Patents by Inventor Thomas Bare

Thomas Bare has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 1,2,5,10-tetrahydropyridazino [4,5-b]quinoline-1,10-dione compounds and methods for the treatment of pain
    Publication number: 20050227977
    Abstract: Compounds useful for the treatment of pain in accord with structural diagram I, or tautomers or pharmaceutically-acceptable salts of such compounds, wherein A, D and R1 are as disclosed in the specification. Also disclosed are methods for the treatment of pain using compounds according to structural diagram I and pharmaceutical compositions comprising compounds according to structural diagram I.
    Type: Application
    Filed: June 3, 2005
    Publication date: October 13, 2005
    Applicant: AstraZeneca AB
    Inventors: Dean Brown, Wenhua Xiao, Rebecca Urbanek, Megan Murphy, Thomas Bare
  • 1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-diones and their use for the treatment of pain
    Patent number: 6946463
    Abstract: Compounds according to structural diagram (I) are disclosed, wherein R1, A, E and D are as defined in the specification. Also disclosed are pharmaceutical compositions comprising a pain-ameliorating effective amount of a compound in accord with structural diagram (I). The following is an examiner's statement of reasons for allowance: In view of applicants' amendments to the claims which limit “E” to phenyl or cycloalkyl groups the rejections of the previous action no longer pertain as they at best teach “E” as alkyl.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: September 20, 2005
    Assignee: Astrazeneca AB
    Inventors: Dean Gordon Brown, Rebecca Ann Urbanek, Megan Murphy, Wenhua Xiao, Frances Marie McLaren, Edward Vacek, Thomas Bare, Carey Lynn Horchler, Christine Barlaam, Gary Banks Steelman
  • 7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione and the use thereof for the treatment of pain
    Patent number: 6933297
    Abstract: A compound, 7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione, its (?) enantiomer, its (+) enantiomer, pharmaceutically-acceptable salts thereof, a method for treating pain comprising administering a pain-ameliorating effective amount of the (?) enantiomer to an individual suffering from pain and pharmaceutical compositions containing the (?) enantiomer are disclosed.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: August 23, 2005
    Assignee: AstraZeneca AB
    Inventors: Dean Gordon Brown, Rebecca Ann Urbanek, Megan Murphy, Wenhua Xiao, Frances Marie McLaren, Edward Vacek, Thomas Bare, Carey Lynn Horchler, Christine Barlaam, Gary Banks Steelman, Vernon Alford
  • Compounds and methods for the treatment of pain
    Publication number: 20050124622
    Abstract: 2-substituted 7-chloro-4-hydroxy-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione compounds, pharmaceutical compositions and methods for the treatment of pain are disclosed.
    Type: Application
    Filed: December 19, 2000
    Publication date: June 9, 2005
    Inventors: Dean Brown, Rebecca Urbanek, Wenhua Xiao, Thomas Bare, Megan Murphy
  • Compound and method for the treatment of pain
    Publication number: 20050101603
    Abstract: A compound, 7-chloro-4-hydroxy-2-(2-chloro-4-methylphenyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione, pharmaceutically-acceptable salts thereof, a method for treating pain comprising administration of a pain-ameliorating effective amount of the compound and pharmaceutical compositions containing the compound.
    Type: Application
    Filed: September 3, 2004
    Publication date: May 12, 2005
    Inventors: Thomas Bare, Dean Brown, Megan Murphy, Rebecca Urbanek, Wenhua Xiao
  • 1,2,5,10-tetrahydropyridazino{4,5-b}quinoline-1,10-diones and their use for the treatment of pain
    Publication number: 20050070544
    Abstract: Compounds are disclosed according to structural diagram (1), wherein R1, A, D and E are as defined in the specification. Also disclosed are methods for the treatment of pain and pharmaceutical compositions comprising a pain-ameliorating effective amount of a compound in accord with structural diagram (1).
    Type: Application
    Filed: September 28, 2001
    Publication date: March 31, 2005
    Inventors: Megan Murphy, Wenhua Xiao, Dean Brown, Rebecca Urbanek, Frances MClaren, Edward Vacek, Thomas Bare, Carey Horchler, Christine Barlaam, Gary Steelman, Vernon Alford
  • 1, 2, 5, 10-tetrahydropyridazino[4, 5-b]quinoline-1,10-diones and their use for the treatment of pain
    Patent number: 6833368
    Abstract: Compounds useful for the treatment of pain in accord with structural diagram (I), or tautomers or pharmaceutically-acceptable salts of such compounds, wherein R1 and A are as disclosed in the specification. Also disclosed are methods for the treatment of pain using compounds according to structural diagram (I) and pharmaceutical compositions comprising compounds according to structural diagram (I).
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: December 21, 2004
    Assignee: AstraZeneca AB
    Inventors: Megan Murphy, Wenhua Xiao, Dean Gordon Brown, Rebecca Ann Urbanek, Frances Marie McLaren, Edward Vacek, Thomas Bare, Carey Lynn Horchler, Christine Barlaam, Gary Banks Steelman, Vernon Alford
  • 1, 2, 5, 10-tetrahydropyridazino[4, 5-b]quinoline-1,10-diones and their use for the treatment of pain
    Publication number: 20040058927
    Abstract: Compounds useful for the treatment of pain in accord with structural diagram (I), or tautomers or pharmaceutically-acceptable salts of such compounds, wherein R1 and A are as disclosed in the specification. Also disclosed are methods for the treatment of pain using compounds according to structural diagram (I) and pharmaceutical compositions comprising compounds according to structural diagram (I).
    Type: Application
    Filed: October 9, 2003
    Publication date: March 25, 2004
    Inventors: Megan Murphy, Wenhua Xiao, Dean Gordon Brown, Rebecca Ann Urbanek, Frances Marie McLaren, Edward Vacek, Thomas Bare, Carey Lynn Horchler, Christine Barlaam, Gary Banks Steelman, Vernon Alford
  • 1, 2, 5, 10-tetrahydropyridazino[4,5-b]quinoline-1,10-diones and their use for the treatment of pain
    Publication number: 20040053929
    Abstract: Compounds according to structural diagram (I) are disclosed, wherein R1, A, E and D are as defined in the specification. Also disclosed are pharmaceutical compositions comprising a pain-ameliorating effective amount of a compound in accord with structural diagram (I).
    Type: Application
    Filed: September 8, 2003
    Publication date: March 18, 2004
    Inventors: Dean Gordon Brown, Rebecca Ann Urbanek, Megan Murphy, Wenhua Xiao, Frances Marie Mclaren, Edward Vacek, Thomas Bare, Carey Lynn Horchler, Christine Barlaam, Gary Banks Steelman
  • 7-Chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione and the use thereof for the treatment of pain
    Publication number: 20040053930
    Abstract: A compound, 7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b] quinoline-1,10-dione, its (−) enantiomer, its (+) enantiomer, pharmaceutically-acceptable salts thereof, a method for treating pain comprising administering a pain-ameliorating effective amount of the (−) enantiomer to an individual suffering from pain and pharmaceutical compositions containing the (−) enantiomer are disclosed.
    Type: Application
    Filed: September 8, 2003
    Publication date: March 18, 2004
    Inventors: Dean Gordon Brown, Rebecca Ann Urbanek, Megan Murphy, Wenhua Xiao, Frances Marie Mclaren, Edward Vacek, Thomas Bare, Carey Lynn Horchler, Christine Barlaam, Gary Banks Steelman, Vernon Alford