Abstract: An overcurrent protection device is for protecting a load arranged in a DC grid. The load is coupled to a supply busbar, which is connectable to a supply potential of the DC grid, in the DC grid via the overcurrent protection device. The overcurrent protection device is designed to ascertain a current trigger value based upon a detected value of a current flowing through the overcurrent protection device and a trigger characteristic which is assigned to the load and is based on the current; compare the current trigger value with a threshold, and either trigger the overcurrent protection device or not, based upon the result of the comparison. The current is taken into consideration together with a first or a second factor in the trigger characteristic based upon the current direction.

Abstract: An overcurrent protection device is for protecting a load arranged in a DC grid. The load is coupled to a supply busbar, which is connectable to a supply potential of the DC grid, in the DC grid via the overcurrent protection device. The overcurrent protection device is designed to ascertain a current trigger value based upon a detected value of a current flowing through the overcurrent protection device and a trigger characteristic which is assigned to the load and is based on the current; compare the current trigger value with a threshold, and either trigger the overcurrent protection device or not, based upon the result of the comparison. The current is taken into consideration together with a first or a second factor in the trigger characteristic based upon the current direction.

Abstract: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.

Abstract: Compounds of formula (I) or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6, R7, m and n have the meanings as given in the description and the claims, which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.

Abstract: Compounds of a certain formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors.

Abstract: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.

Abstract: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.

Abstract: Compounds of a certain formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings indicated in the description, are effective compounds with anti-proliferative and/or apoptosis inducing activity.

Abstract: The invention relates to a cutting insert having an essentially parallelepiped-shaped basic body with two larger spaced-apart longitudinal surfaces (10,11) which are connected to one another by two smaller transverse surfaces (12, 13) and two smaller longitudinal surfaces (14) designed as rake faces, wherein the smaller longitudinal surfaces (14) form with the adjacent surfaces a respective, encircling, closed cutting line which forms the cutting edges and rounded-off cutting corners, and the larger longitudinal surface (10, 11) merges on both sides via respective rounded-off edges into the smaller transverse surface (12, 13), and one of the rounded-off cutting corners is designed so as to project relative to a basic shape which is determined by the cutting lines, on both sides, of the larger longitudinal surfaces (10, 11) with the smaller longitudinal surfaces (14).

Abstract: Compounds of a certain formula I, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors.

Abstract: Compounds of a certain formula I, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors.

Abstract: The present invention relates to a bifunctional compound of formula I or its pharmaceutically acceptable salts or solvates A-L-B (I) wherein A is a histone deacetylase (HDAC) inhibitory moiety, L is a single bond or a linker group and B is a protein kinase inhibitory moiety. The bifunctional compound according to formula (I) is useful for the treatment of malignant and non-malignant neoplasia and diseases related to abnormal cell growth.

Abstract: The invention relates to compounds of formula I, wherein Ra is —C(O)OR1, in which R1 is 1-7C-alkyl, 3-7C-cycloalkyl, or 1-7C-alkyl substituted by one to four substituents independently selected from R2, Rb is -T-Q, in which T is 1-6C-alkylene or 3-7C-cycloalkylene, and either Q is optionally substituted by Rba and/or Rbb and/or Rbc, and is phenyl or naphthyl, or Q is optionally substituted by Rca and/or Rcb, and is Har, or Q is optionally substituted by Rda and/or Rdb, and is Het, or Q is optionally substituted by Rea and/or Reb, and is 3-7C-cycloalkyl, which are useful for the therapy of hyperproliferative diseases, in particular human cancer.

Abstract: Compounds of a certain formula I, in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

Abstract: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

Abstract: Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

Abstract: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

Abstract: Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

Abstract: Compounds of a certain formula I, in which Ra, Rb and Rc have the meanings indicated in the description, are effective compounds with anti-proliferative and/or apoptosis inducing activity.

Abstract: Compounds of a certain formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors.