Abstract: This invention relates to a synthetic method for the preparation of Compound 1 and precursors thereof. Compound 1 is prepared via reaction of isoxazole 2 with phenylether (R)-3-ONa.

Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.

Abstract: In accordance with 37 C.F.R. § 1.125, a substitute specification has been included in lieu of substitute paragraphs in connection with the present Preliminary Amendment. The substitute specification is submitted in clean form, attached hereto, and is accompanied by a marked-up version showing the changes made to the original specification. The changes have been made in an effort to place the specification in better form for U.S. practice. No new matter has been added by these changes to the specification. Further, the substitute specification includes paragraph numbers to facilitate amendment practice as requested by the U.S. Patent and Trademark Office.

Abstract: An overcurrent protection device is for protecting a load arranged in a DC grid. The load is coupled to a supply busbar, which is connectable to a supply potential of the DC grid, in the DC grid via the overcurrent protection device. The overcurrent protection device is designed to ascertain a current trigger value based upon a detected value of a current flowing through the overcurrent protection device and a trigger characteristic which is assigned to the load and is based on the current; compare the current trigger value with a threshold, and either trigger the overcurrent protection device or not, based upon the result of the comparison. The current is taken into consideration together with a first or a second factor in the trigger characteristic based upon the current direction.

Abstract: A method and system are provided for vehicle stabilization of a hybrid vehicle in an event of brake slip of the drive wheels or an increased risk thereof. The method presupposes that the hybrid vehicle includes, between the internal combustion engine and the electric motor, a clutch by which the torque of the internal combustion engine can be decoupled from the drive wheels. With the clutch engaged, the resulting torque on the electric motor is produced by the torque of the internal combustion engine and the torque of the electric motor. The presence of a specific vehicle condition indicative of brake slip of the drive wheels or a risk thereof is recognized. If such a vehicle condition is recognized, the clutch between the internal combustion engine and the electric motor is released and the torque of the electric motor is increased.

Abstract: An internal milling cutter for producing a recess terminating in a radius in a workpiece, in particular for milling a crankshaft, comprises a tool holder having interchangeable cutting inserts detachably attached thereto. For the production of the radius, a plurality of first interchangeable cutting inserts are provided, which are arranged one after another in the direction of cut and have cutting edges which produce complementary portions of the radius, wherein the first interchangeable cutting inserts for producing the radius are identically configured.

Abstract: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.

Abstract: The invention relates to a method for precision machining of crankshafts or camshafts to final dimensional tolerances Rz<10 ?m, preferably ?5 ?m and concentricity tolerances ?30 ?m, preferably ?6 ?m, which have been machined and at least partially subjected to hardening, wherein after the first machining has been carried out and subsequent hardening to 45 to 60 HRC, preferably 50 to 53 HRC, a final machining is carried out by means of at least one milling tool, wherein it is provided that the final machining is carried out by means of cutting inserts made of coated hard metal. The invention further relates to a milling tool for precision machining of crankshafts or camshafts by carrying out the method of the invention.

Abstract: Systems and methods for automated laser microdissection are disclosed. In one variation, targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition to the location of an interior of a cut path. In another variation, a sample of biological material is mounted onto a polymer membrane which is then placed onto a substrate. Targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition with the targeted biological material on the side of the biological material. In yet another variation, a sample of biological material is mounted onto a polymer membrane which is then inverted onto a substrate. Targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition with the targeted biological material on the side of the polymer membrane.

Abstract: A system includes a first light source configured to emit light within a first wavelength light band, and a second light source configured to emit light within a second wavelength light band, where the first wavelength light band and the second wavelength light band are each reflected differently by biologic material (e.g., blood). The system also includes a light sensor configured to detect light within the first wavelength light band and the second wavelength light band and generate a first signal representative of received light intensity within the first wavelength light band and a second signal representative of received light intensity within the second wavelength light band. The system further includes circuitry configured to correlate the first signal and the second signal to determine whether at least one of the first signal or the second signal is associated with a periodic biologic function.

Abstract: A method and system are provided for vehicle stabilization of a hybrid vehicle in an event of brake slip of the drive wheels or an increased risk thereof. The method presupposes that the hybrid vehicle includes, between the internal combustion engine and the electric motor, a clutch by which the torque of the internal combustion engine can be decoupled from the drive wheels. With the clutch engaged, the resulting torque on the electric motor is produced by the torque of the internal combustion engine and the torque of the electric motor. The presence of a specific vehicle condition indicative of brake slip of the drive wheels or a risk thereof is recognized. If such a vehicle condition is recognized, the clutch between the internal combustion engine and the electric motor is released and the torque of the electric motor is increased.

Abstract: Compounds of a certain formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors.

Abstract: Compounds of formula (I) or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6, R7, m and n have the meanings as given in the description and the claims, which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.

Abstract: Systems and methods for automated laser microdissection are disclosed. In one variation, targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition to the location of an interior of a cut path. In another variation, a sample of biological material is mounted onto a polymer membrane which is then placed onto a substrate. Targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition with the targeted biological material on the side of the biological material. In yet another variation, a sample of biological material is mounted onto a polymer membrane which is then inverted onto a substrate. Targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition with the targeted biological material on the side of the polymer membrane.

Abstract: Compounds of a certain formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors.

Abstract: An internal milling cutter for producing a recess terminating in a radius in a workpiece, in particular for milling a crankshaft, comprises a tool holder having interchangeable cutting inserts detachably attached thereto. For the production of the radius, a plurality of first interchangeable cutting inserts are provided, which are arranged one after another in the direction of cut and have cutting edges which produce complementary portions of the radius, wherein the first interchangeable cutting inserts for producing the radius are identically configured.

Abstract: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.

Abstract: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.

Abstract: The invention relates to a method for precision machining of crankshafts or camshafts to final dimensional tolerances Rz<10 ?m, preferably ?5 ?m and concentricity tolerances ?30 ?m, preferably ?6 ?m, which have been machined and at least partially subjected to hardening, wherein after the first machining has been carried out and subsequent hardening to 45 to 60 HRC, preferably 50 to 53 HRC, a final machining is carried out by means of at least one milling tool, wherein it is provided that the final machining is carried out by means of cutting inserts made of coated hard metal. The invention further relates to a milling tool for precision machining of crankshafts or camshafts.

Abstract: The compounds of formula (I), wherein ring D and ring E together form a fused ring system selected from formula (II), (III), (IV), (V), (VI), (VII), and the salts of these compounds are novel, effective inhibitors of histone deacetylases.