Patents by Inventor Thomas B. K. Lee

Thomas B. K. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preparation of isopropyl 4,10-dihydro-10-oxothieno[3,2-c][1]benzoxepin-8-acetate
    Patent number: 4211877
    Abstract: Isopropyl 4,10-dihydro-10-oxothieno[3,2-c][1]benzoxepin-8-acetate is synthesized from 4-(2-carboxy-3-thienylmethoxy)phenylacetic acid by a process comprising acid halide formation, ring closure catalyzed by aluminum trihalide and esterification with isopropyl alcohol. The three reaction steps are carried out successively in the same reactor without any isolation or purification of intermediate products and a surprisingly high overall yield is obtained. Additionally, a valuable chemical, aluminum isopropoxide is obtained as a by-product of this process and significant advantages in terms of environmental pollution and waste water costs are achieved.
    Type: Grant
    Filed: February 13, 1979
    Date of Patent: July 8, 1980
    Assignee: American Hoechst Corporation
    Inventor: Thomas B. K. Lee
  • Preparation of 6,11-dihydro-11-oxodibenz[b,e]-oxepin-2-acetic acid and precursors therefor
    Patent number: 4175209
    Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
    Type: Grant
    Filed: September 5, 1978
    Date of Patent: November 20, 1979
    Assignee: American Hoechst Corporation
    Inventors: Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee
  • 4-Benzyloxy-3-(chlorocarbonyl)-phenylacetyl chloride
    Patent number: 4160781
    Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
    Type: Grant
    Filed: September 5, 1978
    Date of Patent: July 10, 1979
    Assignee: American Hoechst Corporation
    Inventors: Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee
  • 4-Benzyloxy-3-(benzyloxy carbonyl)phenylthioacetmorpholide
    Patent number: 4153790
    Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
    Type: Grant
    Filed: September 5, 1978
    Date of Patent: May 8, 1979
    Assignee: American Hoechst Corporation
    Inventors: Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee
  • 3-Carboxy-4 hydroxyphenylthioacetmorpholide
    Patent number: 4153791
    Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
    Type: Grant
    Filed: September 5, 1978
    Date of Patent: May 8, 1979
    Assignee: American Hoechst Corporation
    Inventors: Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee
  • Preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid and precursors therefor
    Patent number: 4118401
    Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
    Type: Grant
    Filed: October 19, 1977
    Date of Patent: October 3, 1978
    Assignee: American Hoechst Corporation
    Inventors: Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee