantFiled: November 30, 1989Date of Patent: March 31, 1992Assignee: Akzo N.V.Inventors: Joseph G. Karp, Thomas B. Givens, John Link