Patents by Inventor Thomas B. Nutman

Thomas B. Nutman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIOMARKERS AND IMMUNOGENIC COMPOSITIONS FOR FILARIAL PARASITES
    Publication number: 20230414731
    Abstract: Disclosed herein are immunogenic compositions for preventing or treating infection with filarial parasites and biomarkers for diagnosing infection with filarial parasites.
    Type: Application
    Filed: February 23, 2023
    Publication date: December 28, 2023
    Inventors: Sara Lustigman, Thomas B. Nutman, Sasisekhar Bennuru
  • COMPOSITIONS AND METHODS FOR PREVENTING AND/OR TREATING FILARIAL DISEASE
    Publication number: 20210220333
    Abstract: The present disclosure is directed to methods for preventing or treating helminth (e.g., filarial) diseases in animals. The methods are accomplished by administering to the animal a therapeutically effective amount of an inhibitor of UDP-glucoronosyl transferase (UGT) or immunoglobulin I-set domain containing protein (Igl-DCP, also known as BMA-Lad-2). The inhibitors include those known to inhibit glucuronyltransferase enzyme activity as well as cell adhesion molecule inhibitors and antibodies specific for Igl-DCP and/or UGT.
    Type: Application
    Filed: September 6, 2019
    Publication date: July 22, 2021
    Inventors: Edward Elias Saul MITRE, Christopher Paul MORRIS, Alexander Francis FLYNN, Thomas B. NUTMAN, Sasisekhar BENNURU
  • BIOMARKERS AND IMMUNOGENIC COMPOSITIONS FOR FILARIAL PARASITES
    Publication number: 20210046170
    Abstract: Disclosed herein are immunogenic compositions for preventing or treating infection with filarial parasites and biomarkers for diagnosing infection with filarial parasites.
    Type: Application
    Filed: October 21, 2020
    Publication date: February 18, 2021
    Inventors: Sara Lustigman, Thomas B. Nutman, Sasisekhar Bennuru
  • Compositions and methods for detecting
    Patent number: 10598655
    Abstract: Disclosed are methods of detecting the presence of Loa loa in a biological sample using one or more antigens, each having a different amino acid sequence selected from the group consisting of SEQ ID NOs: 1-20. Related compositions, specific binding partners, and test kits are also disclosed.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: March 24, 2020
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Thomas B. Nutman, Sasisekhar Bennuru, Papa Makhktar Drame
  • BIOMARKERS AND IMMUNOGENIC COMPOSITIONS FOR FILARIAL PARASITES
    Publication number: 20190142916
    Abstract: Disclosed herein are immunogenic compositions for preventing or treating infection with filarial parasites and biomarkers for diagnosing infection with filarial parasites.
    Type: Application
    Filed: March 31, 2017
    Publication date: May 16, 2019
    Inventors: Sara Lustigman, Thomas B. Nutman, Sasisekhar Bennuru
  • COMPOSITIONS AND METHODS FOR DETECTING LOA LOA
    Publication number: 20180209967
    Abstract: Disclosed are methods of detecting the presence of detecting the presence of Loa loa in a biological sample using one or more antigens, each having a different amino acid sequence selected from the group consisting of SEQ ID NOs: 1-20. Related compositions, specific binding partners, and test kits are also disclosed.
    Type: Application
    Filed: April 28, 2016
    Publication date: July 26, 2018
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Service
    Inventors: Thomas B. Nutman, Sasisekhar Bennuru, Papa Makhktar Drame
  • Diagnostic assays and methods of use for detection of filarial infection
    Patent number: 9068993
    Abstract: The polynucleotide encoding the antigen Wb123 from the filarial nematode Wuchereria bancrofti, the major causative organism of lymphatic filariasis is provided, along with the polypeptide encoded by the polynucleotide. Methods for making the WM23 antigen, recombinant vectors encoding the Wb123 polynucleotide, and methods of detection of the Wb123 antigen through luciferase immunoprecipitation, ELISA and other detection systems are also provided.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: June 30, 2015
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Thomas B. Nutman, Doran Fink, Joseph Kubofcik, Peter D. Burbelo
  • Vaccine and methods of use against infection
    Patent number: 9056068
    Abstract: The polynucleotide encoding the SSIR gene from the nematode Strongyloides stercoralis is provided, along with the polypeptide encoded by the SSIR gene. It was found that when mice were immunized with the SSIR polypeptide vaccine, it provided immunity to mice which were implanted with Strongyloides stercoralis L3 implants. Methods for making the SSIR protein, recombinant vectors encoding the SSIR gene, a vaccine made from the SSIR protein, and methods of use are also provided.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: June 16, 2015
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Thomas Jefferson University
    Inventors: Thomas B. Nutman, David Abraham
  • DIAGNOSTIC ASSAYS AND METHODS OF USE FOR DETECTION OF FILARIAL INFECTION
    Publication number: 20130273111
    Abstract: The polynucleotide encoding the antigen Wb123 from the filarial nematode Wuchereria bancrofti, the major causative organism of lymphatic filariasis is provided, along with the polypeptide encoded by the polynucleotide. Methods for making the WM23 antigen, recombinant vectors encoding the Wb123 polynucleotide, and methods of detection of the Wb123 antigen through luciferase immunprecipitation, ELISA and other detection systems are also provided.
    Type: Application
    Filed: October 31, 2011
    Publication date: October 17, 2013
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Thomas B. Nutman, Doran Fink, Joseph Kubofcik, Peter D. Burbelo
  • VACCINE AND METHODS OF USE AGAINST STRONGYLOIDES STERCORALIS INFECTION
    Publication number: 20120308599
    Abstract: The polynucleotide encoding the SSIR gene from the nematode Strongyloides stercoralis is provided, along with the polypeptide encoded by the SSIR gene. It was found that when mice were immunized with the SSIR polypeptide vaccine, it provided immunity to mice which were implanted with Strongyloides stercoralis L3 implants. Methods for making the SSIR protein, recombinant vectors encoding the SSIR gene, a vaccine made from the SSIR protein, and methods of use are also provided.
    Type: Application
    Filed: February 1, 2011
    Publication date: December 6, 2012
    Applicants: Thomas Jefferson University, Health and Human Services
    Inventors: Thomas B. Nutman, David Abraham
  • Nucleotide molecule encoding a specific Onchocerca volvulus antigen for the immunodiagnosis of onchocerciasis
    Patent number: 5416009
    Abstract: The present invention relates to a DNA segment encoding an Onchocerca volvulus antigen: a specific and early marker of onchocerciasis infection. The nvention further relates to recombinant molecules containing such a segment and to methods of utilizing same to produce the Onchocerca volvulus antigen. The invention also relates to the antigen itself. The invention further relates to methods of diagnosing Onchocerciasis infection.
    Type: Grant
    Filed: January 23, 1991
    Date of Patent: May 16, 1995
    Assignee: The United States of America
    Inventors: Mario E. S. L. Lazzeri, Thomas B. Nutman, Niklaus Weiss