Patents by Inventor Thomas B. Ottoboni

Thomas B. Ottoboni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF IMAGING LYMPHATIC SYSTEM USING NANOCAPSULE COMPOSITIONS
    Publication number: 20080319320
    Abstract: A composition is provided accompanying nanoparticles having diameters in the range of about 100 to 800 nanometers with hollow cores and outer shells with mechanical properties such that they rupture on exposure to predetermined ultrasound energy. The composition is useful for identifying sentinel lymph nodes.
    Type: Application
    Filed: August 20, 2008
    Publication date: December 25, 2008
    Applicant: Point Biomedical Corporation
    Inventors: Thomas B. Ottoboni, Robert E. Short, Jeffrey D. Gabe
  • NANOBUBBLES USEFUL AS AN ULTRASONIC CONTRAST AGENT FOR THE LYMPHATIC SYSTEM
    Publication number: 20080181853
    Abstract: A composition is provided accompanying nanoparticles having diameters in the range of about 100 to 800 nanometers with hollow cores and outer shells with mechanical properties such that they rupture on exposure to predetermined ultrasound energy. The composition is useful for identifying sentinel lymph nodes.
    Type: Application
    Filed: July 20, 2007
    Publication date: July 31, 2008
    Applicant: POINT BIOMEDICAL CORPORATION
    Inventors: Thomas B. Ottoboni, Robert E. Short, Jeffrey D. Gabe
  • Method for ultrasound triggered drug delivery using hollow microbubbles with controlled fragility
    Patent number: 6896659
    Abstract: A method is provided for site specific delivering therapeutic or diagnostic agents to a region in a fluid-filled cavity, vessel or tissue using an agent-loaded microbubble population. The population has controlled fragility characterized by a uniform wall thickness to diameter ratio which defines the discrete threshold intensity value of ultrasonic power where microbubble rupture occurs in the population. The location of the microbubble population may be monitored by ultrasound to determine its presence at the region prior to application of the ultrasonic power to rupture to microbubbles.
    Type: Grant
    Filed: October 22, 2001
    Date of Patent: May 24, 2005
    Assignee: Point Biomedical Corporation
    Inventors: Stanley R. Conston, Ronald Yamamoto, Thomas B. Ottoboni, E. Glenn Tickner
  • Method of preparing gas-filled polymer matrix microparticles useful for delivering drug
    Publication number: 20040185108
    Abstract: A method is provided to prepare drug containing gas-filled porous microparticles having a polymer matrix interior which are useful for ultrasound mediated targeted delivery of a drug. An oil-in-water suspension is formed, both phases are frozen, then the aqueous and nonaqueous frozen phases are removed by sublimation.
    Type: Application
    Filed: March 18, 2003
    Publication date: September 23, 2004
    Inventors: Robert E. Short, Thomas B. Ottoboni
  • Hollow microspheres with controlled fragility for medical use
    Patent number: 6776761
    Abstract: A composition for ultrasonic imaging is described having a microbubble population of controlled fragility. The microbubbles comprise an outer shell and a hollow core. The ratio of shell thickness to microbubble diameter is substantially similar across the population of microbubbles. A method of using such composition for imaging a fluid filled cavity, vessel or tissue is described.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: August 17, 2004
    Assignee: Point Biomedical Corporation
    Inventors: Thomas B. Ottoboni, E. Glenn Tickner, Robert E. Short, Ronald K. Yamamoto
  • Microparticles useful as ultrasonic contrast agents
    Publication number: 20040086459
    Abstract: Microparticles are provided comprising a shell of an outer layer of a biologically compatible material and an inner layer of biodegradable polymer. The core of the microparticles contain a gas, liquid or solid for use in drug delivery or as a contrast agent for ultrasonic contrast imaging. The microparticles are capable of passing through the capillary systems of a subject.
    Type: Application
    Filed: October 20, 2003
    Publication date: May 6, 2004
    Inventors: Thomas B. Ottoboni, Robert E. Short, Ronald K. Yamamoto
  • Microparticles having a matrix interior useful for ultrasound triggered delivery of drugs into the bloodstream
    Publication number: 20030215394
    Abstract: A microparticle composition is provided for delivery of a pharmaceutical agent by ultrasound triggering. The microparticles have a porous, gas-containing interior polymer matrix and a plurality of cavities in the matrix which contain a gas and the agent. Methods for forming the microparticles and their use in ultrasonic diagnostic imaging and drug delivery are also provided.
    Type: Application
    Filed: May 17, 2002
    Publication date: November 20, 2003
    Inventors: Robert E. Short, Thomas B. Ottoboni, Matthew B. Kerby
  • Intravesical drug delivery system
    Patent number: 6524608
    Abstract: Bioerodible, sustained release preparations are provided for placement into the bladder through the urethra which provided sustained release of drugs. Configurations are provided which are insertable through a catheter, such as a coiled filament, patch or a flowable gel. The device is bioeroded during or after the sustained release of the drug such that there is no blockage of the urinary tract while the device is in place within the bladder.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: February 25, 2003
    Assignee: Point Biomedical Corporation
    Inventors: Thomas B. Ottoboni, Ronald K. Yamamoto, Stanley R. Conston
  • Hollow microspheres with controlled fragility for medical use
    Publication number: 20030036697
    Abstract: A composition for ultrasonic imaging is described having a microparticle population of controlled fragility. A method of using such composition for imaging a fluid filled cavity, vessel or tissue is described.
    Type: Application
    Filed: August 20, 2002
    Publication date: February 20, 2003
    Inventors: Thomas B. Ottoboni, E. Glenn Tickner, Robert E. Short, Ronald K. Yamamoto
  • Excipient for the lyophilization of aqueous suspensions of microparticles
    Patent number: 6482518
    Abstract: An excipient for lyophilizing a suspension of microparticles is provided comprising an oil-in-water emulsion of an aqueous phase and an organic phase where the organic phase has a freezing point of about or higher than the freezing point of the aqueous phase. When frozen and dried with a suspension of microparticles, the organic phase is substantially removed and a dry formulation is formed of discrete microparticles substantially free of aggregates.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: November 19, 2002
    Assignee: Point Biomedical Corporation
    Inventors: Robert E. Short, Thomas B. Ottoboni
  • Method for ultrasound triggered drug delivery using hollow microbubbles with controlled fragility
    Publication number: 20020151792
    Abstract: A method is provided for site specific delivering therapeutic or diagnostic agents to a region in a fluid-filled cavity, vessel or tissue using an agent-loaded microbubble population. The population has controlled fragility characterized by a uniform wall thickness to diameter ratio which defines the discrete threshold intensity value of ultrasonic power where microbubble rupture occurs in the population. The location of the microbubble population may be monitored by ultrasound to determine its presence at the region prior to application of the ultrasonic power to rupture to microbubbles.
    Type: Application
    Filed: October 22, 2001
    Publication date: October 17, 2002
    Inventors: Stanley R. Conston, Ronald Yamamoto, Thomas B. Ottoboni, E. Glenn Tickner
  • Intravesical drug delivery system
    Publication number: 20010019719
    Abstract: Bioerodible, sustained release preparations are provided for placement into the bladder through the urethra which provide sustained release of drugs. Configurations are provided which are insertable through a catheter, such as a coiled filament, patch or a flowable gel. The device is bioeroded during or after the sustained release of the drug such that there is no blockage of the urinary tract while the device is in place within the bladder.
    Type: Application
    Filed: March 27, 2001
    Publication date: September 6, 2001
    Applicant: Point Biomedical Corporation
    Inventors: Thomas B. Ottoboni, Ronald K. Yamamoto, Stanley R. Conston
  • Microparticles useful as ultrasonic contrast agents and for delivery of drugs into the bloodstream
    Publication number: 20010012522
    Abstract: Microparticles are provided comprising a shell of an outer layer of a biologically compatible material and an inner layer of biodegradable polymer. The core of the microparticles contain a gas, liquid or solid for use in drug delivery or as a contrast agent for ultrasonic contrast imaging. The microparticles are capable of passing through the capillary systems of a subject.
    Type: Application
    Filed: January 11, 2001
    Publication date: August 9, 2001
    Inventors: Thomas B. Ottoboni, Robert E. Short, Ronald K. Yamamoto
  • Intravesical drug delivery
    Patent number: 6207180
    Abstract: Bioerodible, sustained release preparations are provided for placement into the bladder through the urethra which provide sustained release of drugs. Configurations are provided which are insertable through a catheter, such as a coiled filament, patch or a flowable gel. The device is bioeroded during or after the sustained release of the drug such that there is no blockage of the urinary tract while the device is in place within the bladder.
    Type: Grant
    Filed: March 14, 2000
    Date of Patent: March 27, 2001
    Inventors: Thomas B. Ottoboni, Ronald K. Yamamoto, Stanley R. Conston
  • Microparticles useful as ultrasonic contrast agents
    Patent number: 6193951
    Abstract: Microparticles are provided comprising a shell of an outer layer of a biologically compatible material and an inner layer of biodegradable polymer. The core of the microparticles contain a gas, liquid or solid for use in drug delivery or as a contrast agent for ultrasonic contrast imaging. The microparticles are capable of passing through the capillary systems of a subject.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: February 27, 2001
    Assignee: Point Biomedical Corporation
    Inventors: Thomas B. Ottoboni, Robert E. Short, Ronald K. Yamamoto
  • Intravesical drug delivery system
    Patent number: 6039967
    Abstract: Bioerodible, sustained release preparations are provided for placement into the bladder through the urethra which provide sustained release of drugs. Configurations are provided which are insertable through a catheter, such as a coiled filament, patch or a flowable gel. The device is bioeroded during or after the sustained release of the drug such that there is no blockage of the urinary tract while the device is in place within the bladder.
    Type: Grant
    Filed: April 2, 1998
    Date of Patent: March 21, 2000
    Assignee: Point Biomedical Corporation
    Inventors: Thomas B. Ottoboni, Ronald K. Yamamoto, Stanley R. Conston
  • Sustained release emulsions
    Patent number: 5977171
    Abstract: Ophthalmic methods and compositions are disclosed where particles of the dispersed phase of emulsions are themselves dispersed and stably maintained in physical separation by lightly crosslinked, water swellable polymers present in an aqueous polymeric system formulated for administration to the eye in drop or ribbon form. Medicament is dissolved in that dispersed phase is delivered over a sustained release period.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: November 2, 1999
    Assignee: InSite Vision, Inc.
    Inventors: Lyle M. Bowman, Rajesh A. Patel, Thomas B. Ottoboni
  • Liquid peracid precursor colloidal dispersions: macroemulsions
    Patent number: 5977044
    Abstract: A stable liquid peracid precursor composition for delivering a bleaching and cleaning material is provided in which the liquid peracid precursor composition combines a dispersion medium which comprises a stabilizing effective amount of a liquid matrix and an emulsifier, and a dispersed phase that comprises a peracid precursor. The bleaching and cleaning material comprises either a hydrophobic or hydrotropic generated mono- or diperoxyacid, or mixtures thereof.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: November 2, 1999
    Inventors: David Peterson, James D. McManus, Thomas B. Ottoboni, Charles B. Ungermann, Gregory Van Buskirk, Boli Zhou
  • Ocular microsphere delivery system
    Patent number: 5837226
    Abstract: A sustained release drug delivery composition and a method of making same are provided which comprises microspheres containing a pharmaceutically active agent, a core of a ion-exchange resin and a polymeric coating completely surrounding the core wherein the coating is water-insoluble and hydrolytically stable in physiological environments. The coating is non-erodible in physiological environments and is characterized by a diffusion constant suitable for the pharmaceutical agent to diffuse from the core to an aqueous environment at a predetermined release rate.
    Type: Grant
    Filed: September 19, 1995
    Date of Patent: November 17, 1998
    Assignee: Vitaphore Corporation C/O Integra Lifesciences Corp.
    Inventors: Lisa B. Jungherr, Thomas B. Ottoboni
  • Liquid peracid precursor colloidal dispersions: macroemulsions
    Patent number: 5776877
    Abstract: A stable liquid peracid precursor composition for delivering a bleaching and cleaning material is provided in which the liquid peracid precursor composition combines a dispersion medium which comprises a stabilizing effective amount of a liquid matrix and an emulsifier, and a dispersed phase that comprises a peracid precursor. The bleaching and cleaning material comprises either a hydrophobic or hydrotropic generated mono- or diperoxyacid, or mixtures thereof.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: July 7, 1998
    Assignee: The Clorox Company
    Inventors: David Peterson, James D. McManus, Thomas B. Ottoboni, Charles B. Ungermann, Gregory van Buskirk, Boli Zhou