Abstract: Generation and use of a focus quality metric that is intensity independent is described. In one example, the focus quality metric is generated by acquiring an image, such as an image of a patterned surface of a flow cell, and processing all or part (e.g., a sub-region or sub-image) to generate a Fourier transform of the respective image data. By way of example, in one embodiment a discrete Fourier transform may be applied to a sub-region of an image of a patterned flow cell surface. A focus quality metric that is intensity independent may be derived from the Fourier transform of the image data.

Abstract: In certain embodiments devices suitable for use as electro magnetic refreshable braille readers are disclosed. In some embodiments, the electromagnetic refreshable braille readers of the present disclosure include an actuation mechanism comprising a permanent magnet for latching and a coil adjacent to the magnet. In some embodiments the electromagnetic refreshable braille readers may comprise a separate enclosure comprising tactile elements that can be removably attached to the display so that the separate enclosure can be removed and cleaned by the user.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of Cbl-b, and the treatment of Cbl-b-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of Cbl-b, and the treatment of Cbl-b-mediated disorders.

Abstract: The invention provides compounds, compositions thereof, and methods of using the same for the inhibition of Cbl-b, and the treatment of a variety of Cbl-b-mediated diseases, disorders or conditions, associated with modulating the immune system implicating Cbl-b. Compounds are also useful for the study of Cbl-b enzymes in biological and pathological phenomena; the study of ubiquitination occurring in bodily tissues; and the comparative evaluation of new Cbl-b inhibitors or other regulators of cell cycle, DNA repair, differentiation, and innate and adaptive immunity in vitro or in vivo.

Abstract: The disclosure provides a structured illumination imaging system that utilizes an image sensor (e.g., an active pixel sensor) in an active plane of a patterned sample to increase image resolution. The imaged sample may be patterned and/or aligned over an image sensor such that each light sensor (e.g., pixel) of the image sensor has a respective plurality of features formed and/or mounted above it. In response to illumination, each of the features may emit fluorescent light that is collected by a pixel of the image sensor. During imaging, each pixel of the image sensor may be spatially multiplexed using structured illumination such that only a subset (e.g., one or two) of the features aligned over the pixel are illuminated with structured light during an image read.

Abstract: The present disclosure relates to tactile displays, for example electro-magnetic Braille displays. In certain disclosed embodiments, tactile displays may comprise capture plate assemblies. Such capture plate assemblies may be removable from tactile displays to facilitate cleaning and/or maintenance of the tactile display.

Abstract: The present disclosure relates to tactile displays, for example electro-magnetic Braille displays. In certain disclosed embodiments, tactile displays may comprise capture plate assemblies. Such capture plate assemblies may be removable from tactile displays to facilitate cleaning and/or maintenance of the tactile display.

Abstract: The present disclosure relates to tactile displays, for example electro-magnetic Braille displays. In certain disclosed embodiments, tactile displays may comprise capture plate assemblies. Such capture plate assemblies may be removable from tactile displays to facilitate cleaning and/or maintenance of the tactile display.

Abstract: Generation and use of a focus quality metric that is intensity independent is described. In one example, the focus quality metric is generated by acquiring an image, such as an image of a patterned surface of a flow cell, and processing all or part (e.g., a sub-region or sub-image) to generate a Fourier transform of the respective image data. By way of example, in one embodiment a discrete Fourier transform may be applied to a sub-region of an image of a patterned flow cell surface. A focus quality metric that is intensity independent may be derived from the Fourier transform of the image data.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of Cbl-b, and the treatment of Cbl-b-mediated disorders.

Abstract: An adapter for a tactile display is disclosed. The adapter can be used with a tactile display, such as a display that presents braille characters, to change or modify what is presented to a user. In some embodiments, the braille dots which make up a braille character can be made smaller or larger; spaced closer together or further apart; have a different shape; and/or an image or non-braille characters can be presented to a user of the tactile display using the disclosed adapter.

Abstract: In certain embodiments devices suitable for use as electro magnetic refreshable braille readers are disclosed. In some embodiments, the electromagnetic refreshable braille readers of the present disclosure include an actuation mechanism comprising a permanent magnet for latching and a coil adjacent to the magnet. In some embodiments the electromagnetic refreshable braille readers may comprise a separate enclosure comprising tactile elements that can be removably attached to the display so that the separate enclosure can be removed and cleaned by the user.

Abstract: A gaming machine includes a cabinet at least partially defining a cavity opening and an internal cavity at least partially visible through the cavity opening, a primary display, a secondary display positioned within the internal cavity and visible through the cavity opening, a display movement assembly coupled to the primary display, and logic circuitry. The display movement assembly selectively moves the primary display between an open position and a closed position in which the primary display blocks visibility through the cavity opening. The logic circuitry causes the primary display in the closed position to present a first portion of a game, causes the display movement assembly to move the primary display to the open position to expose the cavity opening and the secondary display, and, in response to the secondary display being exposed, causes the secondary display to present a second portion of the game.

Abstract: An adapter for a tactile display is disclosed. The adapter can be used with a tactile display, such as a display that presents braille characters, to change or modify what is presented to a user. In some embodiments, the braille dots which make up a braille character can be made smaller or larger; spaced closer together or further apart; have a different shape; and/or an image or non-braille characters can be presented to a user of the tactile display using the disclosed adapter.

Abstract: The present disclosure relates to tactile displays, for example electro-magnetic Braille displays. In certain disclosed embodiments, tactile displays may comprise capture plate assemblies. Such capture plate assemblies may be removable from tactile displays to facilitate cleaning and/or maintenance of the tactile display.

Abstract: An adapter for a tactile display is disclosed. The adapter can be used with a tactile display, such as a display that presents braille characters, to change or modify what is presented to a user. In some embodiments, the braille dots which make up a braille character can be made smaller or larger; spaced closer together or further apart; have a different shape; and/or an image or non-braille characters can be presented to a user of the tactile display using the disclosed adapter.

Abstract: In some aspects, the disclosure is directed to methods and systems for in-packet transmission power control. Measurement circuitry in communication with a transmission stage of a device is configured to generate a transmitted signal strength measurement signal based on an output of the transmission power amplifier during transmission of a packet. Measurement conversion circuitry connected to the measurement circuitry is configured to convert the transmitted signal strength measurement signal from the measurement circuitry to an output power measurement. Power control circuitry connected to the measurement conversion circuitry is configured to generate a power correction signal based on the output power measurement and an output power target value. Power ramping circuitry connected to the power control circuitry is configured to provide a gain signal to the transmission stage of the device based on the power correction signal.

Abstract: A container configured for storing a chainsaw chain and method for storing a chainsaw chain. The method requires a chainsaw chain and a container. The container has chamber configured to secure the width of a chainsaw chain. The container may have variable height and length but the width of the chamber in the container must be approximately that of the width of the chainsaw chain. The chainsaw chain is loaded into the storage container vertically so that the width of the chain securely fits into the width of the chamber. The length of the chain folds or bunches onto itself so as to planarly stack in the storage container. This container and method is intended to prevent tangling of the chainsaw chain and allows for efficient storage of the chainsaw chain.

Abstract: In some aspects, the disclosure is directed to methods and systems for in-packet transmission power control. Measurement circuitry in communication with a transmission stage of a device is configured to generate a transmitted signal strength measurement signal based on an output of the transmission power amplifier during transmission of a packet. Measurement conversion circuitry connected to the measurement circuitry is configured to convert the transmitted signal strength measurement signal from the measurement circuitry to an output power measurement. Power control circuitry connected to the measurement conversion circuitry is configured to generate a power correction signal based on the output power measurement and an output power target value. Power ramping circuitry connected to the power control circuitry is configured to provide a gain signal to the transmission stage of the device based on the power correction signal.