Abstract: A method for cleaning primary packaging means in pharmaceutical filling and/or packaging installations. The method includes a step of treating at least one surface of the primary packaging by means of blasting with carbon dioxide (CO2) snow, a step of using a gas flow for the suction extraction of substances cleaned off from the surface, and a step of filtering the gas flow comprising the substances contained in the cleaned-off substances. A related system includes a supply device for supplying liquid CO2 and compressed air to at least one nozzle designed to generate solid particles by means of expanding the liquid CO2 to be directed onto a surface to be treated, a holding device for primary packaging, a substance removal device to remove substances cleaned from at least one surface by means of a gas flow; and a filter device for the gas flow comprising the cleaned substances.

Abstract: A frame structure is adapted to absorb energy from frontal impacts and extends under a front portion of the body frame. The frame structure includes a rear sub-frame located below and in front of a pair of side frame under-members, and at least one ramp connected to the pair of side frame under-members for directing rearward sliding movement of the rear sub-frame and attached structures downwardly beneath a battery assembly. A catching surface engages a steering gear to improve energy absorption during frontal impacts. A reinforcement bracket attached to the pair of side frame under-members defines a pocket for temporarily catching the rear sub-frame providing an energy absorption path before releasing the rear sub-frame to slide past. A tether is connected between the pair of side frame under-members and the rear sub-frame for holding the rear sub-frame against the ramp to increase energy absorption.

Abstract: A vehicle frame includes an inverter protection brace extending between front and rear sub-frames located below and in front of side under frame members. A gusset of the brace strongly connects to the front sub-frame to load a beam section without overloading attaching bolts. The brace has a bolted connection attaches to the rear sub-frame. The brace deforms forward of the bolted connection creating a safety cage around an inverter during frontal impacts. A reinforcement bracket attaches to the side frame under members to define a pocket for temporarily catching the rear sub-frame. Ramps connect to the reinforcement bracket allowing sliding of the rear sub-frame rearward, and direct movement downwardly beneath a battery assembly. A catching surface defined on the ramp engages at least one rear sub-frame attached structure. A tether connects between the pair of side frame under-members and the rear sub-frame for improving the interaction of the rear sub-frame against the ramps.

Abstract: A frame structure is adapted to absorb energy from frontal impacts and extends under a front portion of the body frame. The frame structure includes a rear sub-frame located below and in front of a pair of side frame under-members, and at least one ramp connected to the pair of side frame under-members for directing rearward sliding movement of the rear sub-frame and attached structures downwardly beneath a battery assembly. A catching surface engages a steering gear to improve energy absorption during frontal impacts. A reinforcement bracket attached to the pair of side frame under-members defines a pocket for temporarily catching the rear sub-frame providing an energy absorption path before releasing the rear sub-frame to slide past. A tether is connected between the pair of side frame under-members and the rear sub-frame for holding the rear sub-frame against the ramp to increase energy absorption.

Abstract: A frame structure absorbs energy from frontal impacts and extends under a front portion of the body frame. The frame structure includes a rear sub-frame located below and in front of a pair of side frame under-members, and an inverter protection brace extending between the front sub-frame and the rear sub-frame. Loading from the inverter protection brace travels through the rear sub-frame to A-point bolt connections located on the pair of front frame side members. The rear sub-frame moves rearward and deforms at the A-point bolt connections. The load through the A-point bolt connections changes the deformation mode of the frame front side members between the A-point bolt connections and B-point bolt connections. At least one of the pair of side frame under-members buckles rearward of the B-point bolt connection located on the pair of side frame under-members for energy absorption during the frontal impact.

Abstract: A vehicle frame includes an inverter protection brace extending between front and rear sub-frames located below and in front of side frame members. A gusset of the brace strongly connects to the front sub-frame to load a beam section without overloading the bolts, and a bolted connection attaches to the rear sub-frame. The brace deforms forward of the bolted connection creating a safety cage around an inverter during frontal impacts. A reinforcement bracket attaches to the side frame members to define a pocket for temporarily catching the rear sub-frame. Ramps connect to the reinforcement bracket allowing sliding of the rear sub-frame rearward, and direct movement downwardly beneath a battery assembly. A catching surface defined on a ramp engages at least one rear sub-frame attached structure. A tether connects between the pair of side frame under-members and the rear sub-frame for improving the interaction of the rear sub-frame against the ramps.

Abstract: A frame structure absorbs energy from frontal impacts and extends under a front portion of the body frame. The frame structure includes a rear sub-frame located below and in front of a pair of side frame under-members, and an inverter protection brace extending between the front sub-frame and the rear sub-frame. Loading from the inverter protection brace travels through the rear sub-frame to A-point bolt connections located on the pair of front frame side members. The rear sub-frame moves rearward and deforms at the A-point bolt connections. The load through the A-point bolt connections changes the deformation mode of the frame front side members between the A-point bolt connections and B-point bolt connections. At least one of the pair of side frame under-members buckles rearward of the B-point bolt connection located on the pair of side frame under-members for energy absorption during the frontal impact.

Abstract: The invention provides improvements in the field of animal models for testing effects of genes introduced into animal cells or tissue by adenoviral gene transfer. More particularly the invention provides a plasmid construct that expresses a porcine adenovirus receptor (pCAR) and transgenic animals that show expression of pCAR.