Abstract: Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.

Abstract: A tainting engine can work in conjunction with a syntax attack detection template to identify when a threat actor attempts a malicious attack in a cloud application scenario. Non-intrusive instrumentation can be used to provide detection of an attempted attack regardless of whether the cloud application is vulnerable to such attacks. Detection of attempted attacks can be an important part of maintaining network security, even in cases where an application itself is not vulnerable to such attacks. Further details about the attempted attack can be assembled, and a variety of actions can be taken in response to detection.

Abstract: Code injection is a type of security vulnerability in which an attacker injects client-side scripts modifying the content being delivered. A sanitizer function may provide defense against such attacks by removing certain characters (e.g., characters causing state transitions in HTML). A string sanitizer may be modeled in order to determine its effectiveness by obtaining data flow information indicating string operations that used an input string or information derived therefrom, including a string sanitizer function. A deterministic finite automata representing string values of the output parameter may be generated based on a graph generated from the data flow information, where the automata accepts possible output string values of the sanitizer. It can be determined whether there is a non-empty intersection between the automata for the sanitizer output and an automata representing a security exploit, which would indicate that the sanitizer function is vulnerable to the exploit.

Abstract: Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.

Abstract: A tainting engine can work in conjunction with a syntax attack detection template to identify when a threat actor attempts a malicious attack in a cloud application scenario. Non-intrusive instrumentation can be used to provide detection of an attempted attack regardless of whether the cloud application is vulnerable to such attacks. Detection of attempted attacks can be an important part of maintaining network security, even in cases where an application itself is not vulnerable to such attacks. Further details about the attempted attack can be assembled, and a variety of actions can be taken in response to detection.

Abstract: Code injection is a type of security vulnerability in which an attacker injects client-side scripts modifying the content being delivered. A sanitizer function may provide defense against such attacks by removing certain characters (e.g., characters causing state transitions in HTML). A string sanitizer may be modeled in order to determine its effectiveness by obtaining data flow information indicating string operations that used an input string or information derived therefrom, including a string sanitizer function. A deterministic finite automata representing string values of the output parameter may be generated based on a graph generated from the data flow information, where the automata accepts possible output string values of the sanitizer. It can be determined whether there is a non-empty intersection between the automata for the sanitizer output and an automata representing a security exploit, which would indicate that the sanitizer function is vulnerable to the exploit.

Abstract: Embodiments relate to improving accuracy of security vulnerability detection by determining a context of a data flow from a target, generating an exploit, and injecting the exploit based upon the context to create a vulnerable Uniform Resource Locator (URL). The context may comprise a HTML context, a URL context, a JavaScript context, or a JSON context. Communication of the vulnerable URL to a testing platform results in validation of the presence of a security vulnerability. Embodiments may find particular value in detecting vulnerability to a client-side XSS attack, by generating a vulnerable URL containing an exploit that is injected based upon a collected taint flow. Where the target is a website, embodiments improve accuracy of client-side XSS validation exploits by identifying which characters of a URL enter a specific context (e.g., HTML or JavaScript), and replacing these characters with a payload designed to trigger code execution for validation.

Abstract: Various embodiments of systems and methods to track tainting information via non-intrusive bytecode instrumentation are described herein. The described techniques include, at one aspect, defining a taint-aware class to shadow an original data class. The taint-aware class includes a payload field to store objects of the original data class, a metadata field to store tainting information corresponding to the objects of the original data class, and a method proxying a corresponding method of the original data class. In another aspect, the instances of the original data class are replaced with corresponding instances of the taint-aware class in an application bytecode. Further, in a yet another aspect, when executing the application in a runtime environment, the method propagates the content of the metadata filed and calls the corresponding method of the original data class to manage the content of the payload field.

Abstract: Various embodiments of systems and methods to track tainting information via non-intrusive bytecode instrumentation are described herein. The described techniques include, at one aspect, defining a taint-aware class to shadow an original data class. The taint-aware class includes a payload field to store objects of the original data class, a metadata field to store tainting information corresponding to the objects of the original data class, and a method proxying a corresponding method of the original data class. In another aspect, the instances of the original data class are replaced with corresponding instances of the taint-aware class in an application bytecode. Further, in a yet another aspect, when executing the application in a runtime environment, the method propagates the content of the metadata filed and calls the corresponding method of the original data class to manage the content of the payload field.

Abstract: Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.

Abstract: Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.

Abstract: Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.

Abstract: A method for determining resistivity of subsurface formations includes generating an initial model of the formations from multiaxial electromagnetic transimpedance measurements, the model comprising values of vertical resistivity, horizontal resistivity, crossbed dip, crossbed azimuth, and bedding dip and azimuth. Expected measurements generated from the initial model measurements are decomposed into ordinary and extraordinary components. The actual tool measurements are compared to the summation of the expected decomposed measurement components. The initial model is adjusted, the expected decomposed components are recalculated and the foregoing are repeated until the difference between the actual tool measurements and the summation of the expected decomposed components falls below a selected threshold.

Abstract: Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.

Abstract: Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.

Abstract: The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present in a sample, e.g., maternal blood and rare cell components, e.g., fetal cell nuclei. The invention further provides a method for preferentially lysing cells of interest in a sample, e.g., to extract clinical information from a cellular component, e.g., a nucleus, of the cells of interest. In general, the method employs differential lysis between the cells of interest and other cells (e.g., other nucleated cells) in the sample.

Abstract: A method for determining resistivity of subsurface formations includes generating an initial model of the formations from multiaxial electromagnetic transimpedance measurements, the model comprising values of vertical resistivity, horizontal resistivity, crossbed dip, crossbed azimuth, and bedding dip and azimuth. Expected measurements generated from the initial model measurements are decomposed into ordinary and extraordinary components. The actual tool measurements are compared to the summation of the expected decomposed measurement components. The initial model is adjusted, the expected decomposed components are recalculated and the foregoing are repeated until the difference between the actual tool measurements and the summation of the expected decomposed components falls below a selected threshold.

Abstract: A cover for a food holder includes a body having an inner surface and an outer surface, the body having at least one aperture provided therein, the at least one aperture providing communication between the inner surface and the outer surface; and a serving implement having a first portion extending through the aperture along one of the inner and outer surfaces, and a second portion extending along the other of the inner and outer surfaces.

Abstract: Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.

Abstract: Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalogue the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene “mountains” and a much larger number of gene “hills” that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy.