Patents by Inventor Thomas B.o slashed.rglum Kjeldsen

Thomas B.o slashed.rglum Kjeldsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic leader peptide sequences
    Patent number: 5795746
    Abstract: The present invention relates to a DNA expression cassette comprising the following sequence:5'-P-SP-LS-PS-*gene*-(T).sub.i -3'whereinP is a promoter sequence,SP is a DNA sequence encoding a signal peptide,LS is a DNA sequence encoding a leader peptide of formula I:GlnProIle(Asp/Glu)(Asp/Glu)X.sup.1 (Glu/Asp)X.sup.2 AsnZ(Thr/Ser)X.sup.3 (SEQ ID NO:77) (I)whereinX.sup.l is a peptide bond or a codable amino acid;X.sup.2 is a peptide bond, a codable amino acid or a sequence of up to 4 codable amino acids which may be the same or different;Z is a codable amino acid except Pro; andX.sup.3 is a sequence of from 4 to 30 codable amino acids which may be the same or different;PS is a DNA sequence encoding a processing site;*gene* is a DNA sequence encoding a polypeptide;T is a terminator sequence; andi is 0 or 1.
    Type: Grant
    Filed: January 8, 1997
    Date of Patent: August 18, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Thomas B.o slashed.rglum Kjeldsen, Knud Vad
  • Synthetic leader peptide sequences
    Patent number: 5639642
    Abstract: The present invention relates to a DNA expression cassette comprising the following sequence:5'-P-SP-LS-PS-*gene*-(T).sub.i -3'whereinP is a promoter sequence,SP is a DNA sequence encoding a signal peptide,LS is a DNA sequence encoding a leader peptide of formula I:GinProIle(Asp/Glu)(Asp/Glu)X.sup.1 (Glu/Asp)X.sup.2 AsnZ(Thr/Ser)X.sup.3 (SEQ ID NO: 77) (I)whereinX.sup.1 is a peptide bond or a codable amino acid;X.sup.2 is a peptide bond, a codable amino acid or a sequence of up to 4 codable amino acids which may be the same or different;Z is a codable amino acid except Pro; andX.sup.3 is a sequence of from 4 to 30 codable amino acids which may be the same or different;PS is a DNA sequence encoding a processing site;*gene* is a DNA sequence encoding a polypeptide;T is a terminator sequence; andi is 0 or 1.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 17, 1997
    Assignee: Novo Nordisk A/S
    Inventors: Thomas B.o slashed.rglum Kjeldsen, Knud Vad