Patents by Inventor Thomas B Mathie

Thomas B Mathie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • inFB
    Patent number: 6399343
    Abstract: The invention provides infB polypeptides and polynucleotides encoding infB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing in polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: June 4, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, Richard Lloyd Warren, Magdalena Zalacain, Chi Young So, Christopher M Traini, David John Holmes, Karen Anne Ingraham, Thomas B Mathie
  • trmD
    Patent number: 6350600
    Abstract: The invention provides trmA methyl transferase (trmD) polypeptides and polynucleotides encoding trmD polypeptides and methods for producing such polypeptides by recominant techniques from strepococcus pneumoniae. Also provided are methods for utilizing polypepides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: February 26, 2002
    Assignee: SmithKline Beecham Corp.
    Inventors: Sanjoy Biswas, James Raymond Brown, Chi Young So, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Thomas B Mathie, Richard Lloyd Warren, Magdalena Zalacain
  • Respiratory nitrate reductase alpha subunit
    Patent number: 6316237
    Abstract: The invention provides respiratory nitrate reductase alpha subunit polypeptides and polynucleotides encoding respiratory nitrate reductase alpha subunit polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing respiratory nitrate reductase alpha subunit polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: November 13, 2001
    Assignee: SmithKline Beecham Corp.
    Inventors: Thomas B Mathie, Christopher M Traini, Stephanie Van Horn, Richard L Warren
  • Isolated nucleic acid encoding nucleotide pyrophosphorylase
    Patent number: 6268177
    Abstract: The invention provides ndp polypeptides and polynucleotides encoding ndp polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ndp polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: July 31, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Thomas B Mathie, Richard Lloyd Warren, Magdalena Zalacain
  • murF2
    Patent number: 6225457
    Abstract: The invention provides murF2 polypeptides and polynucleotides encoding murF2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing murF2 polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: May 1, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin K R Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Thomas B Mathie, Richard Lloyd Warren, Magdalena Zalacain
  • Polynucleotides encoding tRNA methyl transferases from Streptococcus pneumoniae
    Patent number: 6165764
    Abstract: The invention provides tRNA methyl transferase (trmD) polypeptides and polynucleotides encoding trmD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing trmD polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 23, 1999
    Date of Patent: December 26, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: David John Holmes, Karen Anne Ingraham, Thomas B Mathie, Richard Lloyd Warren, Magdalena Zalacain, Sanjoy Biswas, James Raymond Brown, Chi Young So, Alison Francis Chalker
  • Respiratory nitrate reductase alpha subunit
    Patent number: 6117662
    Abstract: The invention provides respiratory nitrate reductase alpha subunit polypeptides and polynucleotides encoding respiratory nitrate reductase alpha subunit polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing respiratory nitrate reductase alpha subunit polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 12, 1999
    Date of Patent: September 12, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Thomas B Mathie, Christopher M Traini, Stephanie Van Horn, Richard L Warren
  • infB
    Patent number: 6110685
    Abstract: The invention provides infB polypeptides and polynucleotides encoding in polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing infB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 1, 1999
    Date of Patent: August 29, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, Richard Lloyd Warren, Magdalena Zalacain, Chi Young So, Christopher M Traini, David John Holmes, Karen Anne Ingraham, Thomas B Mathie